Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Overeating: A Conundrum of Lipid Metabolism and Inflammation in Obesity and Cancer October 28, 2025
The global rise in obesity has coincided with an alarming increase in early-onset cancers and other chronic noncommunicable diseases, underscoring the urgent need to understand the underlying mechanisms linking excess body weight with disease pathogenesis. While genetic factors account for disease risk, environmental and dietary influences, particularly those associated with Western hypercaloric diets, play a […]
Aizhan Surumbayeva
Effectiveness of sustained leisure-time physical activity strategies for obesity-related cancer prevention: an emulated target trial in a prospective US cohort October 27, 2025
CONCLUSIONS: We estimated that, compared to no intervention, sustaining MVPA volumes below recommendations may modestly increase obesity-related cancer risk over 11 years, whereas exceeding recommendations may modestly reduce risk, particularly among participants already meeting the recommendations prior to intervention.
Valeria Elahy
From obesity to oncology; bariatric surgery and the impact on breast cancer- what is the link? - A systematic review and meta-analysis October 22, 2025
CONCLUSION: This systematic review and meta-analysis demonstrates that bariatric surgery is associated with a statistically significant reduction in breast cancer incidence by pathways alluded to in this review and likely by a number of mechanisms yet to be fully elucidated. The role of menopausal status on breast cancer incidence in those who undergo bariatric surgery […]
Julie-Therese Clifford
Impact of obesity on breast cancer recurrence by menopausal status and subtype: a retrospective cohort study October 21, 2025
CONCLUSIONS: Obesity is a significant, potentially modifiable risk factor for recurrence in premenopausal females with luminal-type breast cancer.
K-H Yoon
Mapping the relationship between obesity and endometrial cancer: current research hotspots and future trends (2003-2024) October 20, 2025
CONCLUSION: This study comprehensively summarizes the knowledge structure of obesity and EC and identifies key research hotspots and trends. Based on our findings, the formation of a multidisciplinary team, the rational application of diagnostic and therapeutic techniques, the further enhancement of the exploration of the pathological mechanisms associated with obesity and EC as well as […]
Lei Liang
Effect of obesity on perioperative outcomes following lung cancer surgery: a systematic review and meta-analysis October 13, 2025
CONCLUSION: The obesity paradox may exist in patients undergoing lung cancer surgery. Although obesity is associated with longer operation duration, it neither increases the risk of complications nor prolongs hospital stays and is generally linked to reduced postoperative mortality.
Qiuxiang Wang
The predictive value of a body shape index as a novel obesity metric for cancer risk: a systematic review and meta-analysis October 10, 2025
CONCLUSION: ABSI demonstrates remarkable specificity for specific cancer types in cancer risk prediction. It independently predicts CRC risk, particularly in identifying high-risk male populations with central adiposity, serving as a beneficial supplementary tool to WC rather than a substitute. Available evidence does not support the routine application of ABSI for predicting prostate or breast cancer […]
Hui Liu
Vitamin D deficiency, supplementation, and colorectal cancer outcomes: interactions with obesity and risk profiles September 29, 2025
BACKGROUND: Vitamin D deficiency, colorectal cancer, and tumor progression are increasingly linked in recent research. Beyond its well-established roles in bone metabolism and immune regulation, vitamin D has emerged as a potential modulator of cancer prevention and prognosis, particularly in colorectal cancer, where deficiency may worsen outcomes.
Basmalah Ghazy
Microenvironmental determinants of cancer progression during obesity: emerging evidence and novel perspectives September 24, 2025
Obesity is a global pandemic representing a significant public health threat, with a rising number of affected individuals and numerous associated co-morbidities, including cancer. In obese cancer patients, higher mortality rates are usually observed compared to normal weight/lean individuals. The imbalanced metabolic asset of obese patients fosters tumor growth and its progression by impacting not […]
Rossella Salemi
Intentional Weight Loss and Associated Cancer Incidence Among People With Overweight or Obesity: A Systematic Literature Review September 13, 2025
CONCLUSIONS: This SLR highlights the potential cancer risk-reduction benefit of weight reduction for people with obesity.
Chi-Yin Liao
Targeting fatty acid-binding protein 4: A therapeutic intersection of obesity and cancer via lipid metabolism September 11, 2025
Fatty acid-binding protein 4 (FABP4) has emerged as a multifunctional regulator in cancer biology, linking dysregulated lipid metabolism, immune modulation, and tumor progression. Initially recognized for its role in fatty acid transport and lipid homeostasis, FABP4 is now understood as a secreted adipokine that influences diverse oncogenic processes, particularly in adipose-rich tumor microenvironments. It is […]
Katarzyna Smolińska
Obesity management in the setting of endometrial cancer and hyperplasia: A narrative review September 8, 2025
Obesity is a well-established risk factor for endometrial cancer, driven by chronic inflammation, insulin resistance, and excess estrogen. As the global obesity epidemic continues to worsen, effective weight management plays a crucial role in reducing both incidence and progression. Recent pharmacotherapy advancements, particularly GLP-1 receptor agonists, show promising weight loss effects by modulating appetite and […]
Natalie Moshayedi
Mammary adipose dysfunction in the dual epidemic of obesity and breast cancer September 3, 2025
Breast cancer (BC) is one of the leading causes of death among women, with obesity being a significant factor. Mammary adipose tissue (MAT) dysfunction in obesity creates a tumor-supportive environment, leading to increased risk. In obesity, MAT undergoes significant changes, including increased adiposity, chronic inflammation, aromatase overexpression, insulin resistance, and altered adipokine signaling, collectively fostering […]
Elvina Jeyakumar
GLP-1 Receptor Agonists in Breast Cancer: A New Frontier in Obesity and Prognosis Management August 28, 2025
Obesity is a well-established risk factor for both the incidence and poorer clinical outcomes of Breast Cancer (BC), particularly among hormone receptor-positive postmenopausal women. However, conventional weight loss interventions have yielded limited success in altering cancer prognosis. Recently, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide and tirzepatide, have emerged as effective pharmacologic agents […]
Juliana G Xande
Therapeutic Uses of Dietary Organosulfur Compounds in Response to Viral (SARS-CoV-2)/Bacterial Infection, Inflammation, Cancer, Oxidative Stress, Cardiovascular Diseases, Obesity, and Diabetes August 26, 2025
Phytonutrients are widely recognized for their protective health benefits in humans. Mounting studies suggest that dietary organosulfur compounds play a significant role in preventing various pathological conditions. Organosulfur compounds, such as diallyl disulfide, diallyl trisulfide, alliin, allicin, S-allyl cysteine, and sulforaphane, possess broad pharmacological activities, making them versatile therapeutic agents. Their antiviral, antibacterial, anti-inflammatory, anticancer, […]
Hiranmoy Barman
Oncogenic effects of ECM remodeling in obesity and breast cancer August 23, 2025
Extracellular matrix (ECM) components are key regulators in breast cancer progression, as ECM remodeling is essential for breast cancer cells to invade into surrounding tissue. This process is characterized by the alignment of fibrillar collagens, breakdown of basement membrane components, and increased interstitial collagen stiffness. In patients with obesity, pre-existing ECM changes, including excessive collagen […]
Mackenzie L Hawes
Impact of obesity on the short-term outcomes of robotic surgery for rectal cancer: a Japanese multicenter study August 22, 2025
CONCLUSION: Robotic surgery has shown good postoperative outcomes in obese patients, and it may, therefore, be useful in reducing complications, particularly in patients who have undergone prior treatment.
Hiroki Katayama
Cumulative abdominal obesity exposure and progressive risk of endometrial cancer in young women: a nationwide cohort study August 22, 2025
CONCLUSION: In this population-based nationwide cohort study of young women, we observed a progressive increase in the risk of endometrial cancer with cumulative abdominal obesity exposure.
Min-Kyung Lee
Evaluating the influence of the obesity paradox on survival outcomes in patients being treated surgically for rectal cancer-a systematic review and meta-analysis August 18, 2025
CONCLUSION: Once diagnosed and being treated with curative intent for rectal cancer, patients living with obesity exhibit similar survival outcomes as those living without obesity. This study refutes hypotheses that an 'obesity paradox' is protective for survival in patients with rectal cancer. Given the current obesity epidemic, this concept may warrant incorporation into preoperative counselling.
Matthew G Davey
Obesity and gastrointestinal cancer: A converging epidemic with surgical consequence August 16, 2025
Obesity is now a recognised carcinogen with growing implications for gastrointestinal surgical oncology. Excess adiposity promotes tumourigenesis through endocrine, inflammatory, and mechanical pathways, contributing to increased cancer incidence, stage at diagnosis, and worse oncological outcomes. For patients undergoing gastrointestinal cancer surgery, obesity adds significant technical complexity and elevates perioperative morbidity. While effective interventions such as […]
Rathin Gosavi

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma