Dry mouth, bad breath and tooth damage: The effects Ozempic and Wegovy can have on your mouth

Ozempic and Wegovy have been hailed as wonder drugs when it comes to weight loss. But as the drug has become more widely used, a number of unintended side-effects have become apparent—with the weight loss drug affecting the appearance of everything from your butt to your feet.
GLP-1 drugs may be linked to elevated risk of serious eye disease, study finds

People with diabetes who were taking GLP-1 drugs had a low but elevated risk of an age-related eye disease that can sometimes lead to blindness, a new observational study concludes, adding to a short list of concerns about eye health in people taking the powerful medications. The research, published Thursday in JAMA Ophthalmology, found that […]
MHRA Urges Contraception With GLP-1 Weight-Loss Drugs

Women using GLP-1 weight-loss drugs must use effective contraception, the MHRA has warned, citing unknown risks to pregnancy and foetal health. Medscape News UK
What is “Enforcement Discretion” (FDA context)?

Enforcement discretion means that a regulatory agency like the FDA (U.S. Food and Drug Administration) chooses not to enforce certain rules or regulations under specific circumstances, even if technically a violation has occurred. This is often done:• To avoid disrupting access to critical healthcare (e.g., during emergencies like COVID-19).• When the agency believes that the […]
Retatrutide: A Triple Agonist for Diabetes and Obesity

Abdul-Rahman T, Roy P, Ahmed FK, Mueller-Gomez JL, Sarkar S, Garg N, Femi-Lawal VO, Wireko AA, Thaalibi HI, Hashmi MU, Dzebu AS, Banimusa SB, Sood A. The power of three: Retatrutide’s role in modern obesity and diabetes therapy. Eur J Pharmacol. 2024 Dec 15;985:177095. doi: 10.1016/j.ejphar.2024.177095. Epub 2024 Nov 6. PMID: 39515565. Comprehensive narrative review focusing on retatrutide, […]
The “summer body” is over. Something worse is taking its place.

Women in bathing suits lined up on the beach in 1949. | FPG/Getty Images For decades, women have heard about the mythical “summer body” — toned arms, ripped abs, no cellulite. Some people also call this narrow goal “bathing suit ready,” or talk about having a “beach body.” In the months leading up to the […]
Q&A: Long-term success of GLP-1 therapies hinges on more than just a prescription

GLP-1 (glucagon-like peptide-1) therapies can be powerful tools in managing obesity, with patients taking these medications seeing weight reductions of 5%–18% in clinical trials, along with increased metabolism and benefits to their overall heart health. However, GLP-1s can come with challenges, including gastrointestinal side effects, risk of micronutrient deficiencies, muscle and bone loss, poor long-term […]
Weight loss drugs could make oral contraception less effective, MHRA warns

Women who take weight loss drugs should use barrier contraception if they are seeking to avoid pregnancy, the medicines regulator has advised.The Medicines and Healthcare Products Regulatory Agency has issued guidance warning that the drugs could reduce the effectiveness of oral contraceptives.1 The agency said it had received reports of 40 pregnancy related adverse events […]
GLP-1 study: Gencor running second trial after positive initial findings

STAT+: Pharmalittle: We’re reading about Novo Nordisk’s cautious culture, FDA approvals, and more

Good morning, everyone, and how are you today? We are doing just fine, thank you, despite rising temperatures and hazy skies looming over the Pharmalot campus. After all, the birds are still chirping and a cool breeze is wafting by. Moreover, our official mascots are snoozing somewhere on the premises. We can hear the heavy […]