Semaglutide (Ozempic and Wegovy)
Overview
Semaglutide is a medication used for the treatment of type 2 diabetes and, in some cases, for weight management in individuals with obesity. It belongs to a class of drugs known as GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists). Here are some key points about semaglutide:
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Mechanism of Action: Semaglutide works by mimicking the action of the hormone GLP-1, which is involved in blood sugar regulation. It helps increase insulin secretion, thereby lowering blood sugar levels, and decreases glucagon secretion. It also slows gastric emptying, which contributes to its effect on appetite and weight loss.
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Administration: It is typically administered via subcutaneous injection. There are different formulations available, including those for once-weekly injection. It’s important for patients to follow the specific dosing schedule prescribed by their healthcare provider.
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Use in Diabetes Treatment: Semaglutide is primarily used to improve blood sugar control in adults with type 2 diabetes. It is often prescribed in combination with diet and exercise, and sometimes in conjunction with other diabetes medications.
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Use in Weight Management: Semaglutide has also been shown to be effective in promoting weight loss in individuals with obesity or overweight, partly due to its appetite-suppressing effects. It is used under specific clinical conditions for weight management.
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Side Effects: Common side effects of semaglutide can include nausea, vomiting, diarrhea, abdominal pain, and constipation. These gastrointestinal symptoms are generally most prominent at the start of treatment and may diminish over time.
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Brand Names: Semaglutide is marketed under various brand names, including Ozempic® for diabetes treatment and Wegovy™ for weight management.
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Generic Availability: Semaglutide was under patent protection. Generic versions would typically become available after the expiration of the patent, allowing other companies to produce and sell cheaper versions.
How does Semaglutide work?
Semaglutide News
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The billion-dollar problem keeping Ozempic, Wegovy, and Zepbound from patientsby Latest Science News -- ScienceDaily on July 24, 2026
Ozempic, Wegovy, and similar drugs may deliver excellent health value, but covering them for […]
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Semaglutide sustains lower calorie intake for more than a year, study showsby Weight management on July 21, 2026
People taking semaglutide for weight loss continued to consume significantly fewer calories after […]
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US Clinical Trials involving semaglutide
| NCT Number | Study Title | Study URL | Study Status | Sponsor | Locations |
|---|---|---|---|---|---|
| NCT05756764 | Anti-obesity Pharmacotherapy and Inflammation | https://clinicaltrials.gov/study/NCT05756764 | RECRUITING | Louisiana State University Health Sciences Center in New Orleans | LSU Clinical & Translational Research Center (CTRC - - LSUHSC-NO, New Orleans, Louisiana, 70112, United States|Ochsner Health System - Bioespecimen, New Orleans, Louisiana, 70121, United States |
| NCT05646199 | Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | https://clinicaltrials.gov/study/NCT05646199 | NOT_YET_RECRUITING | University of Hull | Hull University Teaching Hospitals NHS Trust, Hull, HU32RW, United Kingdom |
| NCT05702905 | Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome | https://clinicaltrials.gov/study/NCT05702905 | RECRUITING | Peking University First Hospital | PekingUFH, Peking, Beijing, 100034, China |
| NCT05819853 | Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | https://clinicaltrials.gov/study/NCT05819853 | RECRUITING | University of Colorado, Denver | University of Colorado Anschutz/Children's Hospital Colorado Aurora, Aurora, Colorado, 80045, United States |