Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia
Although incretin (GLP-1)-based drugs are highly successful for weight loss, there are some limitations to their use. A modified prolactin-releasing peptide, NN501, causes significant weight loss without apparent side effects and with slower weight gain after cessation, potentially proving suitable as an alternative therapy for the treatment of obesity.
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans
Sebhat et al. present a strategy to mimic bariatric surgery by activating specialized intestinal cells that secrete satiety hormones, including GLP-1. Preclinically, a combination of gut-restricted agonists (K-833/K-757) induced synergistic hormone release that improved glucose tolerance and reduced body weight. In Ph1 trials, hormone levels surpassed those observed after surgery.
A Skeptic’s Guide to Ozempic and Other GLP-1 Agonists
A new compass for the SKEPDOC column. This column was founded by Harriet Hall, MD (1945–2023) who wrote it from 2006 to 2023. In 2026, we welcome William Meller, MD, to the helm. As an expert in evolutionary medicine, Dr. Meller will be our guide in navigating the deep biological history of our species to […]
Invesco vs. iShares: Which Consumer Staples ETF Is Better for Investors, PBJ or KXI?
Key Points KXI is more globally diversified, with nearly 100 holdings, but has a slightly deeper five-year drawdown than PBJ, and a weaker five-year total return. PBJ charges a higher expense ratio and focuses on U.S. food and beverage companies, while KXI covers the broader global consumer staples sector. KXI offers a higher dividend yield […]
Down 55%, Should You Buy the Dip on Pfizer?
Pfizer (NYSE: PFE) is in the Wall Street doghouse. It is currently viewed as an also-ran in the drug sector, lagging far behind peers like Eli Lilly (NYSE: LLY) in various categories, including the hot GLP-1 weight-loss drug space. With Pfizer’s shares trading down 55% from their coronavirus pandemic highs, some investors would rightly wonder […]
Medical Roundup #6
Published on January 19, 2026 9:20 PM GMT The main thing to know this time around is that the whole crazy ‘what is causing the rise in autism?’ debacle is over actual nothing. There is no rise in autism. There is only a rise in the diagnosis of autism. Table of Contents Autism Speaks. Exercise […]
Bariatric surgery beats GLP-1s for type 2 diabetes across income levels, study says
When endocrinologist Mary Elizabeth Patti looks at a patient with type 2 diabetes who could benefit from weight loss, she sees more than body mass index and blood glucose levels. She also recognizes the challenges of social vulnerability, understanding how low income, food insecurity, and limited access to health care might matter in treatment choice. […]
The Ozempic effect: How weight loss drugs are changing the menu at your favorite restaurant
Twelve percent of Americans reportedly take a GLP-1, according to a recent poll
Airlines have 580 million reasons to like GLP-1 weight-loss drugs, analysis finds
Airlines stand to save a potential $580 million as travelers slim down thanks to the effects of weight-loss drugs, a new study found. Sheila Kahyaoglu, an equity analyst at Jefferies and an author of the study, says the top four U.S. airlines, American Airlines, Delta Air Lines, Southwest Airlines and United Airlines, stand to save […]
The Weekly Whiskey 01/19/2025
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