Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a reported 5-year survival rate of approximately 13.3%, largely because of late diagnosis, rapid progression and resistance to treatment. GAIP-interacting protein C terminus 1 (GIPC1), overexpressed in PDAC, is a scaffolding protein that stabilizes multiple oncogenic receptors and signaling complexes involved in proliferation, survival, adhesion, migration and chemoresistance.
