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Weight-loss drugs could reduce symptoms of painful skin condition, study finds

GLP-1 weight loss and diabetes drugs, like Ozempic and Wegovy, have been shown to reduce the symptoms of a painful skin condition. Hidradenitis suppurativa, also known as acne inversa, is a condition that causes small, painful lumps to develop under the skin, according to Mayo Clinic. These lumps typically develop in areas of the body […]

Impact of glucagon‐like peptide‐1 receptor agonists on the incidence of inflammatory bowel disease in people with type 2 diabetes

Abstract Aims To evaluate the association between the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and the likelihood of developing inflammatory bowel disease (IBD) and medical utilisation in individuals with type 2 diabetes mellitus (T2DM). Materials and Methods We used the TriNetX US collaborative network to identify 3 165 521 patients with T2DM from 1 January […]

Efficacy and safety benefits of HR17031, a fixed‐ratio combination of INS068 and noiiglutide, versus its components alone in Chinese patients with type 2 diabetes uncontrolled on oral antidiabetic drug(s): A phase 2, multicentre, open‐label, randomised, parallel three‐arm, treat‐to‐target trial

Abstract Aims To assess the efficacy and safety of HR17031, a fixed-ratio combination of basal insulin analogue (INS068) and GLP-1 receptor agonist (noiiglutide), versus its components alone in patients with type 2 diabetes uncontrolled on metformin with or without a second oral antidiabetic drug. Materials and Methods This phase 2 multicentre trial randomised 455 patients […]

Exercise improves endothelial progenitor cell’s function in mice with Type 2 diabetes via gut microbiota modulation

IntroductionEvidence has proved that exercise increases migration and tube formation of rat EPCs. But the mechanism behind the improved function of EPCs by exercise remains unclear.MethodsThis study conducted 8-week exercise interventions (aerobic, resistance, or combined) in 6-week-old type 2 diabetic mice, assessing post-exercise glucose, weight, GLP-1, and gut microbiota. Mice with optimal outcomes were selected […]

STAT+: Novo Nordisk links to telehealth providers for patients seeking Wegovy

Novo Nordisk has taken the next step in selling its drugs directly to patients by pointing them to telehealth providers that can write prescriptions for its popular obesity medication Wegovy. The company now links to select virtual providers on the NovoCare direct-to-patient pharmacy website it launched earlier this year, joining other pharma giants that have […]

Biomedicines, Vol. 13, Pages 2088: Impact of Prolonged Fasting and Refeeding on Enteroendocrine Hormone Expression: One More Piece of the Fasting/Refeeding Metabolic Puzzle

Biomedicines, Vol. 13, Pages 2088: Impact of Prolonged Fasting and Refeeding on Enteroendocrine Hormone Expression: One More Piece of the Fasting/Refeeding Metabolic Puzzle Biomedicines doi: 10.3390/biomedicines13092088 Authors: Gonçalo Nunes Marta Guimarães Sofia B. Oliveira Sofia S. Pereira Francisco Vara-Luiz Ivo Mendes Carolina Palma Cátia Oliveira Jorge Fonseca Introduction: Prolonged fasting induces histological and ultrastructural changes […]

Discovery of Glucagon-Like Peptide-1 and Its Biological Activity—Reply

In Reply We thank Dr Mojsov for her comments on our Viewpoint and for her contributions to the field. In our Viewpoint, we sought to provide a more complete chronology of events surrounding the discoveries related to GLP-1. As we noted, we were working in the Habener laboratory at MGH from 1984 to 1988, and […]