A Revolutionary Drug for Extreme Hunger Offers Clues to Obesity’s Complexity

Ali Foley Shenk still remembers the panic when her 10-year-old son, Dean, finished a 20-ounce box of raisins in the seconds the cupboard was left unlocked. They rushed to the emergency room, fearing a dangerous bowel impaction. The irony stung: When Dean was born, he was so weak and floppy he survived only with feeding […]

Tirzepatide for Weight Loss in Non-Diabetics: A Meta-Analysis

Kommu S, Sharma PP, Gabor RM. Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Obes Rev. 2025 Jun 13:e13961. doi: 10.1111/obr.13961. Epub ahead of print. PMID: 40510020. This article presents a systematic review and meta-analysis on the efficacy and safety of tirzepatide for weight loss in […]

McDonald’s in Trouble as Ozempic Takes Hold

Broken ice cream machines aren’t the only thing bedeviling stalwart fast food chain McDonald’s. Financial services firm Redburn Atlantic put the company’s stock in the bear category, coinciding with a slumpy week in which it lost about three percent of its value — because analysts are betting that GLP-1 agonist weight loss drugs like Ozempic […]

The economics of GLP-1s from the pharmacy’s point of view

“Over the past year, my pharmacy spent $2m+ buying GLP-1s and lost $26k+ dispensing them.” I assumed pharmacies were also making a ton of money off the GLP-1 craze, but apparently not. Interesting read from the owner of CO Bigelow about how it looks from the pharmacy side. (Requires email signup)

Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Tirzepatide has positive effects on weight loss in individuals with overweight or obesity. Considering its broad side-effect profile, its efficacy and safety in individuals without diabetes mellitus (DM) are yet to be fully understood. To address this, we conducted a comprehensive meta-analysis of six randomized trials on individuals with overweight or obesity, without DM, […]