Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Moringa oleifera: an updated review of its composition and protective mechanisms in obesity, type 2 diabetes, and cancer September 1, 2026
Obesity, a significant risk factor for type 2 diabetes (T2D) and cancer, frequently co-occurs due to shared mechanistic pathways. Since 1990, global obesity prevalence has more than tripled, with projections indicating continued increases by 2050. In this context, Moringa oleifera (MO), known for its rich nutritional profile, shows considerable promise as a potential therapeutic intervention. […]
Palwasha Gul
Progress in Molecular Biological Mechanism of Endometrial Cancer Induced by Obesity August 27, 2026
Obesity is recognized as a major risk factor for endometrial cancer，and its tumor-promoting mechanisms have drawn increasing attention in recent years.Current evidence highlights that obesity drives the initiation and progression of endometrial cancer through three core pathways-elevated estrogen levels，insulin resistance，and chronic inflammation-which form a malignant positive feedback loop.Furthermore，visceral and subcutaneous obesity differentially regulate adipokine secretion […]
Ying Cao
The endocannabinoidome-microbiota axis in obesity: a potential link to colorectal cancer development August 21, 2026
Colorectal cancer (CRC) is a multifactorial disease strongly influenced by genetic and environmental factors, as well as by immune and metabolic disorders such as obesity and gut dysbiosis. Recent evidence highlights the interplay between the endocannabinoidome (eCBome) and the gut microbiota as a central regulatory axis of intestinal homeostasis, metabolism, and immune responses. Although no […]
Gabriela Ávila Alpino
Metabolic inflammation, obesity, and cancer August 20, 2026
Obesity is a global health concern, driving metabolic dysfunction and systemic inflammation. Here, we review the current understanding of the mechanisms underlying the impact of obesity in cancer susceptibility, progression, and response to therapy. We first discuss how resident and recruited macrophages adapt to metabolic stress within adipose tissue and the liver, which are metabolic […]
Fawaz Alzaid
Beyond weight: a stigma-free, integrated approach to obesity in patients affected by cancer August 18, 2026
CONCLUSIONS: A phase-sensitive, multidisciplinary, stigma-free framework moves obesity care away from a weight-centric paradigm and toward optimisation of body composition and metabolic health throughout the cancer trajectory.
Mikiko Watanabe
State-Level Prevalence of Obesity/overweight and Pancreatic Cancer Incidence in the United States: An Ecological Analysis Using BRFSS, CDC WONDER and ACS for the Year 2021 August 18, 2026
CONCLUSIONS: In this study, state-level O/OV prevalence failed to demonstrate a statistically significant association with PC incidence. Proportion of Black population was significantly associated with increased PC incidence. These findings suggest that population-level PC risk is likely influenced by multiple interacting metabolic, behavioral, sociodemographic, environmental, and healthcare-related factors beyond obesity alone. Further longitudinal and multivariable […]
Sanchit Mehta
Mammary Adipocyte Size, Obesity-Related Breast Adipose Tissue Dysfunction, and Breast Cancer: A Systematic Review and Meta-Analysis August 13, 2026
Background/Objectives: Mammary adipose tissue functions as an active endocrine organ, potentially influencing breast carcinogenesis through metabolic and inflammatory mechanisms. This systematic review synthesized evidence on associations between mammary adipocyte size, obesity-related adipose tissue dysfunction, and breast cancer. Methods: A comprehensive literature search was conducted across MEDLINE, EMBASE, CENTRAL, CINAHL and Web of Science (January 2010-September […]
Ouafa Badre
National Cancer Institute-Supported Obesity and Cancer Research, 2015-2022 August 12, 2026
CONCLUSIONS AND RELEVANCE: In this descriptive study of the FYs 2015 to 2022 obesity and cancer grants portfolio, results showed that the NCI has consistently supported study of this critical research area, establishing a strong evidence base. Understanding the complex intersection of obesity and cancer requires sustained, multidisciplinary research. Multiple opportunities exist for advancing the […]
Laura A Dwyer
Beyond Overdiagnosis: Evaluating the Drivers of Increasing Thyroid Cancer Incidence in the Era of Obesity, Environmental Exposure, and Advanced Diagnostics July 28, 2026
The global incidence of thyroid cancer (TC) has increased significantly in recent decades. Traditionally, this trend has been attributed to overdiagnosis resulting from the widespread use of imaging and improved diagnostic techniques, but increasing evidence suggests that current epidemiological patterns may not be fully explained by diagnostic factors alone. Most importantly, increasing rates of larger […]
Marta Druszcz
Holistic Management of Obesity in Patients with Incidental Cancer After Unprovoked Deep Vein Thrombosis: A Cardiometabolic and Antithrombotic Framework July 28, 2026
Background: Obesity has evolved from a morphometric descriptor to a chronic, relapsing, multisystem disease in which low-grade adipose-tissue inflammation, insulin resistance, endothelial dysfunction, and a prothrombotic, pro-tumorigenic milieu coexist. Venous thromboembolism (VTE) and malignancy share this substrate through a well-established bidirectional link: within twelve months of an unprovoked deep vein thrombosis (DVT), 6-15% of patients […]
Calogero Geraci
Concomitant Metabolic Bariatric Surgery and Minimally Invasive Hysterectomy for Endometrial Cancer or Endometrial Intraepitelhelial Neoplasia in Patients with Severe Obesity: A Systematic Review of Early Experience July 21, 2026
Severe obesity raises endometrial cancer (EC) risk and worsens outcomes. Combining metabolic bariatric surgery (MBS) with minimally invasive hysterectomy in a single encounter may streamline care. Following PRISMA 2020, we searched Scopus, Web of Science, and PubMed (final search January 2026) with a deliberately broad search strategy to identify all reports of concomitant MBS and […]
Murat Cengiz
Abdominal obesity and colorectal cancer risk: a systematic review and updated meta-analysis July 21, 2026
CONCLUSIONS: Central obesity is a significant and independent risk factor for colorectal cancer, with stronger associations observed for colon cancer than for rectal cancer and higher relative risks in men than in women. Visceral fat appears to play a critical role in colorectal carcinogenesis. Maintaining a healthy waist circumference through regular physical activity and a […]
Monireh Faghir-Ganji
Celastrol at the obesity-cancer interface: critical appraisal of molecular mechanisms, preclinical evidence, and translational barriers July 17, 2026
Obesity is a modifiable risk factor for various malignancies and is mechanistically linked to hyperinsulinemia, insulin-like growth factor 1 (IGF-1) activation, adipokine imbalance, mitochondrial oxidative stress, and chronic low-grade inflammation. Tripterygium wilfordii-derived celastrol is a quinone-methide triterpenoid that possesses multiple activities targeting metabolic, inflammatory, and oncogenic signaling networks. The molecular evidence of celastrol at the […]
Asma B Omer
Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers July 13, 2026
Obesity is increasingly recognised as an important factor contributing to cancer progression, particularly in breast cancer. However, the cellular and molecular mechanisms underlying obesity-driven breast cancer remain unclear. Several theories have been proposed to explain the complex interactions between adipose tissue and cancer, incorporating both local and distant crosstalk. This review describes existing theories on […]
Charlise Basson
Review of Obesity and Cancer-Reply July 9, 2026
No abstract
Sherry Shen
Review of Obesity and Cancer July 9, 2026
No abstract
Zi-Li Huang
Role of GLP-1 receptor agonists in the prevention and treatment of obesity-related cancer July 7, 2026
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become pivotal in treating type 2 diabetes and obesity due to their ability to improve glycemic control and promote weight loss. Beyond their metabolic benefits, emerging evidence suggests that GLP-1 RAs may exert anticancer effects by modulating critical biological pathways involved in tumorigenesis, including insulin signaling, inflammation, and […]
Giovanna Muscogiuri
GLP-1 receptor agonists at immune checkpoint inhibitor initiation with immune-related and supportive-care outcomes in patients with cancer and overweight or obesity without diabetes: a target trial emulation July 4, 2026
CONCLUSIONS: GLP-1 RA add-on at ICI initiation was associated with fewer recorded wasting-related diagnoses and less acute-care use. The all-cause mortality reduction is exploratory, likely reflecting channeling bias rather than causation. These findings support prospective evaluation of GLP-1 RAs as supportive-care add-on therapy in ICI-treated patients with obesity.
Yu-Jung Lin
Obesity-driven extracellular vesicle signaling in cancer: mechanistic insights and clinical implications July 1, 2026
Obesity is a rapidly escalating global health challenge and a major, modifiable driver of cancer risk and poor outcomes across at least 13 malignancies, including endometrial, colorectal, breast, pancreatic, hepatic, renal, ovarian, and esophageal adenocarcinoma. Beyond endocrine and metabolic effects, obesity establishes a tumor-permissive systemic state characterized by adipose hypoxia, chronic inflammation, insulin resistance, and […]
Lakshmi Narasimhan Chakrapani
Leptin Signaling at the Crossroads of Obesity, Immunity, and Cancer: Mechanistic Insights and Therapeutic Implications June 30, 2026
Leptin, an adipokine predominantly secreted by adipose tissue, has exhibited a wide range of biological functions, including regulation of energy balance, appetite, and metabolism. Accumulating evidence has demonstrated that leptin also plays a role in obesity-associated tumor progression. Elevated circulating leptin levels in obese individuals, together with the close association between obesity and increased cancer […]
Gitima Deka

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma