GLP-1 psychological side effects: a psychiatrist’s view

As a physician-psychiatrist, I have watched the rise of GLP-1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) with genuine admiration. They are transforming metabolic health, reducing cardiovascular risk, and offering hope to patients who have struggled for decades. For many, these medications are lifesaving. But alongside the excitement, I’m witnessing something rarely discussed: a change in personality […]

Derek Thompson on 2025

I think this was a really bad year for American politics, a mediocre year for the American economy, and an exceptional year for America. In 12 months, you’ve got – the largest decline in murder rate ever recorded – huge declines in traffic fatalities, drug overdoses, and suicide – first ever personalized gene editing treatment […]

Heartbreakingly Shortsighted

Trump and his throwback henchmen have set scientific research back for decades. This piece from the Atlantic (gift link) spells it out and it’s just so depressing:  Some of those losses are straightforward: Since the beginning of 2025, “all, or nearly all, federal agencies that supported research in some way have decreased the size of […]