Bariatric Surgery
If you have been struggling with your weight, and diet and exercise have not yielded the desired results, there are a variety of options available to you, including bariatric surgery. Bariatric surgery may encompass a variety of procedures, which are collectively designed to help you lose weight. One common form of bariatric surgery is known as gastric bypass, which involves changing how your digestive system operates. Through these changes, your body may be better equipped to lose weight and maintain a healthier lifestyle. Bariatric surgery may also be recommended if you are experiencing health problems due to your weight. By speaking to your healthcare provider about the benefits and risks of these procedures, you can make a more informed decision about the best course of action for your personal health and wellness needs.
News

Trump’s Latest Name For GLP-1s Has Doctors And Patients Raising An Important Concern
Despite the president’s comments, patients say these medications have been life-changing, and their effectiveness cannot be ignored.

Eli Lilly’s best-ever weight loss data; Sanofi, Regeneron re-up for $1B upfront; and more
Sunday, October 4 – Welcome back to another edition of Endpoints Weekly! It’s October 3rd, the day he asked me what day it was. “It’s October 3rd,” I told him.
This week we had a number of prominent deals …

AA: Pulmonary aspiration, regurgitation under anesthesia more likely with GLP-1 RAs
Saturday, October 3 – In the United Kingdom, 2.9% of patients undergoing anesthesia reported receiving glucagon-like peptide-1 receptor agonists (GLP-1 RAs), according to a study published online Sept. 16 in Anaesthesia to coincide with the annual meeting of the Association of Anaesthetists, held Sept. 16–18 in Liverpool, England.

Retatrutide Delivers Substantial Weight Loss in Type 2 Diabetes
Saturday, October 3 – (MedPage Today) — The investigational triple agonist retatrutide substantially improved glycemic control and body weight in adults with obesity and type 2 diabetes, a phase III trial showed.
Among 1,152 participants, average percentage of body…

Kailera, Hengrui’s GLP-1/GIP candidate delivers weight, menstrual benefits to women with PMOS
Saturday, October 3 – Kailera Therapeutics and Hengrui Pharma’s weekly injection showed benefits beyond weight loss in a mid-stage trial, leading to more regular menstrual cycles in patients with polyendocrine metabolic ovarian syndrome.

GLP-1s Tied to Detached Fingernails in New Study
Friday, October 2 – (MedPage Today) — Users of GLP-1 receptor agonists had as much as fourfold higher likelihood for nail disorders, particularly onycholysis (separation of the fingernails or toenails), compared with patients not taking the drugs, a large prospective…

GLP-1 prescriptions for new mothers have increased sharply
Friday, October 2 – More U.S. women are being prescribed GLP-1 medications after giving birth, particularly those diagnosed with diabetes, according to new research from the USC Schaeffer Center for Health Policy & Economics.

Novel GIP/GLP-1 Yields Uneven Findings in Diabetes Patients With Obesity
Friday, October 2 – (MedPage Today) — An investigational dual GIP/GLP-1 agonist achieved modest weight loss in adults with type 2 diabetes and obesity, the phase III SYNCHRONIZE-2 trial showed, but tolerability remains a concern.
Participants taking 3.6 mg and 6…

More New Moms Are Starting GLP-1 Drugs
Friday, October 2 – (MedPage Today) — Starting a GLP-1 receptor agonist after giving birth is becoming more common, an analysis of claims data showed.
The percentage of women who initiated a GLP-1 medication within 6 months of delivery rose more than 20-fold, from…
Reviews
- Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007 Aug 23;357(8):753-61. doi: 10.1056/NEJMoa066603. PMID: 17715409.
- Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, Bucher HC, Nordmann AJ. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ. 2013 Oct 22;347:f5934. doi: 10.1136/bmj.f5934. PMID: 24149519; PMCID: PMC3806364.
- Courcoulas AP, Christian NJ, Belle SH, Berk PD, Flum DR, Garcia L, Horlick M, Kalarchian MA, King WC, Mitchell JE, Patterson EJ, Pender JR, Pomp A, Pories WJ, Thirlby RC, Yanovski SZ, Wolfe BM; Longitudinal Assessment of Bariatric Surgery (LABS) Consortium. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013 Dec 11;310(22):2416-25. doi: 10.1001/jama.2013.280928. PMID: 24189773; PMCID: PMC3955952.
- Brito JP, Montori VM, Davis AM. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations. JAMA. 2017 Feb 14;317(6):635-636. doi: 10.1001/jama.2016.20563. PMID: 28196240; PMCID: PMC5557277.
- Arterburn DE, Telem DA, Kushner RF, Courcoulas AP. Benefits and Risks of Bariatric Surgery in Adults: A Review. JAMA. 2020 Sep 1;324(9):879-887. doi: 10.1001/jama.2020.12567. PMID: 32870301.
References:
- Wikipedia Bariatric surgery. Accessed September 2023
- Agency for Healthcare Research and Quality. Accessed September 2023
- American Society for Metabolic and Bariatric Surgery. “Bariatric Surgery Procedures.” Accessed September 2023