RareFoldGPCR: Agonist Design Beyond Natural Amino Acids
Noncanonical amino acids (NCAAs) expand the chemical diversity of peptides beyond the twenty standard residues, offering new opportunities for designing binders with novel interaction modes and functional activity. G protein-coupled receptors (GPCRs) are central to cellular signalling and represent one of the largest classes of therapeutic targets, yet their functional modulation remains challenging. Here, we […]
Semaglutide Shows Safety in Patients on Dialysis
The study is the largest of its kind reporting on GLP-1 treatment in patients on dialysis, who are commonly excluded from clinical trials. Medscape Medical News
Semaglutide Shows Safety in Patients on Dialysis
The study is the largest of its kind reporting on GLP-1 treatment in patients on dialysis, who are commonly excluded from clinical trials. Medscape Medical News
Fitness Revolution Investment Thesis
I’m of the belief that a health revolution is gripping the young population of America and other developing nations, with people becoming far more conscious than generations past of what they put into their bodies as well as what physical exercise they perform. I think this is driven by a few different factors (in no […]
Can Novo Nordisk’s Restructuring Program Drive its Return to Growth?
In September 2025, Novo Nordisk NVO, under the leadership of its new CEO Mike Doustdar, unveiled a major restructuring plan designed to restore momentum in its core businesses and counter mounting competitive pressures. The plan, effective immediately, focuses on streamlining operations, accelerating decision-making speed and redeploying resources toward the company’s two main growth engines — […]
Menopause Weight Gain Is Common, but GLP-1s, Other Strategies Can Help
For some females experiencing menopause weight gain, dietary changes may not be enough on their own. Getty Images/Cultura Creative More women are seeking solutions to manage menopause symptoms like weight gain, highlighting a growing need for effective therapies and treatments. Lifestyle modifications like a healthy diet can help, but GLP-1 drugs have also emerged as […]
The GLP-1 Arms Race, Explained
The pharmaceutical boom in weight-loss drugs has put companies like Novo Nordisk and Eli Lilly in ever-fiercer competition. Now more heavyweights, like Pfizer and Astrazeneca, are entering the ring. Who will come out on top?
I bought ‘Godzilla’ jab on Facebook black market – it’s cheaper to buy than Mounjaro… I don’t care about deadly risks
HAND hovering over her computer keyboard, Nicki Hari clicks ‘buy’. But rather than splash out on a pair of new shoes or a fancy dress, Nicki’s latest online purchase could seriously endanger her health. Nicki Hari’s latest online purchase of an unlicensed weight loss jab could seriously endanger her healthSupplied RetatrutideShe’s just ordered a controversial […]
European Docs: GLP-1 Agonists Should Be First Obesity Option
GLP-1 agonists should be the first medicines doctors reach for to treat obesity and its complications, a major European medical association has advised. Reuters Health Information
Weight-loss surgery pros and cons in the spotlight after singer’s ‘scary’ experience
Amid the surge in GLP-1 weight-loss medications, some have questioned whether invasive procedures like lap band, gastric sleeve and bypass surgeries could wane in popularity. Carnie Wilson, of the band Wilson Phillips, recently shared her “very scary” experience on social media after having her laparoscopic adjustable gastric band (lap band) removed. The singer previously had […]