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Glucagon-like peptide-1 receptor agonists in arthritis: current insights and future directions

Nature Reviews Rheumatology, Published online: 01 October 2025; doi:10.1038/s41584-025-01302-0 Evidence is emerging that glucagon-like peptide-1 (GLP-1) receptor agonists have anti-inflammatory and chondroprotective properties independent of their effects on weight loss. In this Review, the authors discuss the potential effects of GLP-1 receptor agonists on the incidence, disease activity and progression of various forms of arthritis, […]

Federal shutdown begins as Trump warns Democrats of ‘irreversible’ consequences and more top headlines

1. Federal shutdown begins as Trump warns Democrats of ‘irreversible’ consequences 2. GOP targets Dems for ‘grinding America to a halt’ over shutdown 3. Trump says government may dismiss workers permanently after shutdown LAWYER UP – Charlie Kirk assassination suspect’s expanded defense team includes Menendez brother’s former attorney. Continue reading … HIGHWAY SWEEP – Oklahoma […]

Thatch

Welcome to the 2,123 newly Not Boring people who have joined us since our last essay! Join 251,962 smart, curious folks by subscribing here: Subscribe now Hi friends 👋 , Happy Wednesday! Since our last essay, we crossed the quarter-million subscriber mark. A huge thanks to all of you for reading Not Boring. Today’s Deep […]

Weight loss drug ‘Ozempic’ approved for use in India: Benefits and risks

India has officially approved Ozempic (semaglutide), a once-a-week injection for adults with type 2 diabetes, which also aids in weight loss. This GLP-1 receptor analogue helps control blood sugar, offers cardiovascular protection, and supports healthier eating habits. While promising for India’s rising diabetes rates, users should be aware of potential side effects.

GLP-1 is implicated in area postrema syndrome in people with NMOSD

Nature Reviews Neurology, Published online: 01 October 2025; doi:10.1038/s41582-025-01150-2 A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome in people with neuromyelitis optica spectrum disorder is related to elevated levels of the gut hormone glucagon-like peptide 1 and its receptor GLP-1R.

100% Pharmaceutical Tariffs Are Here. Time to Buy These 3 Drugmakers

Key Points 100% tariffs on branded pharmaceutical imports hit today, but exempting U.S. firms like the three stocks below.  A new pricing deal promises to stabilize costs, paving the way for pharma growth.  Pharma sector ETFs traded higher yesterday on relief. It sounds nuts, but SoFi is giving new active invest users up to $1k in stock, see […]

The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation

Selective and controlled expansion of endogenous β cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β cell proliferation to avoid excessive β cell expansion. Here, we identified a regulator of β cell proliferation whose inactivation resulted in controlled β cell expansion: the protein deacetylase sirtuin […]

Semaglutide shows potential to curb cocaine addiction behaviors

A new study published in European Neuropsychopharmacology suggests that semaglutide, a drug already used to treat type 2 diabetes and obesity, may also help reduce cocaine use, drug-seeking behavior, and relapse in preclinical models. The research found that semaglutide lowered both the motivation to consume cocaine and the amount taken by rats, while also dampening […]