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GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesity; however, it is unknown whether the observed improvement in lymphatic function is solely due to weight loss-associated systemic benefits or in synergy with a lymphatic-specific effect of these […]

Ozempic isn’t about weight loss. It’s about food scarcity.

Alright, hear me out before you downvote me into oblivion. I’ve been thinking a lot about the sudden, aggressive push behind these GLP-1 drugs like Ozempic, Wegovy, etc. Yes, obesity is a real issue. Yes, these drugs help people. I’m not denying that. But I keep coming back to this question: Why this hard, this […]

$ISRG – Deciphering the Durability of a Surgical Revolution

$ISRG – Deciphering the Durability of a Surgical Revolution Intuitive Surgical, Inc. BATS:ISRG KalaGhazi Intuitive Surgical, Inc. (NASDAQ: ISRG) stands at a critical inflection point in its corporate narrative. The company’s third-quarter 2025 results, headlined by a robust 20% year-over-year growth in combined da Vinci and Ion procedures, have reignited a fundamental debate among investors: […]

Year Ender 2025 Special: From ‘Japanese Walking’ to ‘Oatzempic’, fitness and diet trends that broke the internet

In 2025, fitness and eating habits shifted towards long-term health. Japanese walking, Hyrox-style races, and power training became widely popular. AI trainers and fitness festivals began to replace traditional gym routines. Diet trends focused on fibre, gut health, and GLP-1 companion eating, while “swicy” flavours and fermented foods ruled kitchen trends. Overall, the year marked […]

How weight loss drugs are changing what Americans buy

New research from Cornell University reveals that GLP-1 weight-loss medications are significantly altering American shopping habits. Within six months of starting these drugs, individuals reduced grocery spending by an average of 5.3%, with higher-income households seeing over an 8% drop. Spending at fast-food and coffee shops also fell by approximately 8%.

Is ISRG’s 20% Procedure Growth the New Normal or a Peak?

Intuitive Surgical’s ISRG third-quarter results reignited the long-running debate around the durability of its growth engine. Combined da Vinci and Ion procedures rose 20% year over year in the third quarter of 2025, accelerating from roughly 18% growth in the first half. The top-line number is impressive — but the key investor question is whether […]

Weekend reading: How GLP-1 drugs are affecting food companies

Alert to readers: Amazon.com displays listings for several more workbooks, study guides, and cookbooks purportedly based on my book, What to Eat Now (see previous post on this).  I did not write any of them.  Caveat emptor! ___________________________ I’ve been collecting items on the effects of GLP-1 drugs on the food industry. Recall my mantra: Eating […]