Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Intentional Weight Loss and Associated Cancer Incidence Among People With Overweight or Obesity: A Systematic Literature Review September 13, 2025
CONCLUSIONS: This SLR highlights the potential cancer risk-reduction benefit of weight reduction for people with obesity.
Chi-Yin Liao
Targeting fatty acid-binding protein 4: A therapeutic intersection of obesity and cancer via lipid metabolism September 11, 2025
Fatty acid-binding protein 4 (FABP4) has emerged as a multifunctional regulator in cancer biology, linking dysregulated lipid metabolism, immune modulation, and tumor progression. Initially recognized for its role in fatty acid transport and lipid homeostasis, FABP4 is now understood as a secreted adipokine that influences diverse oncogenic processes, particularly in adipose-rich tumor microenvironments. It is […]
Katarzyna Smolińska
Obesity management in the setting of endometrial cancer and hyperplasia: A narrative review September 8, 2025
Obesity is a well-established risk factor for endometrial cancer, driven by chronic inflammation, insulin resistance, and excess estrogen. As the global obesity epidemic continues to worsen, effective weight management plays a crucial role in reducing both incidence and progression. Recent pharmacotherapy advancements, particularly GLP-1 receptor agonists, show promising weight loss effects by modulating appetite and […]
Natalie Moshayedi
Mammary Adipose Dysfunction in the Dual Epidemic of Obesity and Breast Cancer September 3, 2025
Breast cancer is one of the leading causes of death among women, with obesity being a significant factor. Mammary adipose tissue (MAT) dysfunction in obesity creates a tumor-supportive environment, leading to increased risk. In obesity, MAT undergoes significant changes, including increased adiposity, chronic inflammation, aromatase overexpression, insulin resistance, and altered adipokine signaling, collectively fostering a […]
Elvina Jeyakumar
GLP-1 Receptor Agonists in Breast Cancer: A New Frontier in Obesity and Prognosis Management August 28, 2025
Obesity is a well-established risk factor for both the incidence and poorer clinical outcomes of Breast Cancer (BC), particularly among hormone receptor-positive postmenopausal women. However, conventional weight loss interventions have yielded limited success in altering cancer prognosis. Recently, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide and tirzepatide, have emerged as effective pharmacologic agents […]
Juliana G Xande
Therapeutic Uses of Dietary Organosulfur Compounds in Response to Viral (SARS-CoV-2)/Bacterial Infection, Inflammation, Cancer, Oxidative Stress, Cardiovascular Diseases, Obesity, and Diabetes August 26, 2025
Phytonutrients are widely recognized for their protective health benefits in humans. Mounting studies suggest that dietary organosulfur compounds play a significant role in preventing various pathological conditions. Organosulfur compounds, such as diallyl disulfide, diallyl trisulfide, alliin, allicin, S-allyl cysteine, and sulforaphane, possess broad pharmacological activities, making them versatile therapeutic agents. Their antiviral, antibacterial, anti-inflammatory, anticancer, […]
Hiranmoy Barman
Oncogenic effects of ECM remodeling in obesity and breast cancer August 23, 2025
Extracellular matrix (ECM) components are key regulators in breast cancer progression, as ECM remodeling is essential for breast cancer cells to invade into surrounding tissue. This process is characterized by the alignment of fibrillar collagens, breakdown of basement membrane components, and increased interstitial collagen stiffness. In patients with obesity, pre-existing ECM changes, including excessive collagen […]
Mackenzie L Hawes
Impact of obesity on the short-term outcomes of robotic surgery for rectal cancer: a Japanese multicenter study August 22, 2025
CONCLUSION: Robotic surgery has shown good postoperative outcomes in obese patients, and it may, therefore, be useful in reducing complications, particularly in patients who have undergone prior treatment.
Hiroki Katayama
Cumulative abdominal obesity exposure and progressive risk of endometrial cancer in young women: a nationwide cohort study August 22, 2025
CONCLUSION: In this population-based nationwide cohort study of young women, we observed a progressive increase in the risk of endometrial cancer with cumulative abdominal obesity exposure.
Min-Kyung Lee
Evaluating the influence of the obesity paradox on survival outcomes in patients being treated surgically for rectal cancer-a systematic review and meta-analysis August 18, 2025
CONCLUSION: Once diagnosed and being treated with curative intent for rectal cancer, patients living with obesity exhibit similar survival outcomes as those living without obesity. This study refutes hypotheses that an 'obesity paradox' is protective for survival in patients with rectal cancer. Given the current obesity epidemic, this concept may warrant incorporation into preoperative counselling.
Matthew G Davey
Association between overweight and obesity determined by body mass index and overall survival in patients with metastatic prostate cancer: a meta-analysis August 15, 2025
CONCLUSION: Patients with mPC who have overweight or obesity, as defined by BMI, are associated with improved overall survival, particularly in those with mCRPC.
Feilun Cui
Adipose Stromal Cell Heterogeneity and Trafficking: Implications for Breast Cancer Metastasis and Obesity August 6, 2025
Adipose-derived stem cells (ASCs) have been extensively investigated for regeneration and tissue engineering applications owing to their inherent regenerative ability. However, the effects of various species and depot-specific extraction sites on ASC differentiation and renewal capacity have yet to be explored thoroughly, limiting the clinical use of ASCs. Despite promising clinical results, ASCs are also […]
Caroline R McCauley
The impact of sarcopenic obesity on the prevalence and prognosis of non-metastatic colorectal cancer: A systematic review and meta-analysis August 2, 2025
CONCLUSION: SO is linked to poorer survival and higher postoperative complications. Routine body composition assessments may aid early SO identification and intervention. Standardized diagnostic criteria and prospective studies are needed to refine prognostic evaluations.
Wanping Wang
A retrospective analysis of the association of obesity with anthracycline- and trastuzumab-induced cardiotoxicity in the treatment of breast cancer and lymphoma July 31, 2025
CONCLUSIONS: Obesity was not a significant risk factor for patients developing cardiotoxicity from trastuzumab- or anthracycline-based chemotherapy and may be a protective factor for cardiotoxicity. Additional studies with greater statistical power are needed to further evaluate this effect and independently evaluate obesity as a risk factor for cardiotoxicity.
Mallorie L Huff
Obesity-driven inflammation and cancer risk: A comprehensive review July 27, 2025
Obesity is a growing global health challenge, significantly increasing the risk of metabolic diseases and cancer. This review explores the link between obesity-driven inflammation and cancer risk, emphasizing the key biological mechanisms. Chronic low-grade inflammation in obesity, mediated by dysfunctional adipose tissue, promotes a pro-tumorigenic microenvironment through increased secretion of pro-inflammatory cytokines such as TNF-α, […]
D A Lamabadusuriya
The impact of obesity and lipids on cancer: Insights into mechanisms and potential interventions July 27, 2025
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes, are closely linked to different types of cancers. With obesity rates rising globally, its influence on cancer incidence and progression has become increasingly significant. The obesity-cancer axis is thought to be driven by a complex interplay of metabolic and immune factors, including adipokines, […]
Montserrat Romero
Central obesity increases the risk of breast cancer irrespective of menopausal status in women: Systematic review and meta-analysis July 25, 2025
CONCLUSION: This study revealed that central obesity is a risk factor of breast cancer. Interventions should be implement to reduce progression of breast cancer through lifestyle change. This study emphasises the need for breast cancer screening and treatment in individuals with central obesity.
Aboma Motuma
Cancer prevention and interception with antidiabetic and anti-obesity drugs: Current and future perspectives July 23, 2025
Obesity and type 2 diabetes are major risk factors for cardiovascular diseases and multiple malignancies, and epidemiology reveals an increasing burden of obesity-related cancers, in particular liver, pancreatic and endometrial. Obesity is also clearly associated with an increased risk of breast cancer, particularly in postmenopausal women. Chronic hyperinsulinemia, systemic inflammation, and metabolic dysregulation create a […]
Adriana Albini
Gastric Cancer and Obesity: Disease Occurrence and Perioperative Treatment July 17, 2025
With the increasing prevalence of obesity worldwide, the association between obesity and gastric cancer (GC) has gained significant attention. This review examines current research on the effects of obesity on GC risk, surgical outcomes, and prognosis. Findings indicate that obesity significantly increases risk of GC and substantially affects the perioperative treatment of patients with GC. […]
Ruixin Xu
Obesity-cancer axis crosstalk: Molecular insights and therapeutic approaches July 14, 2025
Now recognized as a global health crisis, obesity has been linked to an increased risk of many types of cancer, including those of the breast, colon, rectum, uterus, gallbladder, and ovary. Obesity and cancer share several characteristics at the cellular, molecular, and epigenetic levels. Obesity is characterized by chronic inflammation of the adipose tissue (AT), […]
Ahmed Rakib

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma