[Comment] Ecnoglutide, a biased GLP-1 receptor agonist as a potential new player for type 2 diabetes management?

GLP-1 receptor agonists have been used to treat type 2 diabetes since 2005 and gained approval for weight management in 2014.1 However, a high between-individual heterogeneity should be acknowledged regarding the glucose-lowering potency and weight reduction efficacy. Furthermore, GLP-1 receptor agonists are associated with side-effects, especially gastrointestinal disturbances, leading some patients to prematurely abandon treatment. […]

[Articles] Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial

Once-weekly ecnoglutide 0·6 mg and 1·2 mg were non-inferior to dulaglutide 1·5 mg in reducing HbA1c in adults with type 2 diabetes and elevated glucose concentrations on metformin monotherapy. Although the 1·2 mg dose showed statistically significantly greater reductions in HbA1c from baseline to week 32 than dulaglutide 1·5 mg, the difference was not considered […]

What to know about pregnancy and GLP-1s as Serena Williams makes headlines

Serena Williams made headlines this week, not for her tennis court achievements, but for her health challenges since giving birth to her two children. She revealed she lost about 30 pounds by using a GLP-1 medication, such as Wegovy and Zepbound, through the telehealth company Ro. She serves as a paid spokesperson. CBS News’ Dr. […]

What to know about pregnancy and GLP-1s as Serena Williams makes headlines

Serena Williams made headlines this week, not for her tennis court achievements, but for her health challenges since giving birth to her two children. She revealed she lost about 30 pounds by using a GLP-1 medication, such as Wegovy and Zepbound, through the telehealth company Ro. She serves as a paid spokesperson. CBS News’ Dr. […]

FDA OKs First-Ever Glucose Monitoring System for Weight Loss: What to Know

The Signos system can be used alone, in combination with, or after GLP-1 drugs or bariatric surgery. Photography courtesy of Signos The FDA cleared the first glucose monitoring system specifically designed for weight management, from startup Signos, providing a new option for maintaining a healthy weight. The system uses a continuous glucose monitor, or CGM, […]