Incretin Therapy: Bane Or Boon To Weight Loss

At a time when both international and domestic celebrities like Oprah Winfrey, Elon Musk, Rebel Wilson, Tracey Morgan, filmmakers Hansal Mehta and Karan Johar, plus star actors NTR Junior and Priyanka Chopra Jonas are becoming a talking point for their rapidly visible weight-loss programmes, speculations are rife over how they are pursuing their kilo-shedding goals. […]
Research funding has unexpected benefits. A lizard study led to Ozempic

In a new weekly video series, STAT’s @HoganAlex examines the stakes of ongoing court battles over NIH grant funding.
Bariatric surgery better than GLP-1 drugs for weight loss : ASMBS study

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Blind Spots: Comparing the Vision Costs of Weight-Loss Drugs

Although GLP-1 drugs make headlines for vision risks, other weight-loss medications carry their own eye-related side effects. Medscape Medical News
Blockbuster Weight-Loss Drugs Linked to Massive Spike in Depression, Anxiety, and Suicidal Behavior

Groundbreaking study of over 160,000 patients reveals GLP-1 drugs like Ozempic and Wegovy nearly double the risk of psychiatric disorders, with some patients showing a shocking 195% increase in major depression. While millions celebrate dramatic weight loss from trendy GLP-1 agonist drugs like Ozempic and Wegovy, a recent study has uncovered a dark side that […]
The Overlooked Connection Between GLP-1s, Obesity, and Eating Disorders

Gretchen Zimmermann, MBA, RD, VP of Clinical Strategy at Vida Health The false belief that people with obesity do not have eating disorders is one of the most harmful misconceptions in obesity care. In reality, individuals with obesity are at a high risk for eating disorders. The intersection of obesity, mental health, and disordered eating […]
The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity

ObjectiveTo investigate the effects of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on motor function, necroptosis, and neuroinflammation in the brain in mice with diabetic Parkinson’s disease (PD) and its possible mechanism.MethodsWe prepared a diabetic model with streptozotocin, followed by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced diabetic PD model, along with liraglutide or saline intervention, and the control group with […]
Tirzepatide and Brain Disease; Lamotrigine Warning Challenged; APOE4’s Links

(MedPage Today) — Tirzepatide (Mounjaro, Zepbound) may have neuroprotective mechanisms against Alzheimer’s disease and dementia, a review suggested. (Metabolic Brain Disease)
An instantaneous brain-to-voice neuroprosthesis helped a man with amyotrophic…
Bariatric surgery leads to greater weight loss than GLP-1 drugs after two years

Sleeve gastrectomy and gastric bypass were associated with about five-times more weight loss than weekly injections of GLP-1 receptor agonists semaglutide or tirzepatide, at the end of two years, according to a new head-to-head real-world study presented today at the American Society for Metabolic and Bariatric Surgery (ASMBS) 2025 Annual Scientific Meeting.
Psychiatric disorders less likely after weight-loss surgery than treatment with GLP-1s

People who have metabolic and bariatric surgery are significantly less likely to develop psychiatric disorders compared to those who take weekly injections of GLP-1 anti-obesity medications, according to a new study presented today at the American Society for Metabolic and Bariatric Surgery (ASMBS) 2025 Annual Scientific Meeting. Over a five-year period, the risk of developing […]