This systematic review and meta-analysis investigated the rate of weight regain after people stopped using GLP-1 receptor agonists (GLP-1 RAs) for weight management. The researchers identified relevant studies and analyzed the weight loss achieved during treatment and the subsequent weight increase once medication stopped. Their findings indicate that participants regain a significant amount of weight relatively quickly after discontinuing GLP-1 RAs, with weight potentially returning to baseline within two years. The study concludes that relying solely on these medications without a broader strategy for obesity treatment and weight maintenance may lead to rapid weight regain.
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