JCM, Vol. 14, Pages 6060: Treatment Landscape of Metabolic-Dysfunction-Associated Steatotic Liver Disease
JCM, Vol. 14, Pages 6060: Treatment Landscape of Metabolic-Dysfunction-Associated Steatotic Liver Disease Journal of Clinical Medicine doi: 10.3390/jcm14176060 Authors: Pranav Patel Background/Objectives: The incidence of metabolic-dysfunction-associated steatotic liver disease (MASLD) is on the rise worldwide. The purpose of this paper is to review the current and emerging trends in the management and treatment of this […]
Eli Lilly (LLY) Prepares for Weight Loss Pill Approval After Late-Stage Clinical Trial – TipRanks
Eli Lilly (LLY) Prepares for Weight Loss Pill Approval After Late-Stage Clinical Trial TipRanks Eli Lilly Ready to Seek Obesity Pill Green Light After Study Hits Goals The Wall Street Journal Eli Lilly’s weight loss pill orforglipron clears its latest trial, paving way for approval CNBC Eli Lilly’s oral GLP-1 pill may help people with Type 2 diabetes […]
GLP-1s and cancer: What to know
As researchers study the efficacy of GLP-1s like Ozempic and Mounjaro in treating dementia and other health issues with an eye toward expanding their usage, oncologists are looking at a GLP-1 role in cancer care. Several studies have shown the therapies — currently approved for Type 2 diabetes, weight loss, cardiovascular disease, kidney disease, liver […]
Does Lilly’s New Obesity Pill Data Put It Back in the Weight Game?
Eli Lilly and Company LLY announced top-line data from the third of the seven phase III studies evaluating orforglipron, its GLP-1 once-daily oral pill, in patients with type II diabetes and obesity. The ATTAIN-2 study, which was conducted in overweight and obese people with type II diabetes without food or water restrictions, met the primary and […]
Cardiovascular Effects and Tolerability of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis of 99,592 patients
Publication date: Available online 27 August 2025 Source: JACC Author(s): Mattia Galli, Stefano Benenati, Claudio Laudani, Beatrice Simeone, Gianmarco Sarto, Luis Ortega-Paz, Erica Rocco, Marco Bernardi, Luigi Spadafora, Domenico D’Amario, Ernesto Greco, Giacomo Frati, Massimo Federici, Roxana Mehran, Filippo Crea, Dominick J. Angiolillo, Sebastiano Sciarretta
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE
The microbial-derived bile acid tryptophan-conjugated cholic acid improves type 2 diabetes by promoting GLP-1 secretion in the intestine via activation of the orphan GPCR MRGPRE, revealing another candidate receptor for bile acids and its physiological and pathophysiological importance.
Amylyx’s old ALS drug fails in another neuro disease, focus turns to GLP-1
For all intents and purposes, Amylyx is now a GLP-1 biotech. The company’s now-withdrawn ALS drug, branded as Relyvrio and codenamed AMX0035, failed a Phase 2b study for a separate rare neurological disease called progressive …
What Your Patients Should Know About Traveling With GLP-1s
A healthcare provider’s guide to advising patients on GLP-1 travel: storage guidelines, temperature requirements, and managing side effects away from home. Medscape Medical News
GLP-1 Receptor Agonists, Obesity, and PsA: 5 Things to Know
As the connection between obesity, psoriasis, and PsA grows clearer, so does the potential of GLP-1 RAs. Explore their emerging role at the intersection of metabolism and immune-mediated disease. Medscape Rheumatology
Gastroenterology Insights, Vol. 16, Pages 32: Leptin, Nesfatin-1, Glucagon-like Peptide 1, and Short-Chain Fatty Acids in Colon Cancer and Inflammatory Bowel Disease
Gastroenterology Insights, Vol. 16, Pages 32: Leptin, Nesfatin-1, Glucagon-like Peptide 1, and Short-Chain Fatty Acids in Colon Cancer and Inflammatory Bowel Disease Gastroenterology Insights doi: 10.3390/gastroent16030032 Authors: Tamás Ilyés Paul Grama Simona R. Gheorghe Vlad Anton Ciprian N. Silaghi Alexandra M. Crăciun Background: Short-chain fatty acids (SCFAs) are produced by the colon microbiome and bind […]