Obesity Genetics - Genetic Reviews, Recent Papers, and Clinical Trials

RSS REVIEWS from PubMed – December 27, 2023 – Obesity (in title) AND Cancer (in title) AND Genetics (in title) AND Review
  • A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics June 2, 2021
    There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific […]
    Matteo Lazzeroni
  • Endometrial Cancer: Obesity, Genetics, and Targeted Agents January 27, 2019
    It is imperative to understand the underlying mechanisms of both endometrial carcinogenesis and recurrence in order to develop more effective prevention and treatment. This article reviews available molecular data, the interplay between endometrial cancer carcinogenesis with obesity and genetics, as well as current targeted therapies.
    Megan E McDonald
RSS RECENT PAPERS from PubMed – December 27, 2023 – Obesity (in title) AND Cancer (in title) AND Genetics (in title)
  • A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics June 2, 2021
    There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We meta-analyzed studies reporting on obesity and colorectal cancer (CRC) risk in LS patients to test whether obese subjects were at increased risk of cancer compared to those of normal weight. We explored also a possible sex-specific […]
    Matteo Lazzeroni
  • Endometrial Cancer: Obesity, Genetics, and Targeted Agents January 27, 2019
    It is imperative to understand the underlying mechanisms of both endometrial carcinogenesis and recurrence in order to develop more effective prevention and treatment. This article reviews available molecular data, the interplay between endometrial cancer carcinogenesis with obesity and genetics, as well as current targeted therapies.
    Megan E McDonald
  • The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention September 27, 2012
    Recent studies demonstrated that obesity is associated with prostate cancer aggressiveness and prognosis. However, the mechanisms underlying this relationship are poorly understood. Tumor microenvironment has been increasingly considered as an important determinant of cancer growth and progression. In the light of this growing evidence, Ribeiro et al., in a BMC Medicine research article, investigated the […]
    Giovanni Lughezzani
  • Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study October 7, 2011
    Obesity is a well-established risk factor for endometrial cancer, the most common gynecologic malignancy. Recent genome-wide association studies (GWAS) have identified multiple genetic markers for obesity. The authors evaluated the association of obesity-related single nucleotide polymorphisms (SNPs) with endometrial cancer using GWAS data from their recently completed study, the Shanghai Endometrial Cancer Genetics Study, which […]
    Ryan J Delahanty

US Clinical Trials involving Genetics and Obesity

NCT NumberStudy TitleStudy URLStudy StatusConditionsInterventionsSponsorCollaboratorsStudy Type
NCT02143830HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapyhttps://clinicaltrials.gov/study/NCT02143830RECRUITINGFanconi Anemia|Severe Marrow Failure|Myelodysplastic Syndrome (MDS)|Acute Myelogenous Leukemia (AML)DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: rabbit ATG|DRUG: G-CSF|BIOLOGICAL: Peripheral blood stem cellChildren's Hospital Medical Center, CincinnatiMemorial Sloan Kettering Cancer Center|Fred Hutchinson Cancer CenterINTERVENTIONAL
NCT01313455Adrenal Hyperplasia Among Young People With PCOShttps://clinicaltrials.gov/study/NCT01313455COMPLETEDAdrenal Hyperplasia|Polycystic Ovarian Syndrome|Oligomenorrhea|Obesity|HyperandrogenismEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)OBSERVATIONAL
NCT01443156The Effects of Work Schedule and Sleep Patterns on Caregivers' Healthhttps://clinicaltrials.gov/study/NCT01443156COMPLETEDObesity|Diabetes|Cancer|Metabolic Syndrome|Sleep DeprivationOregon Health and Science UniversityOBSERVATIONAL
NCT00758108Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletionshttps://clinicaltrials.gov/study/NCT00758108COMPLETEDWAGR Syndrome|Wilm's Tumor|Aniridia|Urogenital Abnormalities|Mental RetardationEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)OBSERVATIONAL
NCT03600909A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemiahttps://clinicaltrials.gov/study/NCT03600909TERMINATEDFanconi Anemia|Myelodysplastic Syndrome (MDS)|Acute Myelogenous Leukemia (AML)DRUG: Busulfan|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Anti-Thymocyte Globulin (Rabbit)|DEVICE: The CliniMACS device|DRUG: G-CSFMemorial Sloan Kettering Cancer CenterPediatric Brain Tumor ConsortiumINTERVENTIONAL
NCT05963971A Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factorshttps://clinicaltrials.gov/study/NCT05963971RECRUITINGAcute Lymphoblastic Leukemia|ObesityBEHAVIORAL: PEDALL|OTHER: Standard of careColumbia UniversityINTERVENTIONAL
NCT01870947Assisted Exercise in Obese Endometrial Cancer Patientshttps://clinicaltrials.gov/study/NCT01870947COMPLETEDStage I Endometrial Adenocarcinoma|Uterine Cancer|ObesityBEHAVIORAL: Exercise on stationary recumbent exercise cycle|BEHAVIORAL: Health Education|BEHAVIORAL: Questionnaires|PROCEDURE: Neuroimaging|PROCEDURE: Genetic and BiomarkersCase Comprehensive Cancer CenterINTERVENTIONAL
NCT05687188Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populationshttps://clinicaltrials.gov/study/NCT05687188ACTIVE_NOT_RECRUITINGPancreatic CancerOTHER: Blood Sample Collection|OTHER: Tissue Sample Collection|OTHER: Data Collection|OTHER: Medical Image CollectionH. Lee Moffitt Cancer Center and Research InstituteUnited States Department of DefenseOBSERVATIONAL
NCT01647776Screening and Risk Factors of Colon Neoplasiahttps://clinicaltrials.gov/study/NCT01647776COMPLETEDColon CancerOTHER: Stool DNA Test|PROCEDURE: biopsies of rectal and colon mucosa|OTHER: QuestionnairesCase Comprehensive Cancer CenterOBSERVATIONAL
NCT02015078Black Family Eating Behaviors Studyhttps://clinicaltrials.gov/study/NCT02015078COMPLETEDCancer|ObesityNational Human Genome Research Institute (NHGRI)Duke University|National Cancer Institute (NCI)|University of North CarolinaOBSERVATIONAL
NCT05732623Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancerhttps://clinicaltrials.gov/study/NCT05732623RECRUITINGColorectal Cancer|Early Onset Colorectal Cancer|Diet Habit|Risk ReductionBEHAVIORAL: Semi Quantitative Food Frequency Questionnaire (SQFFQ)San Raffaele UniversityFondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy|Ospedale Civile Guglielmo da Saliceto, Piacenza, Italy|Centro di Riferimento Oncologico di Aviano, Aviano, Italy|Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy|Gastroenterology Unit, University Hospital of Padova, Padova, Italy|Clinical Gastroenterology Unit, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy|IRCCS Arcispedale S. Maria Nuova - Azienda Ospedaliera di Reggio Emilia, Reggio Emilia, Italy|Azienda Ospedaliera San Gerardo di Monza, Monza, Italy|Azienda ULSS5 Polesana, Rovigo, Italy|Istituto Tumori Regina Elena - IRCCS IFO, Roma, Italy|University Hospital of Padova, Padova, Italy|IRCCS De Bellis, Castellana Grotte, Italy|University Hospital HELIOS Klinikum Wuppertal, Center for Hereditary Tumors, University of Witten-Herdecke, Wuppertal, Germany|Hospital of the University of Munich (LMU), Campus Großhadern, Munich, Germany|Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain|Helsinki University Hospital, Helsinki, Finland|Oslo University Hospital (OUS), Institute for Cancer Genetics and Informatics Norwegian Radium Hospital, Oslo, Norway|Department of Medicine University of Chicago Medicine, Illinois, USA|University of Colorado Hospital, CO, USA|University of Michigan Ann Arbor, Michigan, USA|Columbia University Irving Medical Center, New York, NY|The James Comprehensive Cancer Center, Columbus, OH, USA|Ohio State University|Cleveland Clinic Main Campus, Cleveland, OH, USA|Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, AustraliaOBSERVATIONAL