Related Cancers

Cancer & Obesity Reviews (20 of the most recent)

• A Review Article: The Relationship Between Obesity and Colorectal Cancer December 2, 2024
  PURPOSE OF REVIEW: This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.
  Lily Nguyen
• Systematic review: The gut microbiota as a link between colorectal cancer and obesity November 30, 2024
  Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and […]
  Antonio Jesús Ruiz-Malagón
• Explanation of the obesity paradox of immunotherapy in cancer patients using CT-derived adipose composition parameters: A systematic review and meta-analysis November 30, 2024
  CONCLUSION: CT-derived adipose composition parameters such as SFA, SFI and VFI are predictive of clinical outcomes in cancer patients treated with ICIs. Prospective cohorts with larger samples are needed to validate this hypothesis-generating data in the future.
  Jie Lou
• The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity November 25, 2024
  Obesity is a risk factor for developing breast cancer, and significantly increases mortality rates in patients diagnosed with this disease. Drivers of this unfortunate relationships are multifactorial, with obesity-induced changes in the epigenetic state of breast cancer cells being identified as a critical mechanism that impact survival, metastasis, and therapeutic responses. Recent studies have investigated […]
  Ashley Townsel
• Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications November 14, 2024
  Existing epidemiologic and clinical studies have demonstrated that obesity is associated with the risk of a variety of cancers. In recent years, an increasing number of experimental and clinical studies have unraveled the complex relationship between obesity and cancer risk and the underlying mechanisms. Obesity-induced abnormalities in immunity and biochemical metabolism, including chronic inflammation, hormonal […]
  Xiaoye Shi
• Research progress on the correlation between obesity and the occurrence and development of kidney cancer: a narrative review November 11, 2024
  CONCLUSIONS: Epidemiology shows that the high rates of kidney cancer and obesity coincide in terms of region and ethnicity. The underlying mechanisms associated with obesity in promoting the occurrence and development of kidney cancer mainly include: abnormal expression of adipocytokines, abnormal lipid metabolism, abnormalities in the insulin-like growth factor-I (IGF-I) axis and hyperinsulinemia/insulin resistance, hypoxia […]
  Le Kang
• Obesity and lack of breastfeeding: a perfect storm to augment risk of breast cancer? November 11, 2024
  Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with higher rates of recurrence and distant metastasis, as well as decreased 5-year survival rates. Racial disparities are evident in the incidence and mortality rates of triple negative breast cancer particularly increased in young African American women. Concurrently, young African American […]
  Kate Ormiston
• Lung cancer and obesity: A contentious relationship (Review) November 5, 2024
  The global obesity epidemic, attributed to sedentary lifestyles, unhealthy diets, genetics and environmental factors, has led to over 1.9 billion adults being classified as overweight and 650 million living with obesity. Despite advancements in early detection and treatment, lung cancer prognosis remains poor due to late diagnoses and limited therapies. The obesity paradox challenges conventional […]
  Vasiliki Epameinondas Georgakopoulou
• Obesity, white adipose tissue and cancer November 4, 2024
  White adipose tissue (WAT) is crucial for whole-body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet the body's requirements, dysfunctional WAT in conditions like obesity is characterized by excessive tissue expansion, alterations in lipid homeostasis, inflammation, hypoxia, and fibrosis. Obesity is […]
  Estel Solsona-Vilarrasa
• Obesity and leptin in breast cancer angiogenesis October 23, 2024
  At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is […]
  Courtney B Lagarde
• Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence October 23, 2024
  CONCLUSION: This systematic review highlights the complex relationship between metabolic obesity phenotypes and thyroid cancer risk. The findings highlighted the importance of considering metabolic status alongside obesity in thyroid cancer risk assessment and intervention strategies.
  Mehdi Hedayati
• Prevalence of sarcopenic obesity in patients with gastric cancer and effects on adverse outcomes: A meta-analysis and systematic review October 22, 2024
  CONCLUSIONS: The prevalence of sarcopenic obesity is high in patients with gastric cancer and is strongly associated with poor postoperative outcomes. Healthcare providers should evaluate patients with gastric cancer for sarcopenic obesity early to prevent or reduce the incidence of adverse outcomes.
  Bingyan Zhao
• Mechanisms by Which Pharmacotherapy May Impact Cancer Risk among Individuals with Overweight and Obesity October 16, 2024
  Diets geared to reduce cancer risk in overweight and obese individuals focus on (1) caloric restriction (every day, some days, or most hours of each day); (2) changes in macronutrient intake; or (3) a combination of the prior two strategies. Diets generally fail because of nonadherence or due to limited sustained weight loss. This is […]
  Edward R Sauter
• Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin October 16, 2024
  Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An understanding of these mechanisms is pivotal for unraveling pathways relevant to obesity-associated EC, […]
  Takahiko Sakaue
• The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer October 10, 2024
  Dietary fibres constitute a heterogeneous class of nutrients that are key in the prevention of various chronic diseases. Most dietary fibres are fermented by the gut microbiome and may, thereby, modulate the gut microbial ecology and metabolism, impacting human health. Dietary fibres may influence the occurrence of specific bacterial taxa, with this effect varying between […]
  Nathalie M Delzenne
• Anti-oxidative activity of probiotics; focused on cardiovascular disease, cancer, aging, and obesity October 9, 2024
  By disturbing the prooxidant-antioxidant balance in the cell, a condition called oxidative stress is created, causing severe damage to the nucleic acid, protein, and lipid of the host cell, and as a result, endangers the viability of the host cell. A relationship between oxidative stress and several different diseases such as cardiovascular diseases, cancer, and […]
  Batoul Kavyani
• Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk October 8, 2024
  The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to […]
  Zoltan Ungvari
• Body mass index, obesity and risk of prostate cancer: a systematic review and meta-analysis September 30, 2024
  CONCLUSIONS: BMI >25 kg/m² was associated with an increased risk of prostate cancer and mortality.
  Fajar Gemilang Ramadani
• Advancements in Understanding and Preventing Obesity-Related Colon Cancer September 23, 2024
  Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and […]
  Christine Shieh
• The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies September 23, 2024
  Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct malignancies, with excessive visceral adiposity being an increasingly prevalent feature in patients with cancer presenting for therapeutic intervention. Clinical trials and meta-analyses have helped to inform effective and safe dosing of traditional systemically administered anticancer agents in adult patients with […]
  Joanne Lysaght