Related Cancers – CancerObesityConnection.org

Cancer & Obesity Reviews (20 of the most recent)

Obesity as a Systems-Level Driver of Cancer: Mechanisms and Nutritional Reprogramming December 30, 2025
Obesity has emerged as a global health crisis and a potent driver of cancer incidence and mortality, yet its mechanistic impact on tumor biology remains underappreciated. Far from being a passive risk factor, obesity acts as a systems-level oncogenic stressor, reshaping hormonal signaling, immunometabolism, and epigenetic stability across the body. This review synthesizes current knowledge […]
Camelia Munteanu
Obesity is a major modifiable factor associated with ER-negative breast cancer: epidemiological and mechanistic evidence from a high-risk cohort December 30, 2025
No abstract
Naser Elkum
Multi-modal molecular and spatial profiling reveals NNT as a prognostic biomarker in obesity-associated colorectal cancer December 28, 2025
CONCLUSIONS: Through integrative molecular and spatial analyses, NNT was identified as a potential prognostic biomarker in obesity-associated CRC. This study highlights the importance of combining clinical data with spatial transcriptomics to uncover context-specific tumor biology.
Sungjin Park
Diabetes, Obesity, and Endometrial Cancer: A Review December 24, 2025
Endometrial cancer is the fourth most diagnosed cancer in U.S. women. Diabetes and obesity are established independent risk factors for EC, but their combined effect is less defined. This review investigates the literature on these comorbidities as risk factors and modifiers of EC. Multiple cohort and case-control investigations have shown an increased relative risk (RR) […]
Olivia Hooks
Familial risk of pancreatic cancer and interaction with hyperglycemia, smoking, and obesity among first-degree relatives December 16, 2025
No abstract
Hyun Jung Kim
The Role of Chinese Medicine as a Complementary Therapy in the Management of Obesity-Associated Colorectal Cancer December 14, 2025
BACKGROUND: Colorectal cancer (CRC) has recently been identified as the world's third commonest cause of cancer death, accounting for 900,000 deaths per year. Obesity-related CRC has also been on the rise, with research indicating that increasing body mass index (BMI) is associated with an increased risk of CRC. As a result, there is a need […]
Chester Yan Jie Ng
Cancer-Associated Cachexia in the Era of Obesity December 11, 2025
Obesity and cancer cachexia represent opposite ends of the body mass index (BMI) spectrum. However, despite this apparent dichotomy, both conditions share critical metabolic alterations, primarily driven by inflammation, metabolic alterations and changes in adipose tissue biology. Obesity is characterised by chronic low-grade inflammation and increased fat storage, while cancer cachexia involves severe weight loss, […]
Joyce Cristina Ferreira de Resende
Associations between obesity and outcomes in pembrolizumab-treated endometrial cancer December 11, 2025
CONCLUSIONS: In this diverse cohort, obesity was associated with worse PFS in patients treated with pembrolizumab for EC. MMRp tumors in obese patients had lowest response rates among subgroups. Further studies with long term follow up are needed to elucidate the biological mechanisms linking obesity to immunotherapy outcomes.
Bryanna Patterson
Unravelling the obesity paradox in cancer: An umbrella review of protective associations and evidence credibility across 13 malignancies December 3, 2025
CONCLUSIONS: Only 21 (14 %) meta-analyses provided convincing or highly suggestive evidence, demonstrating potential associations of obesity in specific oncological contexts pertaining to both reduced incidence risk and improved prognostic outcomes. This synthesis also highlights critical gaps in current evidence, emphasising the need for standardised adiposity metrics, more prudent stratification, and rigorous methodology.
Lulin Yu
Macrophages in obesity-related breast cancer: mechanistic insights and therapeutic opportunities November 28, 2025
Obesity has emerged as a global public health crisis, significantly increasing susceptibility to malignancies, including breast cancer. In the context of Obesity-Related Breast Cancer (ORBC), the abundant adipose tissue in the mammary gland profoundly reshapes the tumor microenvironment (TME). Whereas obesity drives chronic, low-grade inflammation through pro-inflammatory M1 adipose tissue macrophages (ATMs), tumor-associated macrophages (TAMs) […]
Huiyu Dong
Effects of Helicobacter pylori infection on gastric cancer, obesity and esophageal diseases: a systematic review and meta-analysis November 27, 2025
CONCLUSION: H. pylori infection increases the risk of GC, H. pylori eradication is highly important for reducing the risk of GC. H. pylori infection was not associated with reduced risk of obesity and GERD, but the related evidence is limited and the mechanism is not clear. Based on the available evidence, decision-making for eradication treatment […]
Qian Zhou
Obesity as a Catalyst for Endometrial Hyperplasia and Cancer Progression: A Narrative Review of Epidemiology, Molecular Pathways, and Prevention November 27, 2025
Obesity is a major, modifiable driver of endometrial carcinogenesis. This review distills how excess adiposity promotes malignant change and synthesizes prevention strategies across the hyperplasia-cancer continuum. Three converging axes underpin risk: aromatase-mediated estrogen excess; insulin resistance with hyperinsulinemia activating PI3K-AKT-mTOR signaling; and adipokine-driven low-grade inflammation with downstream NF-κB/STAT3 activity. Within this framework, EIN is the […]
Ionela-Mihaela Ordeanu
Obesity Paradox in Cancer: A Complex Interplay Between Risk and Therapeutic Outcomes November 21, 2025
Obesity is a recognized risk factor for cancer development and progression. Paradoxically, growing clinical evidence across several cancer types indicates that elevated body mass index (BMI) or specific body composition characteristics-such as increased visceral fat or preserved skeletal muscle-may be associated with moderately improved overall survival in patients undergoing immune checkpoint inhibitor (ICI) therapy. This […]
Tong Chen
Exploring the biological mechanisms of obesity affecting breast cancer from a multidimensional perspective November 21, 2025
Obesity, a global health challenge, significantly contributes to breast cancer pathogenesis through chronic inflammation and metabolic dysregulation. This review summarizes the biological mechanisms through which obesity influences the development and progression of breast cancer, focusing on endocrine regulation, intercellular communication, gut microbiota interactions, obesity-associated genetic polymorphisms, and circadian rhythm homeostasis. The aim is to provide […]
Yingying Rao
From obesity to cancer: Gut microbiome mechanisms, biomarkers, and U.S. public health strategies November 12, 2025
CONCLUSIONS: The gut microbiome functions as both a biomarker and therapeutic target across metabolic and neoplastic diseases. Integrating microbiome science with environmental epidemiology and MPE frameworks offers transformative potential for precision prevention and equitable public health strategies in the U.S.
Hashim Muhammad Moseeb
Unraveling the genetic links between obesity or insulin resistance and breast cancer through the impact of CD295 and ITLN1 SNPs with DNA damage in a case-controlled study with bioinformatics analysis November 12, 2025
CONCLUSION: CD295 (rs6700986) and ITLN1 (rs952804) SNPs should be considered as BC-associated susceptibility risk factors in obese, insulin resistance, or pre-diabetic individuals.
Nadia M Hamdy
Effect of Obesity on Perioperative Outcomes Following Lung Cancer Surgery: Protocol for a Meta-Analysis and Systematic Review November 12, 2025
CONCLUSIONS: This study will synthesize existing evidence to clarify whether obesity is a risk factor for adverse outcomes or if it confers a protective effect, as suggested by the obesity paradox. These findings will guide clinical decision-making and improve perioperative care for obese people with lung cancer.
Qiuxiang Wang
Weight Loss, Obesity Medication, and Risk of Obesity-Associated Cancer: A Meta-Analysis of Randomized Controlled Trials November 5, 2025
CONCLUSIONS: Weight reduction mediated by current AOMs was not associated with a reduced risk of overall or site-specific obesity-associated cancer in patients with overweight or obesity, while a decreased risk of overall obesity-associated cancer was observed in coagonist users.
Chengwen Li
Overeating: A Conundrum of Lipid Metabolism and Inflammation in Obesity and Cancer October 28, 2025
The global rise in obesity has coincided with an alarming increase in early-onset cancers and other chronic noncommunicable diseases, underscoring the urgent need to understand the underlying mechanisms linking excess body weight with disease pathogenesis. While genetic factors account for disease risk, environmental and dietary influences, particularly those associated with Western hypercaloric diets, play a […]
Aizhan Surumbayeva
Effectiveness of sustained leisure-time physical activity strategies for obesity-related cancer prevention: an emulated target trial in a prospective US cohort October 27, 2025
CONCLUSIONS: We estimated that, compared to no intervention, sustaining MVPA volumes below recommendations may modestly increase obesity-related cancer risk over 11 years, whereas exceeding recommendations may modestly reduce risk, particularly among participants already meeting the recommendations prior to intervention.
Valeria Elahy

Prevalence of Obesity-Associated Cancers in the United States

Cancer Types

Breast	Thyroid	Adenocarcinoma of the esophagus
Colon & Rectum	Liver	Ovary
Kidney	Multiple Myeloma	Gallbladder
Endometrium	Upper Stomach
Pancreas	Meningioma