What Are ‘Ozempic Feet?’ Doctors Explain Latest GLP-1 Side Effect From Weight Loss

Friday, July 17 – Some people using GLP-1 drugs for weight loss have reported changes in their feet. Image Credit: stockvisual/Getty

“Ozempic feet” is the latest anecdotal side effect of GLP-1 drugs for weight loss.

The unusual phenomenon is a result of rapid weight loss, which may cause foot pain, changes in shoe size, and a more bony appearance in the feet.

Study identifies patients with obesity most likely to benefit from GLP-1-based treatment

Friday, July 17 – Why do some people lose substantial weight with GLP-1-based medications while others see more modest results? A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity that responds especially well to tirzepatide, a medication that mimics two naturally occurring hormones involved in appetite and blood sugar regulation, moving the field closer to precision medicine for obesity.

Rise of GLP-1s raises long-term affordability questions

Friday, July 17 – As use of GLP-1s surged across the U.S., average total payments per user also climbed sharply, according to a new Northwestern University study that analyzed national trends in GLP-1 use and spending between 2017 and 2022. These total payments included out-of-pocket costs paid by patients as well as payments from insurers, employers and government programs.

Ozempic-like drugs have more benefits to the body than just losing weight, meta-analysis shows

Friday, July 17 – A meta-analysis of 10 randomized controlled trials involving more than 23,000 participants, presented at the International Congress on Obesity (ICO 2026), hosted by the World Obesity Federation (WOF) in Mexico City, Mexico (July 15–17), shows that the GLP-1 class of obesity drugs is associated with a marked reduction in systemic inflammation beyond its anti-obesity effects, potentially explaining how the drugs can reduce cardiovascular risk factors.