Colon & Rectum Cancer - Obesity Reviews, Recent Papers, and Clinical Trials
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To see all 79 Reviews, go directly to PubMed.
REVIEWS from PubMed – November 11, 2023 Obesity (in title) AND Colon or Rectum (in title) AND Cancer (in title) AND Review
- Outcomes of Metabolic and Bariatric Surgery in Populations with Obesity and Their Risk of Developing Colorectal Cancer: Where Do We Stand? An Umbrella Review on Behalf of TROGSS-The Robotic Global Surgical Society February 26, 2025Introduction: Obesity is a chronic disease associated with increased risk for several cancers, including colorectal cancer (CRC), a leading cause of cancer-related mortality. The majority of CRC cases are associated with modifiable risk factors. Metabolic and bariatric surgery (MBS) is a proven, durable, and successful intervention for obesity. This study aimed to evaluate the impact […]Aman Goyal
- Ultra-processed food, obesity, and colon cancer: A systematic review and meta-analysis February 17, 2025CONCLUSION: Consuming ultra-processed foods increases the risk of obesity and colon cancer.Justin Tin
- Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis January 11, 2025Sarcopenic obesity is a condition in which the coexistence of sarcopenia and obesity may have unfavorable prognostic implications in cancer. This meta-analysis aims to evaluate the effects of sarcopenic obesity on postoperative outcomes in patients undergoing colorectal cancer surgery. A systematic literature search was conducted in the Scopus, PubMed, and Web of Science databases for […]Tuba Nur Yıldız Kopuz
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity January 7, 2025Colorectal cancer (CRC) is the third most common cancer worldwide and has one of the highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation and development, with obesity at the forefront. Obesity is regarded as one of the key environmental risk determinants for the pathogenesis of CRC. Excessive food […]Mikołaj Domagalski
- Dietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation December 30, 2024Dietary fiber, found in plant-based foods, plays an essential role in human health. It is divided into two types-soluble and insoluble-both offering significant health benefits. Research has shown that increasing fiber intake can reduce the risk of various chronic diseases, such as cardiovascular diseases (CVD), type II diabetes, obesity, colon cancer, and inflammation. These health […]Layla A Alahmari
- Impact of obesity and diabetes on colorectal cancer in Saudi Arabia is associated with liver gamma-glutamyl transferase abnormality December 9, 2024Colorectal cancer (CRC) is a leading global cause of death. In Saudi Arabia, it is the most common cancer among men and the third most common among women. Obesity, diabetes and CRC have become significant health concerns. The present study aimed to explore the connection between liver function markers, obesity and diabetes in patients with […]Glowi Alasiri
- A Review Article: The Relationship Between Obesity and Colorectal Cancer December 2, 2024PURPOSE OF REVIEW: This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.Lily Nguyen
- Systematic review: The gut microbiota as a link between colorectal cancer and obesity November 30, 2024Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and […]Antonio Jesús Ruiz-Malagón
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk October 8, 2024The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to […]Zoltan Ungvari
- Advancements in Understanding and Preventing Obesity-Related Colon Cancer September 23, 2024Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and […]Christine Shieh
- Obesity-Associated Colorectal Cancer August 29, 2024Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through the secretion of proinflammatory cytokines. In addition to an increased inflammatory response, obesity-associated cancer presents accrued molecular factors related to cancer characteristics, such as […]Lucia Gonzalez-Gutierrez
- Obesity and Colorectal Cancer: A Narrative Review August 29, 2024Background and Objectives: Cancer is a multicausal disease, and environmental, cultural, socioeconomic, lifestyle, and genetic factors can influence the risk of developing cancer. Colorectal cancer (CRC) stands as the third most common cancer globally. Some countries have observed a rise in the incidence of CRC, especially among young people. This increase is associated with lifestyle […]Bárbara Cristina Jardim Miranda
- Obesity and overweight are associated with worse survival in early-onset colorectal cancer May 21, 2024CONCLUSION: Individuals with early-onset colorectal cancer who are overweight or obese present with similar tumor characteristics and postoperative morbidity to patients with normal weight. However, obesity may have a detrimental impact on their survival. Addressing obesity as a modifiable risk factor might improve early-onset colorectal cancer prognosis.Pauline Aeschbacher
- Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms May 20, 2024Early-onset colorectal cancer (EOCRC) is defined as diagnosed at younger than 50 years of age and indicates a health burden globally. Patients with EOCRC have distinct risk factors, clinical characteristics, and molecular pathogenesis compared with older patients with CRC. Further investigations have identified different roles of obesity between EOCRC and late-onset colorectal cancer (LOCRC). Most […]Peng Xu
- Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer April 13, 2024Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer through the production of metabolites such as itaconate. Itaconate downregulates peroxisome proliferator-activated receptor gamma as a tumor-suppressing factor and upregulates anti-inflammatory cytokines in M2-like macrophages. […]Alexandra N Jones
- Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer trial study protocol: a randomised clinical trial of fibre-rich legumes targeting the gut microbiome, metabolome and gut transit time of overweight and obese patients with a history of noncancerous adenomatous polyps February 5, 2024INTRODUCTION: Recently published studies support the beneficial effects of consuming fibre-rich legumes, such as cooked dry beans, to improve metabolic health and reduce cancer risk. In participants with overweight/obesity and a history of colorectal polyps, the Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer randomised clinical trial will test whether a high-fibre diet featuring […]Terryl J Hartman
- Correction: Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses January 16, 2024No abstractMarko Mandic
- Visceral obesity and anastomotic leakage rates in colorectal cancer: a systematic review and meta-analysis September 6, 2023CONCLUSIONS: Our findings confirmed the significant relationship between VO and AL. Thus, VO could be considered a reliable risk factor of surgery for colon cancer.Linchong Yu
- Obesity and Colorectal Cancer August 25, 2023The prevalence of obesity has increased significantly worldwide, and this trend is likely to continue in the coming years. There is substantial evidence that obesity plays a crucial role in the development of colorectal cancer. Epidemiological data have consistently demonstrated a correlation between obesity and colorectal cancer. Insulin resistance, hyperinsulinemia, chronic inflammation, altered levels of […]Jundeok Lee
- Diagnosis and prevalence of sarcopenic obesity in patients with colorectal cancer: A scoping review July 22, 2023CONCLUSIONS: SO in patients with CRC was mainly diagnosed based on a combination of SMI and BMI, and muscle strength and body composition were rarely evaluated. The prevalence of SO was approximately 15%, depending on the diagnostic methods used. Since SO in patients with CRC is associated with poor prognosis, further research on diagnostic methods […]Yoko Saino
To see all 358 Papers, Go directly to PubMed.
RECENT PAPERS from PubMed – November 11, 2023 Obesity (in title) AND Colon or Rectum (in title) AND Cancer (in title)
- Smilax glabra Flavonoids Inhibit AMPK Activation and Induce Ferroptosis in Obesity-Associated Colorectal Cancer March 27, 2025Smilax glabra flavonoids (SGF), the active components of Smilax glabra Roxb., have been demonstrated to exhibit antioxidant activity and metabolic benefits in obesity, leading us to further explore their antitumor effects in obesity-related colorectal cancer (CRC). This study investigated the antiproliferative effects of SGF on obesity-related CRC by using a murine colon adenocarcinoma MC38 cell […]Jianqin Xu
- The Role of Diet and the Gut Microbiota in the Obesity-Colorectal Cancer Link March 20, 2025Obesity is positively associated with colorectal cancer (CRC) risk. Diet not only contributes to obesity, but also strongly influences the gut microbiota, a factor that is thought to independently affect CRC. To isolate the role of obesity-associated gut microbiota in CRC and to assess the impact of diet composition on this relationship, we transplanted the […]Audrey A Goldbaum
- Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030 March 13, 2025BACKGROUND: Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of Colorectal cancer cases and deaths can be attributed to modifiable risk factors, with smoking, alcohol use, and high body mass index (BMI) being the three most prominent. However, the impact of these risk factors on Colorectal cancer […]Yuqi Deng
- Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? March 5, 2025Obesity (BMI > 30 kg/m²) is rapidly increasing worldwide with 26% of the UK population being obese and 38% being overweight. Obesity is intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patients have a higher degree of perioperative systemic inflammatory response (SIR) and an increased risk of perioperative complications. The aim of […]Abigail R Ingham
- Outcomes of Metabolic and Bariatric Surgery in Populations with Obesity and Their Risk of Developing Colorectal Cancer: Where Do We Stand? An Umbrella Review on Behalf of TROGSS-The Robotic Global Surgical Society February 26, 2025Introduction: Obesity is a chronic disease associated with increased risk for several cancers, including colorectal cancer (CRC), a leading cause of cancer-related mortality. The majority of CRC cases are associated with modifiable risk factors. Metabolic and bariatric surgery (MBS) is a proven, durable, and successful intervention for obesity. This study aimed to evaluate the impact […]Aman Goyal
- Predictive value of different obesity indicators for colorectal cancer in different sex populations February 19, 2025Objective: To investigate the predictive value of different obesity indicators for colorectal cancer (CRC) risk in different gender populations. Methods: This observational study was conducted within the Kailuan Study (Registration Number: ChiCTR-TNC-11001489). From July 2006 to October 2007, a total of 101,510 employed and retired individuals underwent health examinations, including gastrointestinal disease screening, hematological tests, […]C Ma
- Ultra-processed food, obesity, and colon cancer: A systematic review and meta-analysis February 17, 2025CONCLUSION: Consuming ultra-processed foods increases the risk of obesity and colon cancer.Justin Tin
- Sleep Duration, Dietary Inflammatory Potential, and Obesity in Relation to Colorectal Cancer Incidence in the Multiethnic Cohort February 13, 2025CONCLUSIONS: Long sleep duration and a combination of suboptimal sleep duration and a pro-inflammatory dietary pattern or obesity amplifies the risk.Penias Tembo
- Fat mass and obesity-associated protein expression in colorectal cancer and its influence on the biological behaviour of colorectal cancer cells January 24, 2025Fat mass and obesity-associated protein (FTO) was the earliest discovered m6A RNA demethylase. Previous studies have indicated that m6A modifications significantly influence the development, progression, and prognosis of various cancers. This study aimed to explore the role of FTO overexpression in colorectal cancer development, as well as its biological functions. Expression levels of FTO mRNA […]Huihui Wu
- Colorectal Cancer and Central Obesity January 17, 2025CONCLUSIONS AND RELEVANCE: In this cohort study of approximately half a million participants, the PAF of CRC attributable to excess weight, defined as high BMI, was considerably underestimated. The PAFs attributable to WC and WHR were consistent and much higher, underlining the importance of efforts to limit and overcome the obesity epidemic in CRC prevention.Fatemeh Safizadeh
- Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis January 11, 2025Sarcopenic obesity is a condition in which the coexistence of sarcopenia and obesity may have unfavorable prognostic implications in cancer. This meta-analysis aims to evaluate the effects of sarcopenic obesity on postoperative outcomes in patients undergoing colorectal cancer surgery. A systematic literature search was conducted in the Scopus, PubMed, and Web of Science databases for […]Tuba Nur Yıldız Kopuz
- To what extent is the association between obesity and colorectal cancer risk mediated by systemic inflammation? January 10, 2025No abstractFatemeh Safizadeh
- Exploring the role of Bisphenol A in obesity-driven colorectal cancer progression: network toxicology and multi-organ pathology in animal models January 9, 2025Bisphenol A (BPA), an endocrine disruptor, is linked to cancer progression in estrogen-responsive tissues, but its role in promoting colorectal cancer (CRC) progression in the context of obesity remains underexplored. This study examines BPA's influence on CRC in obese Sprague-Dawley rats using network toxicology and experimental models. Computational analysis using the Database for Annotation, Visualization, […]Muhamad Fikri Shazlan Saad
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity January 7, 2025Colorectal cancer (CRC) is the third most common cancer worldwide and has one of the highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation and development, with obesity at the forefront. Obesity is regarded as one of the key environmental risk determinants for the pathogenesis of CRC. Excessive food […]Mikołaj Domagalski
- Dietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation December 30, 2024Dietary fiber, found in plant-based foods, plays an essential role in human health. It is divided into two types-soluble and insoluble-both offering significant health benefits. Research has shown that increasing fiber intake can reduce the risk of various chronic diseases, such as cardiovascular diseases (CVD), type II diabetes, obesity, colon cancer, and inflammation. These health […]Layla A Alahmari
- Reply to letter to the editor on: "Potential prognostic factors of early-onset colorectal cancer in patients with obesity" December 17, 2024No abstractPauline Aeschbacher
- Impact of obesity and diabetes on colorectal cancer in Saudi Arabia is associated with liver gamma-glutamyl transferase abnormality December 9, 2024Colorectal cancer (CRC) is a leading global cause of death. In Saudi Arabia, it is the most common cancer among men and the third most common among women. Obesity, diabetes and CRC have become significant health concerns. The present study aimed to explore the connection between liver function markers, obesity and diabetes in patients with […]Glowi Alasiri
- Potential prognostic factors of early-onset colorectal cancer in patients with obesity December 4, 2024No abstractKota Tokunaga
- A Review Article: The Relationship Between Obesity and Colorectal Cancer December 2, 2024PURPOSE OF REVIEW: This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.Lily Nguyen
- Systematic review: The gut microbiota as a link between colorectal cancer and obesity November 30, 2024Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and […]Antonio Jesús Ruiz-Malagón