Cancer & Obesity Reviews (20 of the most recent)

• Maternal obesity and the intergenerational risk of cancer: Epidemiologic evidence and mechanistic insights April 16, 2026
  Over recent decades, the prevalence of obesity has markedly surged. While excess maternal weight is a well-established risk factor for adverse pregnancy outcomes, growing evidence suggests that maternal obesity may also increase the long-term risk of cancer in offspring. This comprehensive review synthesizes epidemiological and experimental data linking maternal obesity to heightened cancer susceptibility in […]
  Beat Moeckli
• The Impact of Obesity on Operative Outcomes and Long-Term Oncological Outcomes Following Rectal Cancer Surgery: A Retrospective Single-Center Study April 14, 2026
  Background: Our aim was to evaluate the impact of obesity on operative and long-term oncological outcomes following rectal cancer surgery. Methods: Single-center retrospective review of all patients that underwent rectal resection for primary rectal adenocarcinoma between 2010 and2020. Divided into two groups based on preoperative body mass index (BMI): obese-BMI ≥ 30 kg/m², non-obese-BMI < […]
  Dan Assaf
• Overweight and obesity increase breast cancer risk in postmenopausal women: a meta-analysis of 38 observational studies April 14, 2026
  Obesity is a recognized host-related factor associated with increased breast cancer (BC) risk-the most common malignancy and leading cause of cancer-related death among women. Menopausal status plays a critical role in this association due to hormonal and metabolic differences that may influence the impact of excess weight on carcinogenesis. This meta-analysis investigates the relationship between […]
  Piercarlo Del Console
• F2R and MXRA5: the metabolic obesity-derived biomarkers for immunosuppression and poor survival in triple-negative breast cancer April 12, 2026
  No abstract
  Xia Li
• Appetite, Obesity, Metabolism, and Malignancy: Do Incretin-Mimetic Drugs Reduce Cancer Risk? April 1, 2026
  Obesity is associated with increased risk of at least 13 adult cancer types and is the second most common cause of cancer (after tobacco) in many populations. Uncertainty about the extent to which intentional weight loss leads to reduced cancer risk represents a gap in knowledge. Evidence from bariatric surgery studies shows that sustained weight […]
  Andrew G Renehan
• Obesity and Tolerance to Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Cohort Study March 28, 2026
  CONCLUSIONS: Obesity is highly prevalent among high-risk early BC patients. It is independently associated with increased treatment-related toxicity, particularly discontinuation. These findings highlight the need for closer toxicity monitoring in patients with obesity. Reliance on BMI alone may be insufficient, underscoring the potential value of incorporating body composition assessment into clinical practice.
  Madalena Silveira Machado
• Obesity and Cancer: From Systemic Metabolic Reprogramming to Immunotherapy Paradox March 27, 2026
  With the global rise in overweight and obesity, excess adiposity has emerged as a modifiable carcinogenic exposure. Beyond energy surplus, obesity establishes a durable pro-tumorigenic baseline through endocrine-metabolic rewiring, chronic low-grade inflammation, and structural/mechanical remodeling of tissues, thereby shaping organ-specific microenvironments that favor malignant transformation and progression. This review integrates systemic metabolic and endocrine alterations […]
  Guoxiao Han
• Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology March 26, 2026
  The field of reverse cardio-oncology examines how subclinical and overt cardiometabolic dysfunction-such as obesity-fuels breast cancer (BCa) risk and altered tumour biology through shared mechanisms such as chronic inflammation, hormonal dysregulation, and cellular senescence. Limitations of body mass index (BMI) have prompted the development of refined obesity phenotypes, including metabolically healthy vs unhealthy obesity and […]
  Federico Carbone
• Targeting the gut microbiota as a treatment for obesity and cancer cachexia March 21, 2026
  INTRODUCTION: Obesity and cancer cachexia represent two seemingly contrasting yet interrelated ends of the metabolic disorder spectrum, both characterized by disrupted energy homeostasis, inflammation and neuroendocrine dysfunction, and associated with increased morbidity and mortality. Existing treatments often fail to address the complex underlying pathophysiological mechanisms. Emerging research highlights the role of the gut microbiome in […]
  Anna Giannakogeorgou
• Obesity-focused dietary interventions in breast cancer care: A comprehensive review of medical nutrition therapy approaches and efficacy in prevention and treatment March 20, 2026
  Obesity is associated with an increased risk of developing breast cancer, particularly in postmenopausal women, through mechanisms such as excessive estrogen production, insulin resistance, and chronic low-grade inflammation, all of which promote tumor initiation and progression. Alterations in the gut microbiota, frequently observed in obesity, further exacerbate this risk by influencing estrogen metabolism, modulating immune […]
  Claudia Reytor-González
• Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study March 11, 2026
  CONCLUSIONS: Chronic low-grade inflammation is a vital pathway linking genetically predicted BMI to breast cancer risk. Genetically predicted BMI is associated with higher genetically predicted CRP levels, potentially through a pathway involving reduced IGF-1 levels, which may attenuate the inverse association between genetically predicted BMI and breast cancer risk.
  Yu Hao
• Obesity and Cancer: A Translational Science Review March 9, 2026
  CONCLUSIONS AND RELEVANCE: Overweight and obesity are associated with higher rates of cancer and account for 10% of new cancer diagnoses annually in the US. Weight loss may reduce cancer risk by attenuating adverse effects of obesity, but greater than 10% weight loss may be necessary to reduce cancer risk.
  Sherry Shen
• Influence of obesity on breast cancer development in relation to menopausal status (Review) March 2, 2026
  Breast cancer (BC) ranks as the second most prevalent malignant tumor among women globally, posing a significant threat to female health. Obesity is recognized as an independent risk factor for both the development and progression of BC. Nevertheless, due to the complex mechanism through which obesity affects BC, coupled with the considerable variations in hormone […]
  Ziwen Yang
• Obesity, Bariatric Surgery, and Cancer Risk: Nutritional Perspectives and Long-Term Clinical Implications February 27, 2026
  Obesity is recognized as a causal risk factor for the development of multiple cancers, with risk magnitude varying by tumor site, sex, life stage, and adipose tissue distribution. This narrative review synthesizes recent epidemiological evidence linking excess body fatness with cancer incidence and mortality and integrates the biological mechanisms that explain this association. Chronic low-grade […]
  Claudia Reytor-González
• Obesity-linked genes may promote prostate cancer among Asian and Hispanic immigrants to North America February 25, 2026
  CONCLUSION: Obesity among immigrant populations provides a natural experiment that associates obesity with specific obesity-linked genes to suggest the mechanisms of increased prostate cancer.
  Dan Mercola
• Preventing obesity-related cancer with the revolution in obesity management: the challenges of undertaking a clinical trial and potential solutions February 24, 2026
  Evidence from conventional and Mendelian Randomisation epidemiological studies support the conclusion that obesity is causally associated with increased risk of several common cancer types. Some evidence, notably from quasi-experimental bariatric surgery studies, support the concept that sustained long-term weight loss in individuals is associated with reduction of cancer incidence, particularly in women. Yet, there are […]
  Matthew Harris
• The impact of obesity-related systemic inflammation on the efficacy, toxicity, and biomarkers of immune checkpoint inhibitors in lung cancer: from mechanisms to clinical management February 19, 2026
  Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of lung cancer, yet the heterogeneity in their efficacy and toxicity among different patients remains a significant clinical challenge. Obesity, as a global epidemic associated with chronic low-grade systemic inflammation and complex immunometabolic disturbances, has been identified as a crucial regulatory factor in cancer immunotherapy response. […]
  Yewei Cai
• Adverse childhood experiences, obesity, and endometrial cancer: A case series and scoping review February 16, 2026
  CONCLUSION: Patients with endometrial cancer, class 3 obesity, and ACEs in our study reported a high degree of abuse and medical comorbidities. ACEs appear to increase the risk of endometrial cancer via obesity and complicate patient care, but a formal association cannot be established.
  Haley D Frerichs
• Association Between GLP-1 Receptor Agonists and the Risk of Colon Cancer in Adults With Type 2 Diabetes or Obesity: A Systematic Review and Network Meta-Analysis February 11, 2026
  CONCLUSIONS: GLP-1 RAs may be associated with a lower risk of colon cancer in adults with type 2 diabetes mellitus, warranting further validation in trials among high-risk populations.
  Man Guo
• Obesity, survival, and chemotherapy outcomes in stage IV colorectal cancer: a retrospective study February 5, 2026
  CONCLUSIONS: Obesity at diagnosis is associated with improved OS in stage IV CRC. Patients with obesity underwent a longer duration of chemotherapy and experienced greater decreases in BMI during this period.
  Catherine G Tran