Colon & Rectum Cancer - Obesity Reviews, Recent Papers, and Clinical Trials
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To see all 79 Reviews, go directly to PubMed.
REVIEWS from PubMed – November 11, 2023 Obesity (in title) AND Colon or Rectum (in title) AND Cancer (in title) AND Review
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk October 8, 2024The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to […]Zoltan Ungvari
- Advancements in Understanding and Preventing Obesity-Related Colon Cancer September 23, 2024Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and […]Christine Shieh
- Obesity-Associated Colorectal Cancer August 29, 2024Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through the secretion of proinflammatory cytokines. In addition to an increased inflammatory response, obesity-associated cancer presents accrued molecular factors related to cancer characteristics, such as […]Lucia Gonzalez-Gutierrez
- Obesity and Colorectal Cancer: A Narrative Review August 29, 2024Background and Objectives: Cancer is a multicausal disease, and environmental, cultural, socioeconomic, lifestyle, and genetic factors can influence the risk of developing cancer. Colorectal cancer (CRC) stands as the third most common cancer globally. Some countries have observed a rise in the incidence of CRC, especially among young people. This increase is associated with lifestyle […]Bárbara Cristina Jardim Miranda
- Obesity and overweight are associated with worse survival in early-onset colorectal cancer May 21, 2024CONCLUSION: Individuals with early-onset colorectal cancer who are overweight or obese present with similar tumor characteristics and postoperative morbidity to patients with normal weight. However, obesity may have a detrimental impact on their survival. Addressing obesity as a modifiable risk factor might improve early-onset colorectal cancer prognosis.Pauline Aeschbacher
- Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms May 20, 2024Early-onset colorectal cancer (EOCRC) is defined as diagnosed at younger than 50 years of age and indicates a health burden globally. Patients with EOCRC have distinct risk factors, clinical characteristics, and molecular pathogenesis compared with older patients with CRC. Further investigations have identified different roles of obesity between EOCRC and late-onset colorectal cancer (LOCRC). Most […]Peng Xu
- Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer April 13, 2024Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer through the production of metabolites such as itaconate. Itaconate downregulates peroxisome proliferator-activated receptor gamma as a tumor-suppressing factor and upregulates anti-inflammatory cytokines in M2-like macrophages. […]Alexandra N Jones
- Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer trial study protocol: a randomised clinical trial of fibre-rich legumes targeting the gut microbiome, metabolome and gut transit time of overweight and obese patients with a history of noncancerous adenomatous polyps February 5, 2024INTRODUCTION: Recently published studies support the beneficial effects of consuming fibre-rich legumes, such as cooked dry beans, to improve metabolic health and reduce cancer risk. In participants with overweight/obesity and a history of colorectal polyps, the Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer randomised clinical trial will test whether a high-fibre diet featuring […]Terryl J Hartman
- Correction: Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses January 16, 2024No abstractMarko Mandic
- Visceral obesity and anastomotic leakage rates in colorectal cancer: a systematic review and meta-analysis September 6, 2023CONCLUSIONS: Our findings confirmed the significant relationship between VO and AL. Thus, VO could be considered a reliable risk factor of surgery for colon cancer.Linchong Yu
- Obesity and Colorectal Cancer August 25, 2023The prevalence of obesity has increased significantly worldwide, and this trend is likely to continue in the coming years. There is substantial evidence that obesity plays a crucial role in the development of colorectal cancer. Epidemiological data have consistently demonstrated a correlation between obesity and colorectal cancer. Insulin resistance, hyperinsulinemia, chronic inflammation, altered levels of […]Jundeok Lee
- Diagnosis and prevalence of sarcopenic obesity in patients with colorectal cancer: A scoping review July 22, 2023CONCLUSIONS: SO in patients with CRC was mainly diagnosed based on a combination of SMI and BMI, and muscle strength and body composition were rarely evaluated. The prevalence of SO was approximately 15%, depending on the diagnostic methods used. Since SO in patients with CRC is associated with poor prognosis, further research on diagnostic methods […]Yoko Saino
- The Impact of Bariatric Surgery on the Incidence of Colorectal Cancer in Patients with Obesity-a Systematic Review and Meta-analysis of Registry Data June 21, 2023CONCLUSION: At a population level, bariatric surgery is associated with reduced CRC risk in patients with obesity. GB and SG are associated with the most significant reduction in CRC risk.Matthew G Davey
- Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? April 13, 2023Obesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, and it has become a global problem. In 2018, there were around 1.8 million new […]Anna Maria Rychter
- Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer March 29, 2023The complexity and variety of gut microbiomes within and among individuals have been extensively studied in recent years in connection to human health and diseases. Our growing understanding of the bidirectional communication between metabolic diseases and the gut microbiome has also highlighted the significance of gut microbiome dysbiosis in the genesis and development of obesity-related […]Samradhi Singh
- Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis January 21, 2023Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through different mechanisms and highlighting an increase in cancer incidence in individuals with obesity. The aim of this […]Andrea Chierici
- Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses January 21, 2023Although high body-mass index (BMI) is associated with increased risk of developing colorectal cancer (CRC), many CRC patients lose weight before diagnosis. BMI is often reported close to diagnosis, which may have led to underestimation or even reversal of direction of the BMI-CRC association. We aimed to assess if and to what extent potential bias […]Marko Mandic
- Remodeling of the Gut Microbiota in Colorectal Cancer and its Association with Obesity January 19, 2023The considerable burden of colorectal cancer and the increasing prevalence in young adults emphasizes the necessity of understanding its underlying mechanisms and risk factors as well as providing more effective treatments. There is growing evidence of a positive relationship between obesity and colorectal cancer. Furthermore, the prominent role of gut microbiota dysbiosis in colorectal carcinogenesis […]Nima Zafari
- Sex-Dependent Differences in Colorectal Cancer: With a Focus on Obesity November 26, 2022Colorectal cancer (CRC) is the third most common cancer and has the second highest cancer-related mortality in the world. The incident rates of CRC vary country-wise; however, population studies and data from different countries show a general increase in the CRC rate in young adults, males, and females ≥65 years. CRC incidence is affected by […]Prachi Wele
- Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link? November 11, 2022Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized […]Alice Chaplin
To see all 358 Papers, Go directly to PubMed.
RECENT PAPERS from PubMed – November 11, 2023 Obesity (in title) AND Colon or Rectum (in title) AND Cancer (in title)
- Examination of Sarcopenia with Obesity as a Prognostic Factor in Patients with Colorectal Cancer Using the Psoas Muscle Mass Index October 16, 2024Background: Sarcopenia, the age-related loss of muscle mass, is a negative prognostic factor in gastrointestinal cancer. Sarcopenia combined with visceral obesity (sarcopenic obesity) is associated with poor outcomes. We explored the influence of obesity and other factors on the prognosis of patients with colorectal cancer diagnosed with sarcopenia. Methods: We enrolled 211 patients with colorectal […]Kengo Haruna
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk October 8, 2024The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to […]Zoltan Ungvari
- Obesity Promotes Marrow-Derived Myeloid Cell Accumulation while Exercise Reduces Proliferative Signaling in Colon Cancer October 1, 2024CONCLUSIONS: The results suggest that obesity promotes colon ACF formation, potentially through early inflammatory myeloid cell accumulation. Despite attenuating ACF, EX did not alter myeloid cell accumulation in the colon, suggesting that EX inhibits ACF formation through alternative mechanisms which may include reduced β-Catenin and STAT3 signaling.James J Vanhie
- Advancements in Understanding and Preventing Obesity-Related Colon Cancer September 23, 2024Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and […]Christine Shieh
- Increased expression of IL-1beta in adipose tissue in obesity influences the development of colon cancer by promoting inflammation September 21, 2024Excess adiposity contributes to the development of colon carcinoma (CC). Interleukin (IL)-1β is a pro-inflammatory cytokine relevant in obesity-associated chronic inflammation and tumorigenic processes. We herein aimed to study how obesity and CC affects the expression of IL1B, and to determine the impact of IL-1β on the regulation of metabolic inflammation and gut barrier function […]Gabriela Neira
- Obesity facilitated colon cancer progression is mediated by increased diacylglycerol o-acyltransferases 1 and 2 (DGAT1/2) levels September 19, 2024CONCLUSION: This is a novel mechanism of DGAT1/2-dependent metabolic and tumorigenic remodeling in obesity-facilitated colon cancer, providing a platform for the future development of effective treatments for colon cancer patients.Jenisha Ghimire
- Investigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort September 14, 2024CONCLUSIONS: Pre-diagnosis BMI trajectories were not associated with mortality after CRC diagnosis, whereas race/ethnicity, diabetes, and smoking were associated with an increased risk of death. Our findings suggest the obesity paradox alone does not account for mortality after CRC diagnosis.Shria Kumar
- Obesity-Associated Colorectal Cancer August 29, 2024Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through the secretion of proinflammatory cytokines. In addition to an increased inflammatory response, obesity-associated cancer presents accrued molecular factors related to cancer characteristics, such as […]Lucia Gonzalez-Gutierrez
- Obesity and Colorectal Cancer: A Narrative Review August 29, 2024Background and Objectives: Cancer is a multicausal disease, and environmental, cultural, socioeconomic, lifestyle, and genetic factors can influence the risk of developing cancer. Colorectal cancer (CRC) stands as the third most common cancer globally. Some countries have observed a rise in the incidence of CRC, especially among young people. This increase is associated with lifestyle […]Bárbara Cristina Jardim Miranda
- Laparoscopic vs. open surgery for rectal cancer in patients with obesity: short-term outcomes and relapse-free survival across age groups August 5, 2024CONCLUSION: Laparoscopic surgery offers short-term benefits for patients with obesity and rectal cancer compared to open surgery, regardless of age, without influencing the long-term prognosis.Yusuke Fujita
- Obesity and overweight are associated with worse survival in early-onset colorectal cancer: Reply July 23, 2024No abstractPauline Aeschbacher
- Obesity and overweight are associated with worse survival in early-onset colorectal cancer: A critical analysis of sample selection criteria July 7, 2024No abstractYa-Jie Wang
- Novel genetic association between obesity, colorectal cancer, and inflammatory bowel disease June 27, 2024CONCLUSION: The rs3184504 variant and the novel haplotype AGCAGT co-occurred in CRC, IBD, obesity, and inflammation. This novel haplotype could potentially be used in genetic panels to identify CRC/IBD susceptibility in obese patients.Morteza Gholami
- Mendelian randomization unraveled: gender-specific insights into obesity-related phenotypes and colorectal cancer susceptibility June 21, 2024CONCLUSION: Findings from this research indicate that specific obesity-related parameters, notably WHR and WHRadjBMI, carry a causal relationship with an elevated colorectal cancer risk. The impact is distinctly more evident among females. Such insights might be pivotal for public health deliberations, hinting that individuals boasting a high WHR might necessitate intensified colorectal cancer screenings.Xinyi Chen
- The impact of obesity on postoperative outcomes following surgery for colorectal cancer: analysis of the National Inpatient Sample 2015-2019 June 18, 2024CONCLUSION: Patients with obesity undergoing surgery for colorectal cancer may be at an increased risk of in-hospital postoperative morbidity. They may also be more likely to have increased hospitalization costs, post-operative ICU admissions, and to not be discharged directly home. Preoperative optimization via weight loss strategies should be further explored.Tania Kazi
- TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer June 5, 2024During the past half-century, although numerous interventions for obesity have arisen, the condition's prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlation with co-morbidities, such as colorectal cancer (CRC), which often thrives in an inflammatory tumor milieu. Of note, individuals with obesity commonly present with calcium […]Yanting Lin
- Obesity and overweight are associated with worse survival in early-onset colorectal cancer May 21, 2024CONCLUSION: Individuals with early-onset colorectal cancer who are overweight or obese present with similar tumor characteristics and postoperative morbidity to patients with normal weight. However, obesity may have a detrimental impact on their survival. Addressing obesity as a modifiable risk factor might improve early-onset colorectal cancer prognosis.Pauline Aeschbacher
- Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms May 20, 2024Early-onset colorectal cancer (EOCRC) is defined as diagnosed at younger than 50 years of age and indicates a health burden globally. Patients with EOCRC have distinct risk factors, clinical characteristics, and molecular pathogenesis compared with older patients with CRC. Further investigations have identified different roles of obesity between EOCRC and late-onset colorectal cancer (LOCRC). Most […]Peng Xu
- Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights May 4, 2024The identification of novel screening tools is imperative to empower the early detection of colorectal cancer (CRC). The influence of the long non-coding RNA maternally expressed gene 3 (MEG3) rs941576 single nucleotide polymorphism on CRC susceptibility remains uninvestigated. This research appraised MEG3 rs941576 association with the risk and clinical features of CRC and obesity-related CRC […]Mahmoud A Senousy
- Importance of circulating leptin and adiponectin in the causal pathways between obesity and the development of colorectal cancer in Japanese men April 21, 2024CONCLUSIONS: Our mediation analyses suggest that the association between BMI and CRC risk may be largely mediated by a pathway involving circulating leptin and adiponectin.Masataka Taguri
CLinical Trials involving Colorectal Cancer and Obesity
| NCT Number | Study Title | Study URL | Acronym | Study Status | Interventions | Sponsor | Collaborators | Enrollment | Study Type | Locations |
|---|---|---|---|---|---|---|---|---|---|---|
| NCT02843425 | The Beans to Enrich the Gut Microbiome vs. Obesity's Negative Effects (BE GONE) Trial | https://clinicaltrials.gov/study/NCT02843425 | ACTIVE_NOT_RECRUITING | OTHER: Regular Diet|OTHER: Navy Beans (Canned) | M.D. Anderson Cancer Center | 71 | INTERVENTIONAL | University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States | ||
| NCT04633512 | Safety and Feasibility of ActivSightTM in Human | https://clinicaltrials.gov/study/NCT04633512 | ENROLLING_BY_INVITATION | DEVICE: ActivSight | Activ Surgical | The University of Texas Health Science Center, Houston|University at Buffalo|Ohio State University | 67 | INTERVENTIONAL | Kaleida Health, University of Buffalo, Buffalo, New York, 14203, United States|Memorial Hermann Texas Medical Center, Houston, Texas, 77030, United States|Memorial Hermann Sugar Land Hospital, Sugar Land, Texas, 77479, United States | |
| NCT02269631 | Legume Diet Satiety Pilot Study | https://clinicaltrials.gov/study/NCT02269631 | COMPLETED | BEHAVIORAL: Legume diet group|BEHAVIORAL: Control diet group|DEVICE: Smartpill|OTHER: legumes | Emory University | 12 | INTERVENTIONAL | Morehouse, Atlanta, Georgia, 30310, United States|Emory ACTSI, Atlanta, Georgia, 30322, United States | ||
| NCT01312467 | Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI | https://clinicaltrials.gov/study/NCT01312467 | COMPLETED | DRUG: metformin hydrochloride | National Cancer Institute (NCI) | 45 | INTERVENTIONAL | Veterans Administration Long Beach Medical Center, Long Beach, California, 90822, United States|University of California Medical Center At Irvine-Orange Campus, Orange, California, 92868, United States|Kaiser Permanente - Sacramento, Sacramento, California, 95825, United States|Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada | ||
| NCT03548948 | Obesity, Iron Regulation and Colorectal Cancer Risk | https://clinicaltrials.gov/study/NCT03548948 | COMPLETED | OTHER: High heme iron diet|OTHER: Low iron diet|OTHER: Plant-based high non-heme iron diet | University of Illinois at Chicago | American Cancer Society, Inc. | 17 | INTERVENTIONAL | University of Illinois at Chicago, Chicago, Illinois, 60608, United States | |
| NCT04780477 | Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer | https://clinicaltrials.gov/study/NCT04780477 | RECRUITING | DIETARY_SUPPLEMENT: Experimental: High Fiber Diet (HFD)|DIETARY_SUPPLEMENT: Healthy American Diet | Emory University | National Cancer Institute (NCI) | 70 | INTERVENTIONAL | Rollins School of Public Health, Emory University, Atlanta, Georgia, 30322, United States | |
| NCT02273206 | Collaborative Care to Reduce Depression and Increase Cancer Screening Among Low-Income Urban Women | https://clinicaltrials.gov/study/NCT02273206 | PCM3 | COMPLETED | BEHAVIORAL: Prevention Care Management for Depression and Cancer Screening|BEHAVIORAL: Prevention Care Management for Cancer Screening | Clinical Directors Network | 802 | INTERVENTIONAL | Lincoln Ambulatory Care Practice, Bronx, New York, 10451, United States|Morrissania Diagnostic and Treatment Center, Bronx, New York, 10452, United States|Morris Heights Health Center, Bronx, New York, 10453, United States|Segundo Ruiz Belvis Diagnostic and Treatment Center, Bronx, New York, 10454, United States|BronwWorks, Bronx, New York, 10456, United States|Urban Health Plan, Bronx, New York, 10459, United States|Montefiore Family Care Center, Bronx, New York, 10467, United States|Good Shepherd Service, Bronx, New York, 10468, United States | |
| NCT04753359 | Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer | https://clinicaltrials.gov/study/NCT04753359 | Bridge CRC | RECRUITING | OTHER: Med|OTHER: WL | University of Illinois at Chicago | National Cancer Institute (NCI) | 232 | INTERVENTIONAL | University of Illinois at Chicago, Chicago, Illinois, 60612, United States |
| NCT00535990 | Minimally Invasive Surgery (MIS) Database for the Purpose of Research | https://clinicaltrials.gov/study/NCT00535990 | COMPLETED | University of California, San Diego | 250 | OBSERVATIONAL | University of California, San Diego, San Diego, California, 92103, United States | |||
| NCT05396846 | My Best GI Eating Study | https://clinicaltrials.gov/study/NCT05396846 | RECRUITING | BEHAVIORAL: Eating Plan 1|BEHAVIORAL: Eating Plan 2|BEHAVIORAL: Eating Plan 3 | University of Michigan | National Cancer Institute (NCI) | 240 | INTERVENTIONAL | University of Michigan, Ann Arbor, Michigan, 48109, United States | |
| NCT03976284 | Garden-fresh Produce and Exercise Reduce Colon Cancer Risk | https://clinicaltrials.gov/study/NCT03976284 | GFPE | UNKNOWN | BEHAVIORAL: Garden-fresh produce and exercise | University of California, Los Angeles | Charles Drew University of Medicine and Science | 21 | INTERVENTIONAL | UCLA Center for Cancer Prevention & Control Research, Los Angeles, California, 90095-6900, United States |
| NCT04068896 | Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy | https://clinicaltrials.gov/study/NCT04068896 | ACTIVE_NOT_RECRUITING | BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|OTHER: Placebo | NGM Biopharmaceuticals, Inc | 75 | INTERVENTIONAL | NGM Clinical Study Site, Tucson, Arizona, 85719, United States|NGM Clinical Study Site, Los Angeles, California, 90048, United States|NGM Clinical Study Site, Los Angeles, California, 90084, United States|NGM Clinical Study Site, Sacramento, California, 98517, United States|NGM Clinical Study Site, San Diego, California, 92123, United States|NGM Clinical Study Site, Santa Monica, California, 90404, United States|NGM Clinical Study Site, Aurora, Colorado, 80045, United States|NGM Clinical Study Site, Washington, District of Columbia, 20007, United States|NGM Clinical Study Site, Miami, Florida, 33136, United States|NGM Clinical Study Site, Chicago, Illinois, 60611, United States|NGM Clinical Study Site, Baltimore, Maryland, 21201, United States|NGM Clinical Study Site, Omaha, Nebraska, 68130, United States|NGM Clinical Study Site, Charlotte, North Carolina, 28204, United States|NGM Clinical Study Site, Cincinnati, Ohio, 45219, United States|NGM Clinical Study Site, Philadelphia, Pennsylvania, 19111, United States|NGM Clinical Study Site, Charleston, South Carolina, 29425, United States|NGM Clinical Study Site, Myrtle Beach, South Carolina, 29572, United States|NGM Clinical Study Site, Nashville, Tennessee, 37203, United States|NGM Clinical Study Site, Dallas, Texas, 75390, United States|NGM Clinical Study Site, Houston, Texas, 77030, United States|NGM Clinical Study Site, Seattle, Washington, 98101, United States|NGM Clinical Study Site, Milwaukee, Wisconsin, 53226, United States | ||
| NCT05732623 | Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer | https://clinicaltrials.gov/study/NCT05732623 | DEMETRA | RECRUITING | BEHAVIORAL: Semi Quantitative Food Frequency Questionnaire (SQFFQ) | San Raffaele University | Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy|Ospedale Civile Guglielmo da Saliceto, Piacenza, Italy|Centro di Riferimento Oncologico di Aviano, Aviano, Italy|Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy|Gastroenterology Unit, University Hospital of Padova, Padova, Italy|Clinical Gastroenterology Unit, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy|IRCCS Arcispedale S. Maria Nuova - Azienda Ospedaliera di Reggio Emilia, Reggio Emilia, Italy|Azienda Ospedaliera San Gerardo di Monza, Monza, Italy|Azienda ULSS5 Polesana, Rovigo, Italy|Istituto Tumori Regina Elena - IRCCS IFO, Roma, Italy|University Hospital of Padova, Padova, Italy|IRCCS De Bellis, Castellana Grotte, Italy|University Hospital HELIOS Klinikum Wuppertal, Center for Hereditary Tumors, University of Witten-Herdecke, Wuppertal, Germany|Hospital of the University of Munich (LMU), Campus Großhadern, Munich, Germany|Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain|Helsinki University Hospital, Helsinki, Finland|Oslo University Hospital (OUS), Institute for Cancer Genetics and Informatics Norwegian Radium Hospital, Oslo, Norway|Department of Medicine University of Chicago Medicine, Illinois, USA|University of Colorado Hospital, CO, USA|University of Michigan Ann Arbor, Michigan, USA|Columbia University Irving Medical Center, New York, NY|The James Comprehensive Cancer Center, Columbus, OH, USA|Ohio State University|Cleveland Clinic Main Campus, Cleveland, OH, USA|Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia | 2300 | OBSERVATIONAL | Department of Medicine-Gastroenterology, Denver Veterans Affairs Medical Center, University of Colorado Hospital, Denver, Colorado, 80045, United States|Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Chicago Medicine, Chicago, Illinois, 60637, United States|Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland|Department of General, Visceral and Transplant Surgery, Hospital of the University of Munich (LMU), Munich, Germany|Gabriela Moslein, Wuppertal, Germany|Prof Giulia Martina Cavestro, MD PhD, Milan, Lombardy, 20132, Italy|Division of Cancer Medicine, Oslo University Hospital (OUS), Institute for Cancer Genetics and Informatics Norwegian Radium Hospital, Oslo, Norway|Department of Gastroenterology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain |
| NCT00339469 | Effect of High-Legume Diet on Colorectal Cancer Risk | https://clinicaltrials.gov/study/NCT00339469 | COMPLETED | DIETARY_SUPPLEMENT: LIFE | National Cancer Institute (NCI) | 65 | INTERVENTIONAL | Pennsylvania State University, University Park, Pennsylvania, 16802, United States | ||
| NCT06117241 | Reducing Metabolic Dysregulation in Dyads | https://clinicaltrials.gov/study/NCT06117241 | REMEDY | RECRUITING | BEHAVIORAL: IMAGINE HEALTHY | University of South Carolina | 180 | INTERVENTIONAL | University of South Carolina, Columbia, South Carolina, 29208, United States | |
| NCT00653484 | Energy Balance Interventions for Colorectal Cancer Prevention | https://clinicaltrials.gov/study/NCT00653484 | COMPLETED | BEHAVIORAL: Physical Activity|BEHAVIORAL: Energy Restriction|BEHAVIORAL: Physical Activity and Energy Restriction | Vanderbilt University | National Cancer Institute (NCI) | 40 | INTERVENTIONAL | Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee, 37064, United States|Vanderbilt-Ingram Cancer Center at Franklin, Nashville, Tennessee, 37064, United States|Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, 37232-6838, United States | |
| NCT05114798 | Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers | https://clinicaltrials.gov/study/NCT05114798 | RECRUITING | BEHAVIORAL: Time restricted eating|BEHAVIORAL: Calorie Restriction | University of Illinois at Chicago | National Cancer Institute (NCI) | 255 | INTERVENTIONAL | University of Illinois at Chicago, Chicago, Illinois, 60612, United States | |
| NCT04540081 | Enhancing Electronic Health Systems to Decrease the Burden of Colon Cancer, Lung Cancer, Obesity, Vaccine-Preventable Illness, and LivER Cancer | https://clinicaltrials.gov/study/NCT04540081 | CLOVER | RECRUITING | OTHER: Epic Healthy Planet Population Health Module | University of California, Davis | University of California, Irvine | 20000 | INTERVENTIONAL | UC Davis Medical Center, Sacramento, California, 95817, United States |
| NCT01647776 | Screening and Risk Factors of Colon Neoplasia | https://clinicaltrials.gov/study/NCT01647776 | COMPLETED | OTHER: Stool DNA Test|PROCEDURE: biopsies of rectal and colon mucosa|OTHER: Questionnaires | Case Comprehensive Cancer Center | 3315 | OBSERVATIONAL | University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, 44106, United States | ||
| NCT01457976 | A Survey on Attitudes on Financial Incentives | https://clinicaltrials.gov/study/NCT01457976 | WITHDRAWN | University of Pennsylvania | 0 | OBSERVATIONAL | Online survey, Philadelphia, Pennsylvania, United States | |||
| NCT03286699 | Lifestyle Change for Better Health | https://clinicaltrials.gov/study/NCT03286699 | LCBH | ACTIVE_NOT_RECRUITING | BEHAVIORAL: Dietary Intervention|BEHAVIORAL: Physical Activity Intervention | University of Pittsburgh | National Cancer Institute (NCI) | 8 | INTERVENTIONAL | UPMC Shadyside, Pittsburgh, Pennsylvania, 15232, United States |
| NCT00032344 | Long-term Follow-up Study Designed to Evaluate the Relative Risk of Two Colonoscopy Schedules for Patients With Small Polyps | https://clinicaltrials.gov/study/NCT00032344 | COMPLETED | PROCEDURE: Colonoscopy | US Department of Veterans Affairs | 3200 | INTERVENTIONAL | Carl T. Hayden VA Medical Center, Phoenix, Arizona, 85012, United States|Southern Arizona VA Health Care System, Tucson, Tucson, Arizona, 85723, United States|VA Medical Center, Long Beach, Long Beach, California, 90822, United States|VA Palo Alto Health Care System, Palo Alto, California, 94304-1290, United States|VA Medical Center, San Francisco, San Francisco, California, 94121, United States|VA Eastern Colorado Health Care System, Denver, Denver, Colorado, 80220, United States|Edward Hines, Jr. VA Hospital, Hines, Illinois, 60141-5000, United States|VA Medical Center, Minneapolis, Minneapolis, Minnesota, 55417, United States|VA Medical Center, Kansas City MO, Kansas City, Missouri, 64128, United States|VA Medical Center, Durham, Durham, North Carolina, 27705, United States|VA Medical Center, Portland, Portland, Oregon, 97239-2964, United States|VA North Texas Health Care System, Dallas, Dallas, Texas, 75216, United States|VA Medical & Regional Office Center, White River, White River Junction, Vermont, 05009-0001, United States |