Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

The impact of obesity-related systemic inflammation on the efficacy, toxicity, and biomarkers of immune checkpoint inhibitors in lung cancer: from mechanisms to clinical management February 19, 2026
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of lung cancer, yet the heterogeneity in their efficacy and toxicity among different patients remains a significant clinical challenge. Obesity, as a global epidemic associated with chronic low-grade systemic inflammation and complex immunometabolic disturbances, has been identified as a crucial regulatory factor in cancer immunotherapy response. […]
Yewei Cai
Adverse childhood experiences, obesity, and endometrial cancer: A case series and scoping review February 16, 2026
CONCLUSION: Patients with endometrial cancer, class 3 obesity, and ACEs in our study reported a high degree of abuse and medical comorbidities. ACEs appear to increase the risk of endometrial cancer via obesity and complicate patient care, but a formal association cannot be established.
Haley D Frerichs
Association Between GLP-1 Receptor Agonists and the Risk of Colon Cancer in Adults With Type 2 Diabetes or Obesity: A Systematic Review and Network Meta-Analysis February 11, 2026
CONCLUSIONS: GLP-1 RAs may be associated with a lower risk of colon cancer in adults with type 2 diabetes mellitus, warranting further validation in trials among high-risk populations.
Man Guo
Obesity, survival, and chemotherapy outcomes in stage IV colorectal cancer: a retrospective study February 5, 2026
No abstract
Catherine G Tran
Association of low muscle mass and obesity with mortality and cardiovascular outcomes in breast cancer: a population-based study February 4, 2026
CONCLUSIONS: LMM was independently associated with increased mortality in breast cancer patients, with risk amplified in those with coexisting obesity.
Sohyun Chun
Intentional Preoperative Weight Loss for Obesity in Patients Undergoing Gastrointestinal Cancer Resections: A Systematic Review and Meta-analysis February 3, 2026
CONCLUSION: Intentional preoperative weight loss appears feasible, safe, and may improve postoperative outcomes in patients with obesity undergoing GI cancer surgery. Integration of such strategies, particularly during neoadjuvant therapy windows, offers a modifiable opportunity to optimise surgical risk. Prospective trials are warranted to define optimal protocols, timing, and oncologic safety.
Rathin Gosavi
Obesity and colorectal cancer risk: A systematic review and meta-analysis January 29, 2026
CONCLUSION: Obesity, diagnosed by a BMI ≥ 30 kg/m², significantly increases the risk of CRC incidence compared to those of a healthy BMI underscoring the importance of focused strategies to prevent obesity as a modifiable risk factor to reduce CRC incidence.
Lachlan James Chun-Lok Leung
Breast Cancer and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation and Obesity January 28, 2026
Cardiovascular diseases, malignancy, and diabetes mellitus are the most common chronic non-communicable diseases affecting the population in Serbia. According to The Cancer Registry of the Republic of Serbia, breast cancer is the most common cancer affecting women in Serbia. Every year, 4600 women get diagnosed with BC, and 1600 women die from this disease. Every […]
Barbara Loboda
Strategies to inhibit steroid cytochrome P450 enzymes to benefit human health: development of steroid ligands for P450s 17A1, 19A1, and 8B1 to treat cancer and obesity January 19, 2026
Several human cytochrome P450 enzymes (P450s) found in steroid/oxysterol biosynthesis are therapeutic targets to treat disease. This review article describes current research strategies to develop various inhibitors of three steroid P450s (P450s 17A1, 19A1, and 8B1) in order to benefit human health. (i) P450 17A1 (17α-hydroxylase/17,20-lyase) activity involves the hydroxylation at C17 and cleavage of […]
Tu M Ho
Understanding obesity-cancer crosstalk to inform the immunomodulatory roles of anti-obesity nanotherapeutics January 19, 2026
Obesity represents a chronic inflammatory condition characterized by adipose tissue dysfunction that drives systemic metabolic derangements and promotes tumor progression. Adipose inflammation, dominated by pro-inflammatory macrophages and dysregulated adipokine secretion, not only impairs lipid metabolism but also suppresses anti-tumor immunity. Although anti-obesity medications (AOMs) can induce weight loss, their limited ability to resolve inflammation constrains […]
Fang Zhou
Fueling Disease: ACSS2 in Obesity-Associated Metabolic Disorders and Cancer Progression January 16, 2026
Obesity is a major risk factor for metabolic disorders and cancer, largely due to dysregulated nutrient sensing and metabolic reprogramming. Acyl-CoA synthetase short-chain family member 2 (ACSS2) is a key enzyme that converts acetate into acetyl-CoA, fueling de novo lipogenesis and histone acetylation. In obesity, ACSS2 expression is transcriptionally induced by sterol regulatory element-binding proteins […]
Liuting Chen
Obesity and cancer: Relevance of DNA damage response January 16, 2026
Obesity is a non-communicable, multifactorial disorder that has steadily emerged as one of the major global health concerns. It significantly increases the risk of diabetes, cardiovascular diseases and cancer. In obesity, the accumulation of excess fat causes increase in the circulatory levels of adipose tissue-specific hormones (adipokines) and exacerbates carbohydrate-fuelled metabolic stress. These factors promote […]
Bhavana Deshmukh
Multidimensional risk impact of obesity on breast cancer incidence, treatment, and prognosis January 12, 2026
Breast cancer has now become the most common malignant tumor and the leading cause of cancer deaths in women worldwide, and its pathogenesis has not yet been elucidated. Obesity is a risk factor for multiple cancers, and with the improvement of living standards and changes in dietary structure, obesity has become a major public health […]
Yang Liu
Impact of overweight and obesity on gastric and colorectal cancer incidence in the older adults: a nationwide cohort study January 10, 2026
CONCLUSIONS: Overweight or obesity are modifiable risk factors for gastrointestinal cancers in the older adults. Maintaining a normal weight through appropriate weight control may have a beneficial effect on the prevention of gastrointestinal cancers in the older adults.
Jinju Choi
Metabolic Syndrome and Obesity-related cancer Risk and Survival: An Umbrella Review of Systematic Reviews With Meta-analysis of Observational Studies January 9, 2026
CONCLUSION: This umbrella review suggests metabolic syndrome increases the risk of several obesity-related cancers and worsens colorectal cancer survival. Despite study variability, consistent associations across diverse populations highlight the urgency of prevention and management strategies targeting metabolic dysfunction to reduce cancer burden. Summary In this umbrella review, highly suggestive and suggestive evidence supports associations between […]
Maci Winn
Distinct genetic profiles of obesity have different effects on breast cancer risk: leveraging Mendelian randomisation to interrogate causal pathways and identify mediating proteins January 9, 2026
CONCLUSIONS: These findings suggest that the effect of obesity on breast cancer is mediated through multiple distinct biological pathways. The identified proteins provide a first insight into the mechanisms underlying these pathways. With further investigation, these results could provide a basis for developing personalised treatment strategies.
Marina Isabel Marchal
The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer January 8, 2026
CONCLUSION: Future longitudinal studies are needed to clarify causal relationships, validate microbial biomarkers, and translate preclinical findings into clinical applications. Addressing the gut-breast axis may offer transformative potential for precision oncology in obesity-driven BC.
Huiyue Zhang
Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction January 8, 2026
Obesity promotes carcinogenesis through interlocking metabolic, inflammatory, immune, and hormonal pathways. We narratively synthesize recent meta-analyses and selected cohort studies that examine adiposity-principally body mass index (BMI) and waist circumference-in relation to cancer incidence. Across the 13 cancers designated by the U.S. National Cancer Institute as obesity-associated, risk elevations are generally consistent, though magnitudes vary […]
Jung-Sun Lim
Obesity is a major modifiable factor associated with ER-negative breast cancer: epidemiological and mechanistic evidence from a high-risk cohort December 30, 2025
CONCLUSIONS: Obesity is a major, modifiable factor strongly associated with TNBC, with its effect magnified in high-risk populations. The mechanistic link to ER and HER2 suppression suggests a plausible biological pathway, highlighting metabolic health as a critical target for prevention strategies worldwide.
Naser Elkum
Obesity as a Systems-Level Driver of Cancer: Mechanisms and Nutritional Reprogramming December 30, 2025
Obesity has emerged as a global health crisis and a potent driver of cancer incidence and mortality, yet its mechanistic impact on tumor biology remains underappreciated. Far from being a passive risk factor, obesity acts as a systems-level oncogenic stressor, reshaping hormonal signaling, immunometabolism, and epigenetic stability across the body. This review synthesizes current knowledge […]
Camelia Munteanu

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma