Cancer & Obesity Reviews (20 of the most recent)
- The effects of obesity on surgical complications and postoperative prognosis of epithelial ovarian cancer: a meta-analysis March 28, 2025OBJECTIVE: To comprehensively evaluate and compare surgical outcomes of obese patients versus non-obese patients for surgical complications and postoperative prognosis due to epithelial ovarian cancer (EOC).Jingjing Sheng
- Obesity and Risk of Pre- and Postmenopausal Breast Cancer in Africa: A Systematic Review March 26, 2025Background and Aims: Several epidemiological studies have investigated the relationship between anthropometric factors and breast cancer (BC), but the results, particularly for premenopausal BC, remain inconsistent and contradictory. The aim of this systematic review is to present an overview of studies examining the association between obesity and BC risk in African women, by menopausal status. […]Najia Mane
- The impact of the tumor microenvironment in the dual burden of obesity-cancer link March 24, 2025Obesity induces systemic perturbations of tissue homeostasis, leading to dyslipidemia, insulin resistance and chronic state of inflammation. Evidence from clinical and preclinical studies links excess of adiposity with increased cancer incidence and suggests that chronic inflammation may contribute to increased cancer risk in obese patients. Over the last decades of obesity research, multifaced and complicated […]Serena Sagliocchi
- A Novel Insight into the Role of Obesity-Related Adipokines in Ovarian Cancer-State-of-the-Art Review and Future Perspectives March 13, 2025Ovarian cancer (OC) is one of the most fatal gynecological neoplasms. Meta-analyses have shown that the relationship between body mass index (BMI) and ovarian cancer incidence was detected in some types of ovarian cancer. Chronic inflammation and excessive accumulation of free fatty acids are key adipose tissue-derived factors initiating cancer development. Cancer cells transform adipose-derived […]Klaudia Kołakowska
- Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link March 5, 2025Obesity, a global health concern, is associated with severe health issues like type 2 diabetes, heart disease, and respiratory complications. It also increases the risk of various cancers, including melanoma, endometrial, prostate, pancreatic, esophageal adenocarcinoma, colorectal carcinoma, renal adenocarcinoma, and pre-and post-menopausal breast cancer. Obesity-induced cellular changes, such as impaired CD8^(+) T cell function, dyslipidemia, […]Alanoud Abdulla
- Targeting obesity, metabolic syndrome, and prostate cancer: GLP-1 agonists as emerging therapeutic agents March 2, 2025Prostate cancer (PCa) is known as the second most common cancer and has one of the highest incidences among male cancers in the United States. In addition, obesity and metabolic syndrome are a rising and continuous issue in the United States, with 41.9% of individuals as obese. The importance of highlighting these figures is the […]Azura Murphy
- Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer February 27, 2025PURPOSEOF REVIEW: Ultra-processed foods (UPFs) are becoming more and more important in daily diets around the world; in some cases, they can account for as much as 60% of daily energy intake. Epidemiological evidence suggests that this shift toward high levels of food processing may be partially responsible for the global obesity epidemic and the […]Ioanna A Anastasiou
- Outcomes of Metabolic and Bariatric Surgery in Populations with Obesity and Their Risk of Developing Colorectal Cancer: Where Do We Stand? An Umbrella Review on Behalf of TROGSS-The Robotic Global Surgical Society February 26, 2025Introduction: Obesity is a chronic disease associated with increased risk for several cancers, including colorectal cancer (CRC), a leading cause of cancer-related mortality. The majority of CRC cases are associated with modifiable risk factors. Metabolic and bariatric surgery (MBS) is a proven, durable, and successful intervention for obesity. This study aimed to evaluate the impact […]Aman Goyal
- Editorial: Obesity and cancer: the possible molecular links February 26, 2025No abstractBiswarup Basu
- Ultra-processed food, obesity, and colon cancer: A systematic review and meta-analysis February 17, 2025CONCLUSION: Consuming ultra-processed foods increases the risk of obesity and colon cancer.Justin Tin
- Defining obesity in the context of cancer: thinking beyond body mass index February 15, 2025Obesity is a condition of excess body fat. Although it has been identified as a risk factor for multiple cancers in part because of its 'metainflammatory' state, it has also been paradoxically associated with improved response to immune checkpoint inhibition. To study obesity, one must first understand how best to define it. In this opinion […]Shuchi Gulati
- Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer January 22, 2025PURPOSE OF REVIEW: The role of the microbiome in prostate cancer is an emerging subject of research interest. Certain lifestyle factors, such as obesity and diet, can also impact the microbiome, which has been implicated in many diseases, such as heart disease and diabetes. However, this link has yet to be explored in detail in […]Shaun Trecarten
- Profiling Sociodemographic Risk Factors and Clinical Outcomes of Women with Endometrial Cancer in Puerto Rico: The Central Role of Obesity and Obstetric Features January 20, 2025CONCLUSIONS: This study defined the clinical-demographic profile of women with EC from Puerto Rico and identified risks factors that are associated with younger or older age at diagnosis.Kimberly D García-Irizarry
- Reductive stress-a common metabolic feature of obesity and cancer January 14, 2025Reductive stress, characterized by rising level of NADH (nicotinamide adenine dinucleotide) for a status of NADH/NAD^(+) ratio elevation, has been reported in obesity and cancer. However, the mechanism and significance of reductive stress remain to be established in obesity. This perspective is prepared to address the issue with new insights published recently. NADH is used […]Man Luo
- Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis January 11, 2025Sarcopenic obesity is a condition in which the coexistence of sarcopenia and obesity may have unfavorable prognostic implications in cancer. This meta-analysis aims to evaluate the effects of sarcopenic obesity on postoperative outcomes in patients undergoing colorectal cancer surgery. A systematic literature search was conducted in the Scopus, PubMed, and Web of Science databases for […]Tuba Nur Yıldız Kopuz
- Obesity, Physical Activity, and Cancer Incidence in Two Geographically Distinct Populations; The Gulf Cooperation Council Countries and the United Kingdom-A Systematic Review and Meta-Analysis January 8, 2025CONCLUSION: Although both regions share similarities, advanced healthcare systems, genetic characteristics, dietary habits, and cultural practices may influence cancer incidence and types.Christine Gaskell
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity January 7, 2025Colorectal cancer (CRC) is the third most common cancer worldwide and has one of the highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation and development, with obesity at the forefront. Obesity is regarded as one of the key environmental risk determinants for the pathogenesis of CRC. Excessive food […]Mikołaj Domagalski
- Dietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation December 30, 2024Dietary fiber, found in plant-based foods, plays an essential role in human health. It is divided into two types-soluble and insoluble-both offering significant health benefits. Research has shown that increasing fiber intake can reduce the risk of various chronic diseases, such as cardiovascular diseases (CVD), type II diabetes, obesity, colon cancer, and inflammation. These health […]Layla A Alahmari
- Impact of sarcopenic obesity on postoperative outcomes in patients with oesophago-gastric cancer: A systematic review and meta-analysis December 26, 2024CONCLUSIONS: Sarcopenic obesity worsens OS and increases the risk of postoperative complications in patients with oesophago-gastric cancer undergoing radical resection.Ryota Matsui
- Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review December 18, 2024The progressive globalization of sedentary lifestyles and diets rich in lipids and processed foods has caused two major public health hazards-diabetes and obesity. The strong interlink between obesity and type 2 diabetes mellitus and their combined burden encompass them into a single term 'Diabesity'. They have also been tagged as the drivers for the onset […]Shrikirti Anand