Americans are obsessed with taking the ‘work’ out of working out
H. Armstrong Roberts/ClassicStock/Getty Images; BI Every generation has its own version of the vibrating belt machine — the ’50s-era contraption that promised to literally shake housewives into shape with minimal effort (and effect). This perpetual fitness obsession is why, on a recent Friday in June, I found myself strapped into the 2025 iteration: an electro-muscle […]
Incretin‐based therapies for individuals with obesity and heart failure with mildly reduced or preserved ejection fraction: A systematic review and meta‐analysis of randomized controlled trials
Abstract Aims Obesity is a major risk factor for heart failure with mildly reduced or preserved ejection fraction (HFpEF). This meta-analysis of randomised clinical trials (RCTs) evaluated the effects of incretin-based therapies (IBTs), including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GIP/GLP-1 RAs, on clinical outcomes in individuals with the obesity-HFpEF phenotype. Materials and […]
Current treatment guidelines and glycated haemoglobin goals for type 2 diabetes: Which patients are most likely to benefit from fixed‐ratio basal insulin glucagon‐like peptide‐1 receptor agonist combinations?
Abstract Basal insulin and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are available in two fixed-ratio combinations (FRCs) for the treatment of type 2 diabetes (T2D), insulin degludec with liraglutide and insulin glargine with lixisenatide. FRCs offer a convenient strategy to administer basal insulin and a GLP-1 RA, taking advantage of complementary mechanisms in a single […]
The weight loss drug Mounjaro has been approved to treat sleep apnoea. How does it work?
coldsnowstorm/Getty Images Last week, Australia’s Therapeutic Goods Administration (TGA) approved the weight-loss drug Mounjaro to treat sleep apnoea, a condition in which breathing stops and starts repeatedly during sleep. The TGA has indicated Mounjaro can be used to treat moderate to severe obstructive sleep apnoea in adults with obesity (a body-mass index of 30 or […]
Metsera Unveils First-in-Class Once-Monthly Amylin Candidate MET-233i’s Positive Phase 1 Results
Metsera, Inc. (NASDAQ:MTSR) is one of the 13 Biotech Stocks with Huge Upside Potential. Metsera, Inc. (NASDAQ:MTSR) reported encouraging Phase 1 results for MET-233i, its once-monthly amylin analog, which showed a mean weight loss of up to 8.4% at Day 36 after subtracting the placebo. A laboratory technician researching a sample of cells in a […]
LucyRx and Personify Health Partner to Offer Integrated GLP-1 and Weight Management Solution for Employers
What You Should Know: – LucyRx, an independent, next-generation pharmacy benefits manager (PBM), and Personify Health®, the company making healthier easier announced a strategic partnership to offer employers a more personalized, clinically grounded approach to GLP-1 medication management and weight care. – The strategic collaboration will deliver an integrated solution that combines pharmacy benefit strategy […]
Deep Apple signs big Novo deal for cardiometabolic small molecules
Deep Apple Therapeutics Inc. could bring in as much as $812 million in a new collaboration and license deal with Novo Nordisk A/S. The total includes an unspecified up-front payment, research costs and milestones. The two plan to develop and commercialize oral small molecules for non-incretin G-protein coupled receptor targets for treating cardiometabolic diseases, including […]
McDonald’s downgraded on GLP-1 drug worries: Wall Street’s top analyst calls
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Lawmakers urge Trump administration to clamp down on illicit GLP-1 sales
A bipartisan group of congressional lawmakers is calling on the Trump administration to address the continued sale of illicit, compounded GLP-1 products, warning that consumers may be accessing these drugs without knowing the product could be fraudulent. North Carolina Reps. Brad Knott (R) and Deborah Ross (D) wrote to Food and Drug Administration (FDA) Commissioner […]
Fatty Liver a Major Health Risk: Experts
Nonalcoholic fatty liver disease refers to a range of conditions in which fatty deposits occur in the liver. (Representational Image)Nonalcoholic fatty liver disease refers to a range of conditions in which fatty deposits occur in the liver. (Representational Image) �Hyderabad: Fatty liver disease, once considered a minor issue, has now emerged as a serious public […]