The provided text describes glucagon-like peptide-1 (GLP-1), detailing its production and the wide array of organs and systems it affects. Primarily, GLP-1 is generated in the intestinal L-cells and the brainstem’s nucleus of the solitary tract (NTS). Its influence is extensive, as GLP-1 receptors are distributed across the central nervous system, endocrine pancreas, cardiovascular system, and gastrointestinal tract. This hormone plays a crucial role in various bodily functions, including appetite regulation, insulin and glucagon secretion, gastric emptying, and cardiovascular health. In essence, the document outlines the origins and widespread physiological impact of GLP-1.
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