Pediatric – COC.org

Pediatric Cancer - Obesity Reviews, Recent Papers, and Clinical Trials

REVIEWS from PubMed – November 12, 2023 – Cancer (in title) AND Obesity (in title) AND Pediatric (in title) AND Review

A cluster-randomized control trial targeting parents of pediatric cancer survivors with obesity: Rationale and study protocol of NOURISH-T January 30, 2021
Approximately 40-50% of pediatric cancer survivors (PCS) are overweight or obese; increasing their risk for metabolic syndrome and other negative long-term physical health complications. Using our successful pilot trial testing the preliminary feasibility and efficacy of NOURISH for Healthy Transitions (NOURISH-T), we refined our intervention, now NOURISH-T+, and will implement these refinements in this larger, […]
Marilyn Stern

RECENT PAPERS from PubMed – November 12, 2023 – Cancer (in title) AND Obesity (in title) and Pediatric (in title)

Factors impacting physical activity among post-treatment pediatric cancer survivors with overweight and obesity April 26, 2024
BACKGROUND: Pediatric cancer survivors (PCS) with overweight and obesity are at risk for various secondary chronic diseases. Although previous research has found physical activity (PA) as beneficial after treatment, the PA levels are low among PCS, highlighting the need for lifestyle interventions targeting PA.
Nashira I Brown
Challenges and adaptations for a cluster-randomized control trial targeting parents of pediatric cancer survivors with obesity during the COVID-19 pandemic November 3, 2022
Although the COVID-19 pandemic has increased the importance of digital technology in clinical trial implementation, there is a dearth of literature reporting on challenges and strategies related to multi-site randomized controlled trials (RCTs) among pediatric cancer survivors during the pandemic. This paper discusses challenges faced in the implementation of the NOURISH-T+ trial so far (December […]
Acadia W Buro
A cluster-randomized control trial targeting parents of pediatric cancer survivors with obesity: Rationale and study protocol of NOURISH-T January 30, 2021
Approximately 40-50% of pediatric cancer survivors (PCS) are overweight or obese; increasing their risk for metabolic syndrome and other negative long-term physical health complications. Using our successful pilot trial testing the preliminary feasibility and efficacy of NOURISH for Healthy Transitions (NOURISH-T), we refined our intervention, now NOURISH-T+, and will implement these refinements in this larger, […]
Marilyn Stern
Neighborhood effect and obesity in adult survivors of pediatric cancer: A report from the St. Jude lifetime cohort study October 11, 2019
Survivors of childhood cancer are at risk for obesity, a condition potentially modifiable if dietary intake and physical activity are optimized. These health behaviors are likely influenced by neighborhood of residence, a determinant of access to healthy, affordable food and safe and easy exercise opportunities. We examined associations between neighborhood level factors and obesity among […]
Carrie R Howell
Fatigue, Physical and Functional Mobility, and Obesity in Pediatric Cancer Survivors March 30, 2019
CONCLUSIONS: Findings showed that fatigue tends to improve over time after treatment but may be predicted by greater depression symptoms and lower mobility in recent survivors of childhood cancer.
Masoumeh Karimi
DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study November 2, 2018
Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) of body mass index (BMI) in the general population. We selected 96 ALL survivors from the Childhood Cancer […]
Philip J Lupo
NOURISH-T: Targeting caregivers to improve health behaviors in pediatric cancer survivors with obesity January 20, 2018
CONCLUSIONS: Results suggest that an intervention targeting parents is feasible and demonstrates preliminary effectiveness. NOURISH-T showed a longer term effect on caregivers, and, although shorter term effect, a positive impact on the PCS themselves. Implications for ways to improve NOURISH-T as an intervention for increasing healthy behaviors of PCS are discussed.
Marilyn Stern
The prevalence of overweight and obesity in pediatric survivors of cancer October 3, 2006
CONCLUSIONS: The prevalence of overweight was not increased in this cohort compared with the general population. However, almost 1/3 of these patients are overweight, necessitating a clinical and research focus on preventing and combating overweight in childhood cancer survivors.
Paul C Nathan

Clinical Trials involving Pediatric Cancers and Obesity

NCT Number	Study Title	Study URL	Acronym	Study Status	Interventions	Sponsor	Collaborators	Enrollment	Study Type	Locations
NCT00920738	Metabolic Syndrome in Childhood Cancer Survivors	https://clinicaltrials.gov/study/NCT00920738		COMPLETED	OTHER: metabolic assessment\|OTHER: questionnaire administration	University of Minnesota		512	OBSERVATIONAL	University of Minnesota Children's Hospital - Fairview, Minneapolis, Minnesota, 55455, United States
NCT05082519	Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL	https://clinicaltrials.gov/study/NCT05082519	IDEAL2	RECRUITING	BEHAVIORAL: IDEAL2 Intervention	Etan Orgel	Therapeutic Advances in Childhood Leukemia Consortium	240	INTERVENTIONAL	Children's Hospital Los Angeles, Los Angeles, California, 90027, United States\|Children's Hospital Orange County, Orange, California, 92868, United States\|UCSF School of Medicine, San Francisco, California, 94158, United States\|Colorado Children's Hospital, Denver, Colorado, 80045, United States\|Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia, 30322, United States\|Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, 60611, United States\|Johns Hopkins / Sydney Kimmel Cancer Center, Baltimore, Maryland, 21231, United States\|C.S. Mott University of Michigan, Ann Arbor, Michigan, 48109, United States\|Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, 55404, United States\|Columbia University Medical Center, New York, New York, 10032, United States\|Levine Children's Hospital, Charlotte, North Carolina, 28203, United States\|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States\|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States\|Oregon Health & Science University, Portland, Oregon, 97239, United States\|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States\|University of Texas, Southwestern, Dallas, Texas, 75235, United States\|Cook Children's Medical Center, Fort Worth, Texas, 76104, United States\|Baylor Texas Children's Hospital, Houston, Texas, 77030, United States\|Primary Children's Hospital, Salt Lake City, Utah, 84113, United States\|Children's Hospital of Wisconsin, Milwaukee, Wisconsin, 53226, United States
NCT04839952	Pilot Evaluation of a Healthy Lifestyle Intervention for Adolescent and Young Adult Survivors of Pediatric Cancer	https://clinicaltrials.gov/study/NCT04839952		COMPLETED	BEHAVIORAL: Healthy Lifestyles\|BEHAVIORAL: Education-Only Control	Johns Hopkins All Children's Hospital		59	INTERVENTIONAL	Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, 33701, United States
NCT00006515	Late Effects of Treatment for Sarcomas in Children	https://clinicaltrials.gov/study/NCT00006515		COMPLETED		National Cancer Institute (NCI)		39	OBSERVATIONAL	National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
NCT01365975	Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study	https://clinicaltrials.gov/study/NCT01365975		COMPLETED		National Cancer Institute (NCI)		1382	OBSERVATIONAL	National Cancer Institute (NCI), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
NCT01768533	Pediatric Behavioral Informatics to Prevent Cancer	https://clinicaltrials.gov/study/NCT01768533	TIDE	COMPLETED		University of Massachusetts, Boston		305	OBSERVATIONAL	UMass Boston, Boston, Massachusetts, 02155, United States
NCT04265638	Exercise Intervention in Adolescent and Young Adult Cancer Survivors	https://clinicaltrials.gov/study/NCT04265638		RECRUITING	BEHAVIORAL: Exercise	Indiana University		66	INTERVENTIONAL	IU Health North Hospital, Carmel, Indiana, 46032, United States\|Riley Hospital for Children - Indiana University, Indianapolis, Indiana, 46202, United States\|Indianapolis Healthplex, Indianapolis, Indiana, 46222, United States
NCT02815982	Targeting Caregivers to Enhance Health Behaviors in Pediatric Cancer Survivors	https://clinicaltrials.gov/study/NCT02815982	NOURISH-T	COMPLETED	BEHAVIORAL: NOURISH-T\|BEHAVIORAL: Enhanced Usual Care	University of South Florida	University of Pittsburgh\|Johns Hopkins All Children's Hospital	106	INTERVENTIONAL	Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, 33701, United States\|Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15224, United States
NCT05050539	Adaptive Implementation to Optimize Delivery of Obesity Prevention Practices in Early Care and Education Settings	https://clinicaltrials.gov/study/NCT05050539		RECRUITING	BEHAVIORAL: Low Intensity\|BEHAVIORAL: High Intensity	University of Arkansas	Louisiana Tech University	1850	INTERVENTIONAL	University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States
NCT05963971	A Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factors	https://clinicaltrials.gov/study/NCT05963971	PEDALL	RECRUITING	BEHAVIORAL: PEDALL\|OTHER: Standard of care	Columbia University		376	INTERVENTIONAL	Columbia University Medical Center, New York, New York, 10032, United States
NCT00124956	Doxorubicin Pharmacokinetic (PK) Study	https://clinicaltrials.gov/study/NCT00124956		WITHDRAWN	DRUG: Doxorubicin	Boston Children's Hospital	Glaser Pediatric Research Network\|Elizabeth Glaser Pediatric AIDS Foundation	0	INTERVENTIONAL	Children's Hospital, Boston, Boston, Massachusetts, 02115, United States
NCT02399956	Lactation Outcomes Among Survivors of Pediatric Cancer	https://clinicaltrials.gov/study/NCT02399956		COMPLETED	OTHER: Survey	St. Jude Children's Research Hospital		471	OBSERVATIONAL	St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States
NCT02501460	Impact of Resistance Training-Protein Supplementation on Lean Muscle Mass in Childhood Cancer Survivors	https://clinicaltrials.gov/study/NCT02501460		COMPLETED	OTHER: Educational handouts\|OTHER: Resistance training\|DIETARY_SUPPLEMENT: Supplementation\|OTHER: Placebo	St. Jude Children's Research Hospital	ATC Fitness\|American Institute for Cancer Research	130	INTERVENTIONAL	St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States
NCT04097353	Improving Health Behaviors for Pediatric Cancer Survivors	https://clinicaltrials.gov/study/NCT04097353		TERMINATED	BEHAVIORAL: Harvesting Hope for Kids (HH4K)\|BEHAVIORAL: Surviving Strong for Kids (SS4K)	Cynthia Gerhardt	Ohio State University	31	INTERVENTIONAL	Nationwide Children's Hospital, Columbus, Ohio, 43205, United States\|The Ohio State University, Columbus, Ohio, 43210, United States
NCT02476162	Assessing Blood Pressure Remotely in Childhood Cancer Survivors	https://clinicaltrials.gov/study/NCT02476162		COMPLETED	DEVICE: iHealth Wireless Blood Pressure Monitor	St. Jude Children's Research Hospital		60	OBSERVATIONAL	St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States
NCT03157323	Low GI Diet in Children and Adolescents With ALL	https://clinicaltrials.gov/study/NCT03157323		UNKNOWN	BEHAVIORAL: Low Glycemic Index Diet	Columbia University	American Cancer Society, Inc.\|Gabrielle's Angel Foundation	50	INTERVENTIONAL	Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States\|Children's National Hospital, Washington, District of Columbia, 20010, United States\|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States\|Columbia University, New York, New York, 10032, United States\|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
NCT05826184	Time Restricted Eating With or Without a Fiber Supplement for Weight Management in Pediatric Cancer Survivors	https://clinicaltrials.gov/study/NCT05826184		NOT_YET_RECRUITING	BEHAVIORAL: Time restircted eating\|BEHAVIORAL: Time restricted eating + prebiotic\|BEHAVIORAL: Control	University of Illinois at Chicago		45	INTERVENTIONAL	University of Illinois at Chicago, Chicago, Illinois, 60612, United States
NCT00504218	Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients	https://clinicaltrials.gov/study/NCT00504218		TERMINATED		Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)		62	OBSERVATIONAL	National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
NCT04656496	NOURISH-T+: Promoting Healthy Eating and Exercise Behaviors	https://clinicaltrials.gov/study/NCT04656496	NOURISH-T+	RECRUITING	BEHAVIORAL: NOURISH-T+\|BEHAVIORAL: Brief NOURISH-T+	University of South Florida	National Cancer Institute (NCI)	520	INTERVENTIONAL	Children's National Hospital, Washington, District of Columbia, 20010, United States\|University of Florida Health System, Gainesville, Florida, 32611, United States\|University of Miami Health System, Miami, Florida, 33136, United States\|Nicklaus Children's Hospital, Miami, Florida, 33155, United States\|USF Pediatrics, Tampa, Florida, 33612, United States\|Emory University, Atlanta, Georgia, 30322, United States\|Johns Hopkins Medicine, Baltimore, Maryland, 21287, United States\|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States\|Hackensack Meridian Health, Hackensack, New Jersey, 07601, United States\|Virginia Commonwealth University, Richmond, Virginia, 23298, United States