February 2025

Study finds GLP-1 receptor agonists target fat over muscle for weight loss

Diabetes and obesity have become pressing health issues worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications widely used in the treatment of type 2 diabetes (T2D), have shown significant effectiveness in both lowering blood sugar levels and aiding weight loss due to their unique pharmacological mechanisms.

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Genetic evidence that diabetes drug GLP-1 receptor agonists achieve weight loss primarily by reducing fat mass more than muscle

Diabetes and obesity have become pressing health issues worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications widely used in the treatment of type 2 diabetes (T2D), have shown significant effectiveness in both lowering blood sugar levels and aiding weight loss due to their unique pharmacological mechanisms. A research team assessed the impact of GLP-1 receptor agonist in weight loss through genetic studies, aiming to understand whether the use of these medications reduces weight due to muscle or fat mass loss. This genetic study revealed that GLP-1 receptor agonists reduce weight by reducing more fat mass than muscle mass.

Genetic evidence that diabetes drug GLP-1 receptor agonists achieve weight loss primarily by reducing fat mass more than muscle Read More »

Cocaine user experiences reduced withdrawal cravings with GLP-1 therapy, case study reports

A doctor from the University of Palermo in Italy has published a case study of an adult cocaine user who experienced reduced withdrawal symptoms when given GLP-1 therapy. In the case study published in the Journal of Medical Case Reports, Doctor Vincenzo Maria Romeo reports on the treatment of an obese adult male patient with a history of cocaine abuse and how he responded to GLP-1 therapy.

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Many adults stop GLP-1 therapy within a year with low restart rates, analysis finds

A study conducted using electronic health record data from a collective of U.S. health care systems found that most adults with overweight or obesity discontinued glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy within one year. Discontinuation rates were significantly higher and reinitiation rates were significantly lower for patients without type 2 diabetes.

Many adults stop GLP-1 therapy within a year with low restart rates, analysis finds Read More »

What are the side effects of GLP-1 medications? A researcher explains

GLP-1 medications initially were used to help people with diabetes improve their insulin resistance and hunger cravings. However, over the past few years, these medications have become popular due to their weight loss and weight management benefits. Dr. Saundra Nguyen, assistant professor of internal medicine at Baylor College of Medicine, explains the side effects of GLP-1s.

What are the side effects of GLP-1 medications? A researcher explains Read More »

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