GLP-1 Drugs Like Ozempic, Wegovy May Help Treat Anxiety, Depression

New research suggests that GLP-1s could offer dual benefits for treating both metabolic and mental health issues. Catherine Falls Commercial/Getty Images

A new study found that people taking GLP-1 drugs like Ozempic and Wegovy had a lower risk of worsening depression and anxiety.

The participants also had fewer hospitalizations and required less sick leave from their jobs.

Experts say the drugs’ effects on dopamine signaling and brain inflammation could account for the benefits.

It’s too soon to recommend GLP-1s as a primary treatment for mental health disorders. Further clinical trials are still needed.

FDA approves higher-dose Wegovy to help people lose more weight

A stronger version of the popular weight loss drug Wegovy is on the way after federal regulators signed off on a higher dose. The U.S. Food and Drug Administration (FDA) approved a 7.2-milligram dose of Novo Nordisk’s semaglutide, the active ingredient in Wegovy. Until now, the highest approved dose was 2.4 milligrams, taken as a weekly shot.

Weight loss drug Ozempic cuts depression, anxiety, and addiction risk

GLP-1 medications like semaglutide (Ozempic) may offer unexpected mental health benefits alongside weight loss. A large study found major drops in depression, anxiety, and psychiatric-related hospital visits among users. Even substance use disorders were significantly lower during treatment. Researchers suspect both lifestyle improvements and direct brain effects could be at play.