Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework
Background: We previously published a literature based pipeline for sepsis gene prioritization (PS3 and candidate genes) using an LLM enabled retrieval and judging framework. Here, we extend that work to ask whether these prioritized genes show independent clinical validity and whether the same strategy generalizes to a “drug/obesity/infection” setting. Methods: Using the original LLM guided […]
Jackée Harry Lost 50 Lbs. Using a GLP-1, Then Got a Facelift to Address Her ‘Sagging Neck’: ‘I Feel Renewed’ (Exclusive)
The actress opened up to PEOPLE about her “miraculous” weight loss
Eat One Avocado a Day — But ONLY If You Add This | Dr. Mandell
Most people know avocados are healthy. They are rich in fiber, potassium, and heart-friendly fats. But what rarely gets explained is that eating an avocado by itself leaves out a key piece of physiology that affects satiety, blood sugar control, nutrient absorption, and long-term metabolic health. In this video, I explain why adding one simple […]
Virginia university leads trial for post-GLP-1 weight drug
Fairfax, Va.-based George Mason University is leading a phase 2 clinical trial of ARD-201, an oral medication designed to help patients maintain weight loss after stopping GLP-1 treatments such as Ozempic and Wegovy. The university is one of six sites participating in the open-label trial of the experimental drug, developed by Aardvark Therapeutics, according to […]
GLP-1 drugs brought our eating disorders back — and quitting the shots doesn’t always help
“I never, ever thought that this would happen.”
Hormone therapy combined with tirzepatide linked to greater weight loss after menopause
A new study led by Mayo Clinic found that postmenopausal women receiving menopausal hormone therapy lost 35% more weight while taking tirzepatide, a Food and Drug Administration-approved drug for the treatment of overweight and obesity. The findings, published in The Lancet Obstetrics, Gynaecology, & Women’s Health, could expand treatment possibilities for millions of women struggling with obesity and obesity-related diseases after menopause.
JCM, Vol. 15, Pages 921: Residual Renal Risk in Diabetic Nephropathy Despite Contemporary Therapies
JCM, Vol. 15, Pages 921: Residual Renal Risk in Diabetic Nephropathy Despite Contemporary Therapies Journal of Clinical Medicine doi: 10.3390/jcm15030921 Authors: Reinhart Speeckaert Charlotte Delrue Marijn M. Speeckaert Background/Objectives: Diabetic kidney disease (DKD) is the most prevalent form of chronic kidney disease and kidney failure globally. In the last decade, RAAS inhibitors, SGLT2 inhibitors, GLP-1-receptor […]
Sun Pharma receives DCGI approval for generic version of semaglutide injection
Sun Pharmaceutical Industries announced that it has received approval from the Drugs Controller General of India (DCGI) to manufacture and market a generic version of semaglutide injection. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is indicated for chronic weight management in adults as an adjunct to a reduced calorie diet and increased physical activity.
Layer-by-Layer Polymeric Films: A Novel Approach to Buccal GLP-1 Delivery
Buccal delivery offers a promising alternative to oral drug administration by enabling direct systemic absorption and avoiding first-pass metabolism. Multilayer polymeric films represent a promising strategy for the sequential delivery of drug and absorption enhancer in the oral cavity. Here, dual- and triple-layer films were fabricated via slot-die coating, incorporating a GLP-1 receptor agonist (GLP-1-RA) […]
Ozempic Made Weight Loss Therapy Mainstream, But Now It’s Getting Competition
Who would have ever thought that a weight loss injectable would become a household name and pop culture-adjacent phenomenon? Ozempic has become synonymous with modern weight-loss, discussed just as casually as the latest iPhone or sneaker drop. But the era of semaglutide’s unquestioned dominance seems to be slipping with more and more weight loss drugs […]