25 drugs ranked by 2024 healthcare expenditure

In 2024, the U.S. healthcare industry spent $6.1 billion on Pfizer’s COVID-19 therapy Paxlovid, a 6,922.8% increase from 2023 expenditure data, according to a recent study.  The research, published April 23 in the American Journal of Health-System Pharmacy, reviewed the IQVIA National Sales Perspectives database, which tracks medication purchases by hospitals, clinics, retail pharmacies, mail-order … Read more

GLP-1-based therapies for diabetes, obesity and beyond

Nature Reviews Drug Discovery, Published online: 25 April 2025; doi:10.1038/s41573-025-01183-8 GLP-1-based therapies represent highly effective treatments for patients with type 2 diabetes and obesity. This Review profiles established and emerging GLP-1-based medicines, focusing on novel GLP-1 receptor agonists and GLP-1-based multi-agonists. Considerations and challenges in the development of GLP-1-based therapies and potential future indications are … Read more

GLP-1 drugs are proving immune from prescription skepticism

While some Americans might feel doubtful about prescriptions, others are doing all they can to acquire GLP-1 drugs. Carly Johnson of Momentum Worldwide says the results of a new survey show just how popular they are. If you spend even a little bit of time online, you’ve probably seen the social discourse around prescription medications … Read more

Urgent caution over new ‘Ozempic’ side effect as scientists fear ‘tragic wave of people dying to lose weight’

BLOCKBUSTER ‘Ozempic-style’ fat jabs could increase the risk of depression and suicidal thoughts, experts have warned. The injections have allegedly helped celebs like Sun columnist Jeremy Clarkson, Sharon Osbourne and ex-Prime Minister Boris Johnson to shed some pounds. GettyScientists think fat jabs upset dopamine levels in the brain and raise the risk of depression, anxiety, and suicidal thoughts[/caption] Since … Read more

Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials

BACKGROUND Glucagon-like peptide 1 receptor agonists (GLP-1RA) reduce the incidence of major adverse cardiovascular events (MACE) in type 2 diabetes (T2D), although whether benefits extend to both subcutaneous and oral formulations remains unclear. PURPOSE In these meta-analyses, including new data from the Semaglutide cardiOvascular oUtcomes triaL (SOUL) (oral semaglutide) and Evaluate Renal Function with Semaglutide … Read more