Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Celastrol at the obesity-cancer interface: critical appraisal of molecular mechanisms, preclinical evidence, and translational barriers July 17, 2026
Obesity is a modifiable risk factor for various malignancies and is mechanistically linked to hyperinsulinemia, insulin-like growth factor 1 (IGF-1) activation, adipokine imbalance, mitochondrial oxidative stress, and chronic low-grade inflammation. Tripterygium wilfordii-derived celastrol is a quinone-methide triterpenoid that possesses multiple activities targeting metabolic, inflammatory, and oncogenic signaling networks. The molecular evidence of celastrol at the […]
Asma B Omer
Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers July 13, 2026
Obesity is increasingly recognised as an important factor contributing to cancer progression, particularly in breast cancer. However, the cellular and molecular mechanisms underlying obesity-driven breast cancer remain unclear. Several theories have been proposed to explain the complex interactions between adipose tissue and cancer, incorporating both local and distant crosstalk. This review describes existing theories on […]
Charlise Basson
Review of Obesity and Cancer-Reply July 9, 2026
No abstract
Sherry Shen
Review of Obesity and Cancer July 9, 2026
No abstract
Zi-Li Huang
Role of GLP-1 receptor agonists in the prevention and treatment of obesity-related cancer July 7, 2026
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become pivotal in treating type 2 diabetes and obesity due to their ability to improve glycemic control and promote weight loss. Beyond their metabolic benefits, emerging evidence suggests that GLP-1 RAs may exert anticancer effects by modulating critical biological pathways involved in tumorigenesis, including insulin signaling, inflammation, and […]
Giovanna Muscogiuri
GLP-1 receptor agonists at immune checkpoint inhibitor initiation with immune-related and supportive-care outcomes in patients with cancer and overweight or obesity without diabetes: a target trial emulation July 4, 2026
CONCLUSIONS: GLP-1 RA add-on at ICI initiation was associated with fewer recorded wasting-related diagnoses and less acute-care use. The all-cause mortality reduction is exploratory, likely reflecting channeling bias rather than causation. These findings support prospective evaluation of GLP-1 RAs as supportive-care add-on therapy in ICI-treated patients with obesity.
Yu-Jung Lin
Obesity-driven extracellular vesicle signaling in cancer: mechanistic insights and clinical implications July 1, 2026
Obesity is a rapidly escalating global health challenge and a major, modifiable driver of cancer risk and poor outcomes across at least 13 malignancies, including endometrial, colorectal, breast, pancreatic, hepatic, renal, ovarian, and esophageal adenocarcinoma. Beyond endocrine and metabolic effects, obesity establishes a tumor-permissive systemic state characterized by adipose hypoxia, chronic inflammation, insulin resistance, and […]
Lakshmi Narasimhan Chakrapani
Leptin Signaling at the Crossroads of Obesity, Immunity, and Cancer: Mechanistic Insights and Therapeutic Implications June 30, 2026
Leptin, an adipokine predominantly secreted by adipose tissue, has exhibited a wide range of biological functions, including regulation of energy balance, appetite, and metabolism. Accumulating evidence has demonstrated that leptin also plays a role in obesity-associated tumor progression. Elevated circulating leptin levels in obese individuals, together with the close association between obesity and increased cancer […]
Gitima Deka
Microbiota-miR-101 interactions in obesity-associated colorectal cancer: from barrier dysfunction to precision therapeutic strategies June 29, 2026
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, with obesity recognized as a major modifiable risk factor. Obesity-associated CRC is characterized by systemic low-grade inflammation, altered lipid metabolism, and gut microbial dysbiosis, all of which converge to create a pro-inflammatory niche. Emerging evidence implicates murine miR-101a/b, an ortholog of the […]
Sidharth Prasad Mishra
Obesity-driven metabolic reprogramming and immune dysfunction in renal cancer June 29, 2026
Renal cell carcinoma (RCC), specifically clear cell renal cell carcinoma (ccRCC), is a metabolic tumor wherein the physiological state of the host is central to tumor development, progression, and therapeutic resistance. Obesity has emerged as one of the major risk factors associated with RCC; however, its impact on RCC is more complex than simply the […]
Henry N Ogbonna
From Leaky Gut to a Vulnerable Brain: Obesity-Associated Gut Barrier Failure in Colorectal Cancer and Cognitive Dysfunction June 26, 2026
Obesity is a major risk factor for colorectal cancer (CRC) and is increasingly recognized as a contributor to cancer-related cognitive impairment; however, the mechanistic pathways linking metabolic dysfunction, tumor progression, and brain dysfunction remain incompletely defined. Emerging evidence indicates that obesity-induced gut microbial dysbiosis and intestinal barrier disruption may serve as a biologically plausible mechanism […]
Soo Young Lee
Obesity-Driven Early-Onset Colorectal Cancer: Mechanistic Insights and Emerging Clinical Implications June 26, 2026
Early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before 50 years of age, has increased markedly over the past decades, especially in high-income settings. In parallel, obesity and related metabolic disturbances have become more common in both adults and younger populations, raising the possibility that excess adiposity contributes to the changing EOCRC burden. Epidemiological […]
Jian Liu
The Role of Angiogenesis in Breast Cancer and Obesity: Unravelling the Connection June 22, 2026
Breast cancer remains one of the leading causes of cancer-related mortality amongst women worldwide, with rising incidence rates paralleling the global obesity epidemic. Obesity has been increasingly recognised as a risk factor for breast cancer, yet the molecular mechanisms underlying the association remain poorly understood. This review explores the role of angiogenesis as the central […]
Yolo O K Sikuza
The Impact of Metabolic Bariatric Surgery on the Incidence of Breast Cancer in Patients with Obesity: A Systematic Review and Meta-Analysis June 15, 2026
CONCLUSION: Among women with obesity, metabolic bariatric surgery is associated with a substantially reduced risk of developing breast cancer. While these findings suggest a potential protective effect, further large- scale prospective studies are necessary to clarify causality and identify patients who may benefit most from surgical intervention.
Ragad Jalmood
Shaping breast cancer progression in obesity: Insights from advanced models and omics tools June 4, 2026
Obesity is a negative prognostic factor in BC, a heterogeneous and complex disease representing the leading cause of mortality from female cancer. Within the breast tumour microenvironment (TME), adipocytes, fibroblasts, immune cells and the extracellular matrix are aberrantly activated in obesity, leading to inflammatory responses, together with hormonal and metabolic changes, and activation of oncogenic […]
Rosalia Emma
The impact of visceral obesity on the outcomes after resection of colorectal cancer: a systematic review and meta-analysis June 3, 2026
Obesity is closely associated with the initiation and progression of colorectal cancer (CRC) and is widely recognized as a risk factor for unfavorable surgical outcomes. Nevertheless, the extent to which visceral obesity specifically influences perioperative safety and long-term oncologic outcomes following CRC resection remains to be established. We performed a systematic review and meta-analysis by […]
Shihao Wang
Understanding the Interplay Between Obesity and Cancer: From Mechanisms to Therapeutic Opportunities May 27, 2026
Obesity has risen to the forefront of global public health challenges, particularly due to its association with several chronic diseases. Its association with cancer has attracted significant research interest. The relationship between obesity and cancer is complex and profoundly influences tumorigenesis, cancer progression, metastasis, and therapeutic efficacy. This review provides the molecular basis of these […]
Sunsook Hwang
Multilevel insights into obesity, race/ethnicity, and survival in early-onset colorectal cancer in Georgia May 26, 2026
CONCLUSIONS: Findings suggest that mortality risk varies over time, with elevated risk in the first 1-3 years for White patients in high-obesity areas. Targeted efforts aimed at promoting healthy lifestyles and investing in community resources that foster healthier living may reduce early mortality.
Meng-Han Tsai
Targeting obesity and adipokine signaling in the breast cancer microenvironment for enhanced tumor therapy May 22, 2026
Breast cancer (BC) is a malignant breast tumor with high rates of metastasis and recurrence, making it the most common cancer in women and leading to a high mortality rate. Emerging evidence has indicated a close relationship between obesity and BC, as adipocytes, the largest cellular component of breast tissue, readily engage in crosstalk with […]
Wenhao Li
SAGES colorectal and metabolic bariatric surgery committee joint task force call to action for synchronized severe obesity and colorectal cancer management May 18, 2026
CONCLUSIONS: Severe obesity adversely influences CRC staging, operative complexity, and perioperative outcomes. Intentional metabolic optimization-through bariatric surgery or pharmacologic therapy-may represent a viable adjunct within multidisciplinary, patient-centered CRC care pathways. However, the absence of prospective short- and long-term outcome data underscores the need for systematic investigation to define optimal timing, safety parameters, and oncologic efficacy […]
Andreas M Kaiser

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma