Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Adipose-Derived Stem Cells at the Crossroads of Obesity and Cancer July 3, 2025
Obesity is a major concern for public health and is associated with a higher risk of various types of cancer. Understanding the fundamental mechanisms of this relationship is essential for effective cancer prevention and treatment. Adipose-derived stem cells (ADSCs) are a specialized subtype of mesenchymal stem cells (MSCs) extracted from adipose tissue. These cells have […]
Ahmad Reza Panahi Meymandi
SREBP-1 in obesity-induced breast cancer: mechanisms and therapeutic perspectives July 2, 2025
Breast cancer is the most prevalent form of malignant cancer among women worldwide, and obesity is a significant risk factor. Sterol regulatory element-binding protein 1 (SREBP-1) is a crucial transcription factor that governs lipid synthesis and is aberrantly activated in obesity-induced breast cancer. This review examines the intricate relationship between SREBP-1, obesity, and breast cancer, […]
Urvashi Tiwari
Wound Complications in Patients with Overweight, Obesity, and Gynecologic Cancer: A Retrospective Analysis of Staple Versus Suture Closure July 1, 2025
Background: Wound complications in gynecologic oncology, especially among patients with overweight and obesity, can significantly impact post-operative recovery and delay the initiation of adjuvant treatment. Although staples are commonly used for vertical incisions, sutures may offer clinical advantages; however, direct comparative data remain limited. This study aimed to compare post-operative wound complication rates between staples […]
Fatma Ceren Güner
Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1-98 and ATAC trial data July 1, 2025
Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1-98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by […]
Sixten Harborg
Navigating the weight: The impact of obesity on gastrointestinal cancer surgery and strategies for improved outcomes June 28, 2025
Obesity significantly affects gastrointestinal cancer surgery outcomes by creating complex challenges throughout the preoperative, intraoperative, and postoperative stages. This narrative review explores the intricate relationship between obesity and GIC surgery, highlighting the dual burden of obesity as a global public health issue and a determinant of surgical complications. The review aims to analyze physiological and […]
Gerardo Sarno
How Obesity Complicates Breast Cancer Care: Insights From a Systematic Review of Case Reports June 26, 2025
The global rise in obesity has intersected with increasing breast cancer incidence, generating a critical need to understand how excess adiposity affects diagnostic accuracy, treatment delivery, and patient outcomes. Although large epidemiologic studies have established associations between obesity and worse breast cancer prognosis, individual-level clinical nuances remain underrepresented. This review systematically evaluates case-based evidence to […]
Adam M Bowen
The Relationship Between Obesity and Cancer: Epidemiology, Pathophysiology, and the Effect of Obesity Treatment on Cancer June 25, 2025
There is growing evidence relating to the risk of cancer in people with obesity. Obesity is already established as one of the strongest predisposing factors to cancer, and 'obesity-related' cancers have been defined in previous studies. In this review article, we examine the epidemiological relationship and describe the potential pathophysiological mechanisms that underpin the association […]
Yasmin Ingram
Obesity and cancer: unravelling the microbiome's hidden role June 24, 2025
Obesity has been implicated as the driving force of many diseases including cancer through multiple biological mechanisms, including gut microbial imbalances, compromised intestinal barrier integrity, persistent low-grade inflammation, and alterations in energy uptake. As lifestyle factors such as diet, physical activity, and sleep are known to influence disease susceptibility, understanding the role of the gut […]
Christine Gaskell
Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview June 16, 2025
The steadily increasing prevalence of obesity and its association with a growing number of malignancies, including breast cancer, has made this disease spectrum an urgent and critical public health priority, demanding immediate attention and comprehensive action. To date, a growing body of research has been dedicated to the study of obesity/breast cancer biological link, with […]
Cinzia Giordano
Thematic issue: Obesity-driven cancer: Clinical and molecular aspects June 15, 2025
Obesity-associated insulin resistance (IR) is characterized by a chronic low-grade inflammatory state driven by adipocyte dysfunction, elevated free fatty acids, and proinflammatory cytokines. These factors activate signaling pathways-including JNK, TLR, and NF-κB-that impair insulin receptor function and promote hyperinsulinemia. Elevated insulin reduces insulin-like growth factor binding proteins, thereby increasing the bioavailability of IGF-1 and IGF-2, […]
Emmanuel Jacobo-Tovar
Murine Models of Obesity-Related Cancer Risk June 13, 2025
Obesity is a global menace that has impacted over 14% of adults worldwide and over a third of Americans. Importantly, obesity is associated with an increased risk of over 13 types of cancer and worse outcomes, including increased mortality. This review focuses on the importance of considering obesity and metabolic dysfunction in cancer risk as […]
Lukmon M Raji
Weighty matters: Unraveling the impact of obesity on colorectal cancer and nutritional interventions June 7, 2025
This narrative review explores the influence of obesity on colorectal cancer, focusing on obesity-related factors, including chronic inflammation, metabolic dysregulation, and gut microbiota imbalance, which collectively create a pro-carcinogenic environment that increases colorectal cancer risk and complicates treatment outcomes. The findings indicate that obesity not only accelerates tumor progression but also presents challenges in colorectal […]
Daniel Simancas-Racines
"Time" for obesity-related cancers: The role of chrononutrition in cancer prevention and treatment June 5, 2025
Obesity-related cancers are increasing globally, driven by metabolic disturbances and circadian rhythm disruptions. Circadian rhythms regulate physiological processes, and their misalignment has been linked to increased cancer risk. Chrononutrition, which aligns dietary intake with the body's circadian clock, has emerged as a potential strategy for cancer prevention and treatment. This review explored the intricate relationship […]
Ludovica Verde
Impact of Obesity on Cancer-Specific Survival and Overall Survival in Colorectal Cancer June 4, 2025
Obesity is a well-established risk factor for colorectal cancer (CRC) development, yet its influence on cancer-specific survival (CSS) and overall survival (OS) remains paradoxical. While obesity correlates with adverse outcomes such as increased recurrence, metastasis, and treatment-related complications, emerging evidence highlights a counterintuitive "obesity paradox," where overweight and moderately obese patients with Body Mass Index(BMI […]
Elvis Obomanu
Epitranscriptomic Role of m6A in Obesity-Associated Disorders and Cancer Metabolic Reprogramming May 28, 2025
The global rise in obesity and its associated metabolic disorders underscores the need for a deeper investigation into their underlying molecular mechanisms. While genetic factors are well-established contributors, recent research has increasingly focused on epigenetic regulators, particularly N6-methyladenosine (m⁶A)-the most prevalent internal RNA modification in eukaryotes. This post-transcriptional modification plays a crucial role in RNA […]
Sujun Yan
The correlation between obesity and the occurrence and development of breast cancer May 25, 2025
This study reviews the mechanisms by which obesity affects the development and progression of breast cancer (BC). The association between obesity and BC is mainly due to three aspects: disruption of glycolipid metabolism, abnormal cell function and imbalance of adipokine levels. The dysregulation of glycolipid metabolism caused by obesity, including the accumulation of cholesterol and […]
Jun-Jie Hu
Impact of obesity on postoperative complications in colorectal cancer surgery: A systematic review and meta-analysis May 24, 2025
CONCLUSION: Obesity significantly increases the risk of surgical site infections in colorectal cancer surgery. Although its impact on mortality and gastrointestinal complications remains unclear, implementing preoperative optimization protocols specifically aimed at obesity management could mitigate these surgical risks. The certainty of evidence ranges from low to very low, highlighting the need for high-quality prospective studies […]
Gerardo Sarno
Perceptions of cancer risk communication in individuals with overweight or obesity- a qualitative interview study May 23, 2025
CONCLUSION: Participants experienced that risk information, when presented as simplified associations between obesity and cancer, felt personally relevant but difficult to act upon, and therefore burdensome to bear. Consequently, the information risks failing to prevent cancer and may instead cause harm to the people it purports to benefit. Participants suggested several ways to improve the […]
Grauman Åsa
Impact of visceral obesity on postoperative outcomes in colorectal cancer: a systematic review and meta-analysis May 21, 2025
CONCLUSIONS: Colorectal cancer patients with VO who have surgery tend to have fewer lymph nodes taken, more problems after surgery, and a higher rate of switching to open surgery.
Yulong Wang
Evaluating the obesity paradox in patients with sepsis and cancer May 12, 2025
CONCLUSIONS: The obesity paradox is evident in both short-term outcome (28-day mortality) and long-term outcomes (6-month and 1-year mortality) among patients with sepsis and cancer, particularly in those presenting with lower disease severity. These findings highlight the need for personalized treatment approaches in this complex patient population.
Chunhong Hou

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma