This JAMA article provides comprehensive guidance for clinicians on integrating diet and physical activity when prescribing GLP-1 receptor agonists for weight management. It outlines strategies for monitoring and managing both insufficient and excessive weight loss, emphasizing individualized approaches. The text details nutritional assessment and management, including specific dietary recommendations and a mnemonic for dietary guidance. Furthermore, it addresses the importance of physical activity, particularly resistance training, to preserve lean body mass and mitigate side effects. Finally, the article discusses weight loss maintenance and medication discontinuation, highlighting that obesity often requires long-term management similar to other chronic conditions.
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