Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

A Review of the Relationship Between Obesity and Immunotherapy Response in Cancer October 16, 2026
Obesity is a growing public health concern, being correlated with several comorbidities including heart disease, liver disease, diabetes, and several cancers. It has been demonstrated that obesity increases the risk of developing several types of cancers as well as being associated with a worse prognosis, increased metastasis, increased recurrence, and worse response to therapy. Paradoxically, […]
Qiongyu Shi
Obesity and thyroid cancer: mechanisms and clinical implications October 14, 2026
The global rise in obesity has paralleled the increasing incidence of thyroid cancer, suggesting a potential pathophysiological link. This review comprehensively examines the epidemiological evidence linking obesity to thyroid cancer risk and progression, and elucidates the underlying biological mechanisms. Adipose tissue, particularly visceral fat, functions as an active endocrine organ secreting adipokines, cytokines, and hormones […]
Haiming Li
Obesity-associated inflammation and cancer: molecular mechanisms, evidence gaps, and therapeutic opportunities October 6, 2026
Obesity, recognized as a significant global public health issue, has garnered widespread attention. The chronic systemic inflammatory state characteristic of obesity may act as a key pathophysiological factor in the development of obesity-related cancers. Based on a structured literature search of peer-reviewed databases, this review summarizes the features of the inflammatory microenvironment within adipose tissue […]
Jiayi Meng
Metabolic Bariatric Surgery for Cancer Prevention and Risk Reduction in Patients with Obesity: A GRADE-Based International Federation for the Surgery and Other Therapies for Obesity (IFSO) Position Statement October 5, 2026
CONCLUSIONS: Current evidence suggests that MBS is associated with reduced incidence of several obesity related cancers. However, the certainty of the evidence is limited by residual selection bias, and heterogeneity.
Amanda Belluzzi
Crosstalk between visceral adipose tissue secretome and tumoral microenvironment in obesity-induced colorectal cancer October 1, 2026
CONCLUSIONS: In conclusion, the dysfunctional VAT secretome is the central architect in remodeling the CRC TME, thereby promoting the initiation, progression, and aggressiveness of this malignancy. This aspect is making the VAT secretome a vital target for future diagnostic and targeted therapeutic strategies for obese patients with CRC.
Diana-Iuliana Stanciu
Obesity, sleep apnea and cancer revisited October 1, 2026
Obstructive sleep apnea (OSA), obesity, and cancer constitute an interconnected pathophysiological triad withi mportant implications for morbidity and mortality. Obesity is a major upstream driver of both OSA and tumorigenesis, while OSA contributes independently through intermittent hypoxia, sleep fragmentation, systemici nflammation, oxidative stress, immune dysregulation, and sympathetic activation. Emerging evidence links OSA-associated hypoxemia to cancer […]
M Sánchez-de-la-Torre
Head and Neck Cancer Care in Patients with Obesity: Practical Considerations from Diagnosis to Adjuvant Therapy September 29, 2026
Obesity is increasingly common among patients evaluated for head and neck cancer and can complicate care even if it does not change core oncologic principles. This review follows the patient with obesity from initial referral through diagnostic evaluation, imaging, operative planning, wound management, and adjuvant therapy. Emphasis is placed on avoiding diagnostic anchoring, recognizing limitations […]
D Alexander Cronkite
Circulating microRNAs at the Interface of Obesity and Breast Cancer: From Molecular Machinery, Diagnostic Potential, and Therapeutic Perspectives September 26, 2026
Obesity influences breast cancer risk, progression, and therapeutic response through endocrine, inflammatory, metabolic, stromal, and vesicular mechanisms. Circulating and extracellular vesicle (EV)-associated microRNAs are attractive liquid biopsy candidates; however, in obesity-associated breast cancer, they should not be interpreted as tumor-only biomarkers. This narrative review analyzes circulating/EV-miRNAs as mixed host-tumor signals and separates association-based biomarker evidence […]
Georgina Victoria-Acosta
Robotic versus laparoscopic gastrectomy for gastric cancer in overweight patients, with obesity, or high visceral adiposity: a systematic review and meta-analysis of East Asian Cohorts September 25, 2026
High body mass index (BMI) and CT-defined visceral adiposity may increase the technical difficulty of minimally invasive gastrectomy for gastric cancer. Whether robotic gastrectomy offers a comparative advantage over laparoscopic gastrectomy in these adiposity-defined populations is uncertain. PubMed/MEDLINE, Scopus, and the Cochrane Library were searched from inception to 29 August 2026 using prespecified strategies; reference […]
Konstantinos Kossenas
Remodeling at the intersection of time and tissue: Aging, obesity, and the MT1-MMP proteolytic driver in ovarian cancer September 22, 2026
Ovarian cancer is the leading cause of gynecological cancer death for women in the United States. Aging and obesity are known risk factors that increase incidence rate, severity, and metastatic progression of ovarian cancer. With aging and obesity, physiological changes occur including increased inflammation, altered metabolism, and, most notably, extracellular matrix (ECM) remodeling. Remodeling of […]
Brighton C Strasiotto
Fueling early tumorigenesis: interplay between the exposome, obesity-driven metabolic dysfunction and early-onset colorectal and breast cancer September 15, 2026
Early-onset cancers (EOCs), defined as cancers diagnosed before the age of 50, are increasing globally. This rise cannot be fully explained by improved detection, suggesting the involvement of evolving environmental and lifestyle-related risk factors. In parallel, the global prevalence of obesity has increased substantially, particularly among younger populations. Obesity is increasingly recognized not simply as […]
Mansi Upadhyay
Obesity-related Metabolic Dysfunction and Triple-negative Breast Cancer: Epidemiologic Signals, Mechanistic Pathways, and Opportunities for Prevention September 11, 2026
PURPOSE OF REVIEW: Obesity is an established risk factor for postmenopausal hormone receptor-positive breast cancer, largely through estrogen-mediated pathways. Emerging evidence suggests that obesity-related metabolic dysfunction may also contribute to the risk and aggressive biology of receptor-negative breast cancer, particularly TNBC, among premenopausal women and populations undergoing rapid metabolic transition. This review evaluates epidemiologic, mechanistic, […]
Naser Elkum
Obesity-driven adipokine signaling in breast cancer: mechanistic insights, therapeutic challenges, and opportunities for precision oncology September 9, 2026
Breast cancer is the leading cause of illness and death among women worldwide, with more than 2.3 million new cases diagnosed each year. The incidence and fatality rates are steadily increasing, notably in Asian countries. Obesity has been established as a major and growing risk factor for breast cancer progression. The World Health Organization reports […]
Vadakke Kunnumma Soonu
Metabolic predictors of response to immunotherapy in locally advanced or metastatic esophageal cancer: unveiling the obesity paradox September 8, 2026
PD-1 inhibitor-based immunotherapy is increasingly used for locally advanced or metastatic esophageal cancer, yet the impact of metabolic factors-including the emerging "obesity paradox", wherein high-body mass index (BMI) patients demonstrate a lower risk of all-cause cancer mortality and superior immunotherapy efficacy compared to those with a low-to-normal BMI-on treatment efficacy remains largely unknown. Patients were […]
Jiaqi Tan
Low muscle mass, obesity, and cause-specific mortality in cancer patients: a nationwide cohort study September 5, 2026
CONCLUSIONS: LMM was independently associated with increased mortality in cancer patients, regardless of obesity status. The adverse effect was amplified in those with both LMM and obesity, but obesity alone showed a modest inverse association. These findings highlight the clinical relevance of evaluating muscle mass and body composition in cancer.
Dagyeong Lee
Physical exercise as an adjunctive therapy in obesity-associated cancer: From biological rationale to a pragmatic clinical framework September 4, 2026
Obesity represents a well-established risk factor for numerous cancers, contributing substantially to the global burden of this disease. In parallel, accumulating evidence supports the relevant biological effects of physical activity in counteracting the pathological mechanisms linking obesity to carcinogenesis and tumor progression, including chronic low-grade inflammation, adipocyte dysfunction, and insulin resistance, which collectively promote the […]
Giuseppe Annunziata
Moringa oleifera: an updated review of its composition and protective mechanisms in obesity, type 2 diabetes, and cancer September 1, 2026
Obesity, a significant risk factor for type 2 diabetes (T2D) and cancer, frequently co-occurs due to shared mechanistic pathways. Since 1990, global obesity prevalence has more than tripled, with projections indicating continued increases by 2050. In this context, Moringa oleifera (MO), known for its rich nutritional profile, shows considerable promise as a potential therapeutic intervention. […]
Palwasha Gul
Progress in Molecular Biological Mechanism of Endometrial Cancer Induced by Obesity August 27, 2026
Obesity is recognized as a major risk factor for endometrial cancer，and its tumor-promoting mechanisms have drawn increasing attention in recent years.Current evidence highlights that obesity drives the initiation and progression of endometrial cancer through three core pathways-elevated estrogen levels，insulin resistance，and chronic inflammation-which form a malignant positive feedback loop.Furthermore，visceral and subcutaneous obesity differentially regulate adipokine secretion […]
Ying Cao
The endocannabinoidome-microbiota axis in obesity: a potential link to colorectal cancer development August 21, 2026
Colorectal cancer (CRC) is a multifactorial disease strongly influenced by genetic and environmental factors, as well as by immune and metabolic disorders such as obesity and gut dysbiosis. Recent evidence highlights the interplay between the endocannabinoidome (eCBome) and the gut microbiota as a central regulatory axis of intestinal homeostasis, metabolism, and immune responses. Although no […]
Gabriela Ávila Alpino
Metabolic inflammation, obesity, and cancer August 20, 2026
Obesity is a global health concern, driving metabolic dysfunction and systemic inflammation. Here, we review the current understanding of the mechanisms underlying the impact of obesity in cancer susceptibility, progression, and response to therapy. We first discuss how resident and recruited macrophages adapt to metabolic stress within adipose tissue and the liver, which are metabolic […]
Fawaz Alzaid

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma