Unique and conserved endoplasmic reticulum stress responses in neuroendocrine cells
Endocrine cells are dedicated to the production and processing of hormones, from peptides to small molecules, to regulate key physiological processes, including glucose homeostasis and metabolism. Because of this relatively high productivity, endocrine cells must handle a variety of stresses from oxidative stress to the unfolded protein response of the endoplasmic reticulum (UPRER). While much […]
Novo’s Wegovy Cuts Cardio Risk by 57% Versus Tirzepatide
Novo Nordisk’s Wegovy has been on a winning streak as of late, with a metabolic dysfunction-associated steatohepatitis approval last month and prime position in the oral obesity race.
Could GLP-1 weight-loss medications like Ozempic become the ‘everything drug’?
GLP-1 agonists — including semaglutides like Ozempic and Wegovy and tirzepatides like Mounjaro and Zepbound — were originally intended to treat type 2 diabetes and obesity. But in recent months, studies have shown that these popular medications can have numerous other health benefits. Some have even claimed that GLP-1s could eventually become the new “everything […]
Why Some of the Most Important Money in Tech Might Be About to Disappear
From GPS to GLP-1 drugs, game-changing ideas often start with federal research dollars funding wacky experiments. Slashing it risks the trillion-dollar industries of tomorrow.
Lilly ends 2 of 3 mid-stage trials for oral GLP-1 contender naperiglipron
As the oral GLP-1 race intensifies, Eli Lilly has slimmed back the number of phase 2 trials it is conducting for one of its contenders.
Novo Shares Gain As Wegovy Shows Big Edge Over Lilly’s Tirzepatide In Heart Study
Novo Shares Gain As Wegovy Shows Big Edge Over Lilly’s Tirzepatide In Heart Study Novo Nordisk shares rose in Copenhagen trading on Monday after the pharmaceutical giant reported on Sunday that its weight-loss drug Wegovy reduced the risk of heart attack, stroke, or death by 57% compared with tirzepatide, the active ingredient in Eli Lilly’s […]
Biology, Vol. 14, Pages 1171: High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists
Biology, Vol. 14, Pages 1171: High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists Biology doi: 10.3390/biology14091171 Authors: Vanessa Touceda Leonardo Cacciagiú Ignacio Barbani Moglie Morena Wiszniewski Valeria Sanchez Romina C. De Lucca Agustina Vidal Paola Finocchietto Silvia Friedman Germán E. González Verónica Miksztowicz High salt (NaCl) intake has been associated […]
The next Ozempic: A 4-in-1 breakthrough for lasting weight loss
Scientists are racing to improve weight loss treatments beyond drugs like Ozempic and Wegovy, which are effective but plagued by nausea, bone loss, and weight regain. Tufts University chemists have created a new multi-target compound that goes beyond the usual GLP-1, GIP, and glucagon approaches by adding a fourth hormone, PYY. This “quadruple-action” design aims […]
The Ozempic effect: From shopping baskets to dips in Danish GDP
As GLP-1 use spreads, grocers and restaurants see lighter baskets, airlines predict fuel savings and health systems eye lower costs—while Denmark sees a clipped GDP.
How Novo Nordisk failed to protect its GLP-1 patent
Traditional intellectual property tools have proved insufficient against pharmacy compounders producing weight-loss drugs