Bariatric Surgery
If you have been struggling with your weight, and diet and exercise have not yielded the desired results, there are a variety of options available to you, including bariatric surgery. Bariatric surgery may encompass a variety of procedures, which are collectively designed to help you lose weight. One common form of bariatric surgery is known as gastric bypass, which involves changing how your digestive system operates. Through these changes, your body may be better equipped to lose weight and maintain a healthier lifestyle. Bariatric surgery may also be recommended if you are experiencing health problems due to your weight. By speaking to your healthcare provider about the benefits and risks of these procedures, you can make a more informed decision about the best course of action for your personal health and wellness needs.
News

‘Gray Market’ Retatrutide Study; Menopause and the Brain; Drug Allergy Warnings
Wednesday, August 26 – (MedPage Today) — People who took “gray market” compounded retatrutide, an investigational triple hormone receptor agonist, achieved less weight loss with up to 12 months of treatment than clinical trial participants, a preprint study suggested…

Pharmacy Asks Court To Toss Novo Nordisk Semaglutide Suit
Wednesday, August 26 – A pharmacy asked a Texas federal judge to toss claims brought by Novo Nordisk Inc. accusing the pharmacy of illicitly compounding a lucrative weight-loss drug called semaglutide, saying Novo Nordisk’s complaint amounts to a grievance list against the compounding industry.

The Medicare GLP-1 Discount Has One Big Catch: Some Sick Patients Don’t Qualify
Wednesday, August 26 – (MedPage Today) — In January, Jeff La Marca got a prescription for the popular weight loss drug tirzepatide (Zepbound). But he couldn’t afford the $750 monthly price tag.
Then Medicare launched an 18-month pilot program that offers GLP-1 medications…

People’s bodies are changing in the age of Ozempic. How are we meant to talk about it?
Wednesday, August 26 – Discussing people’s bodies can be fraught. We asked eating disorder experts how to do so – or not – responsiblyIn the age of Ozempic and people being open about plastic surgery, discussion about people’s bodies is rife. At the same time, nobody seems quite sure how to talk about them, as shown by recent coverage of celebrities like Ariana Grande.It is a fraught topic. We asked eating disorder experts for guidelines to follow when talking about other people’s bodies, and how to do so without doing harm. Continue reading…

The Medicare GLP-1 Discount Has One Big Catch: Some Sick Patients Don’t Qualify
Wednesday, August 26 – The new Medicare GLP-1 Bridge program promises eligible beneficiaries access to popular weight loss drugs for as little as $50 a month. But for some, having the very medical conditions these drugs are approved to treat means they don’t qualify for the discount.

Roche bets up to $2.3B in Hanmi pact for next-gen weight loss drug
Tuesday, August 25 – Roche, through its subsidiary Genentech, will gain access to the investigational asset HM17321, which is designed to not only elicit weight loss but also improve lean mass.

Smart probiotics can sense high blood sugar and release GLP-1 on demand
Monday, August 24 – For people living with diabetes, managing blood sugar can mean constantly watching the clock, keeping meals and medications on schedule and staying alert to changes in glucose levels. While little can be done about timed meals, researchers have developed a biological system that detects rising blood sugar levels and automatically responds by releasing medication to bring glucose back down.

Novo Nordisk starts trialing lower maintenance doses of oral Wegovy
Saturday, August 22 – The Phase 3 study is evaluating two doses of Novo’s Wegovy pill in people with obesity or overweight in combination with a reduced-calorie diet and increased physical activity.

Ozempic does something unexpected to the brain’s hunger neurons
Saturday, August 22 – Ozempic may work in the brain in almost the opposite way scientists expected, activating hunger-linked neurons that appear essential for sustaining fat loss. The surprising discovery in mice could reveal new targets for developing even more effective obesity drugs.
Reviews
- Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007 Aug 23;357(8):753-61. doi: 10.1056/NEJMoa066603. PMID: 17715409.
- Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, Bucher HC, Nordmann AJ. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ. 2013 Oct 22;347:f5934. doi: 10.1136/bmj.f5934. PMID: 24149519; PMCID: PMC3806364.
- Courcoulas AP, Christian NJ, Belle SH, Berk PD, Flum DR, Garcia L, Horlick M, Kalarchian MA, King WC, Mitchell JE, Patterson EJ, Pender JR, Pomp A, Pories WJ, Thirlby RC, Yanovski SZ, Wolfe BM; Longitudinal Assessment of Bariatric Surgery (LABS) Consortium. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013 Dec 11;310(22):2416-25. doi: 10.1001/jama.2013.280928. PMID: 24189773; PMCID: PMC3955952.
- Brito JP, Montori VM, Davis AM. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations. JAMA. 2017 Feb 14;317(6):635-636. doi: 10.1001/jama.2016.20563. PMID: 28196240; PMCID: PMC5557277.
- Arterburn DE, Telem DA, Kushner RF, Courcoulas AP. Benefits and Risks of Bariatric Surgery in Adults: A Review. JAMA. 2020 Sep 1;324(9):879-887. doi: 10.1001/jama.2020.12567. PMID: 32870301.
References:
- Wikipedia Bariatric surgery. Accessed September 2023
- Agency for Healthcare Research and Quality. Accessed September 2023
- American Society for Metabolic and Bariatric Surgery. “Bariatric Surgery Procedures.” Accessed September 2023