Emerging Therapies in Metabolic Health: A Comprehensive Review of GLP‐1, GIP, and Glucagon Agonists
This review talks about the development of incretin agonists (glucagon-like peptide-1 [GLP-1], GIP [glucose-dependent insulinotropic polypeptide], glucagon), oral formulation development approaches, and advanced drug delivery platforms. It provides details about clinical trials on incretin agonists, focussing on efficacy, safety, and innovations in clinical research. ABSTRACT Incretin-based therapies have become central to type 2 diabetes (T2D) […]
Ongoing lymphoid HIV production drives pyroptosis and GLP-1 counter-regulation in ART-suppressed infection
Despite effective antiretroviral therapy (ART), many people with HIV (PWH) exhibit persistent immune activation (IA) and suffer metabolic comorbidities. We investigated whether residual HIV production in lymphoid tissues drives IA. Among 20 ART-suppressed PWH, HIV RNA+ cells were detected in lymph nodes and correlated directly with markers of pyroptosis, assessed via cleaved gasdermin D positivity, […]
Jim Cramer on Procter & Gamble: “It Has the Opportunity to Shake Things Up”
The Procter & Gamble Company (NYSE:PG) is one of the stocks Jim Cramer talked about. During the episode, Cramer noted that it is one of the few consumer packaged goods companies that “doesn’t have a GLP-1 problem,” as he said: “I can go over how NVIDIA or Broadcom are down huge too much, and they’re […]
Amylyx Pharmaceuticals (AMLX) Announces the Selection of AMX0318 as Development Candidate for PBH and Other Rare Diseases
Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) is one of the best performing pharma stocks in 2025. Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) announced on January 8 the selection of AMX0318 as a development candidate for post-bariatric hypoglycemia (PBH) and other rare diseases. AMX0318 is a long-acting glucagon-like peptide-1 (GLP-1) receptor antagonist and was identified through a research collaboration with […]
“ONLY THESE PEOPLE SHOULD USE OZEMPIC”
Dr Benjamin Bikman explains that GLP 1 drugs slow digestion by increasing satiety hormones, sometimes leaving food in the stomach far longer than normal. This reduced digestion is why appetite drops, but it also causes common side effects like bloating and burping. He says the drugs are effective for weight loss but can also lead […]
The clock starts ticking the day you quit your GLP‑1 medication – Scripps News
The clock starts ticking the day you quit your GLP‑1 medication Scripps News People coming off weight-loss injections risk fast weight gain BBC Many people who come off GLP-1 drugs regain weight within 2 years, review suggests CNN Former GLP-1 users regain lost weight after about 18 months, study says The Washington Post Less than two years after stopping […]
Weight comes back quickly after quitting GLP-1 drugs: study
People who quit GLP-1 weight-loss medications like Ozempic regained just under one pound per month, a new report found. Researchers say they were projected to return to their original weight within nearly two years. »»» Subscribe to CBC News to watch more videos: http://bit.ly/1RreYWS For breaking news, video, audio and in-depth coverage: https://www.cbc.ca/news Follow CBC […]
Amazon (AMZN) Begins Selling Novo Nordisk’s Weight-Loss Pill – TipRanks
Amazon (AMZN) Begins Selling Novo Nordisk’s Weight-Loss Pill TipRanks Amazon Pharmacy starts offering Novo Nordisk’s Wegovy weight loss pill CNBC Oral Wegovy pill now available by prescription, Wisconsin experts brace for popularity WMTV 15 NEWS Wegovy Weight-Loss Pills Are Now Available in the U.S.—Here’s What That Means Scientific American How Does Oral Wegovy for Weight Loss Compare to GLP-1 […]
2026 is the year of obesity pills. Here’s how they could reshape the GLP-1 market
Patients can already access the first GLP-1 obesity pill from Novo Nordisk, and a rival oral drug from Eli Lilly is slated for U.S. approval later this year.
Weekly Dose of Optimism #175
Hey friends 👋 , Happy SATURDAY and welcome to a special weekend edition of the Weekly Dose. We’re sending today because we sent our deep dive on a16z yesterday, but let me know what you think about the weekend send. Might be a good way to spend a Saturday morning, coffee in hand, optimism in […]