Lilly pads Zepbound data set, ponding the drum in obesity

Eli Lilly and Co. gained more oomph in its weight-loss battle with Novo Nordisk A/S, as the firm highlighted another batch of results from Surmount-5, a phase IIIb open-label trial evaluating the safety and efficacy of Zepbound (tirzepatide), a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 (GLP-1) receptor agonist compared to the Novo prospect Wegovy … Read more

What’s a New Drug Worth?

In a a juxtaposition of events that redefines the meaning of “coincidence,” President Trump announced a new policy for prescription drug pricing this morning, and the the Spring 2025 issue of the Journal of Economic Perspectives, released three days ago on Friday morning, begins with a four-paper symposium on drug pricing. (Full disclosure: I work … Read more

Trump issues executive order to slash drug costs: 7 notes

President Donald Trump signed an executive order May 12 directing drugmakers to sell medicines in the U.S. at prices similar to those offered in other wealthy countries, or face penalties and enforcement actions.  The move tasks HHS Secretary Robert F. Kennedy Jr. with setting target prices to bring U.S. drug costs “in line with comparably … Read more

Emerging Neuroprotective Potential of GLP-1 Receptor Agonists

For years, researchers had been searching for hormones that promote insulin secretion. These hormones, known as incretins, could be the key to helping treat type 2 diabetes (T2D). In the 1980s, glucagon-like peptide-1 (GLP-1) was found to be an incretin secreted by L-cells in the small intestine and to inhibit glucagon secretion. However, because of … Read more

Trump veers into erratic tale of ‘seriously overweight’ friend’s ‘damn fat drug’ struggle

In an erratic soliloquy before he signed an executive order to bring down the price of prescription drugs, President Donald Trump took aim at the “fat shot drug” he said was an example of how Big Pharma inflates the cost of medications. Trump was presumably talking about the popular GLP-1 drugs on the market under … Read more