Scientific paper explores the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1RAs) for Alzheimer’s disease (AD), building on the known link between type 2 diabetes and increased AD risk. The research indicates that GLP-1 levels are lower in AD, correlating negatively with amyloid-beta (Aβ) levels in patients. Through experiments in transgenic mice and cell lines, the authors demonstrate that GLP-1RAs can activate AMPK signaling, which in turn reduces Aβ production by regulating BACE1 and enhances microglial clearance of Aβ. These findings suggest that targeting AMPK activation with GLP-1RAs could be a viable treatment strategy for AD, leading to reduced plaque formation and improved cognitive function.
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