

Rare sugars curb appetite and mimic diabetes drugs in mice
Rare sugars like D-allulose, D-tagatose, and D-sorbose significantly boosted GLP-1 secretion and suppressed food intake in mice. D-allose also reduced food intake through a unique, GLP-1-independent pathway.

HIMS Expands Telehealth Offerings with Eli Lilly’s GLP-1 Drugs
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GLP-1 spending hits $5.8B for adults without diabetes
A new study found that spending on GLP-1 medications such as Ozempic, Wegovy and Zepbound surged to $5.8 billion in 2022 among U.S. adults without diabetes. The research, published April
Eli Lilly sues Empower, Strive over tirzepatide products
Eli Lilly has sued two large compounding pharmacies, alleging they deceive patients and put them at risk with compounded versions of the obesity drug tirzepatide in combinations or forms that
I dropped 4 stone on fat jabs – people say it’s the ‘best glow-up’ they’ve seen but I had a very unexpected side effect
A 29-YEAR-OLD has revealed that she lost over four stone after using Mounjaro for six months. Jasmine Hannah, a woman from the UK, confirmed that she once topped the scales
Here’s how much Ozempic and similar drugs have soared in popularity since 2018
The use of GLP-1 meds — made popular by Ozempic (NVO) — among U.S. adults without diabetes more than tripled between 2018 and 2022, with annual spending surging from $1.6
FDA Approves Semaglutide to Reduce Risk of Kidney Disease Progression
Semaglutide, marketed as Ozempic, recently became the first glucagon-like peptide 1 (GLP-1) receptor agonist approved by the US Food and Drug Administration (FDA) to reduce the risk of worsening kidney
Labor Smart Targets GLP-1 Market with Functional Gummies – Pre-Orders Begin April 7th
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Costly GLP-1 drug use for weight loss has soared, study reports
The number of Americans taking cutting-edge weight-loss drugs like Ozempic, Wegovy and Zepbound has skyrocketed in recent years, a new study says.
Largest single-cell map of the aging brain reveals vulnerable cell types and regions
A new study published in Nature offers the most detailed map to date of how individual cell types in the brain change with age. Scientists analyzed over 1.2 million brain
The brutal Ozempic side effects celebs have been blighted by & those they WON’T admit to, from trout pouts to vomiting
[/boxout] Vomiting Both Stephen Fry and Boris Johnson have admitted to vomiting while trying to shed weight with the jabs. Stephen Fry was left vomiting five times a day while
GLP-1 Drug Use For Weight Loss Has Soared, Costing Billions
By Dennis Thompson HealthDay ReporterTUESDAY, April 1, 2025 (HealthDay News) — The number of Americans taking cutting-edge weight-loss drugs like…
Where Will Eli Lilly Be in 1 Year?
Pharmaceutical powerhouse Eli Lilly (NYSE: LLY) had a banner year in 2024. The company’s sales surged 32% to over $45 billion on massive growth from its GLP-1 agonist products, Mounjaro
Nurse reveals what you MUST drink if you are on GLP-1 meds like Ozempic and Mounjaro
A nurse has revealed exactly what you need to be drinking when you’re on a GLP-1 medication – and why hydration on the medication is so important.
GLP-1 Receptor Agonists in Pediatric and Adolescent Obesity
Obesity remains highly prevalent among children in the United States and is associated with an ever-increasing burden of obesity-related diseases. Effective pediatric obesity prevention and treatment will require both societal
Noom Partners with LillyDirect to Streamline Access to Zepbound® for Weight Management
What You Should Know: – Noom, a digital healthcare company focused on chronic disease prevention and empowering healthy living announced an agreement with Gifthealth, the LillyDirect® pharmacy provider of Eli
GLP-1 Spending Hit $5.8 Billion in 2022 for U.S. Adults Without Diabetes
(MedPage Today) — The number of U.S. adults without diabetes using GLP-1 receptor agonists more than tripled from 2018 to 2022, boosting annual spending from $1.6 billion to $5.8 billion,
Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study
Background: Obesity is a global public health challenge. Pharmacological interventions, such as glucagon-like peptide-1 (GLP-1) receptor agonists (eg, semaglutide) and dual GLP-1/gastric inhibitory polypeptide receptor agonists (eg, tirzepatide), have led
Semaglutide boosts walking ability in diabetes patients with peripheral artery disease, clinical trial finds
Semaglutide, a glucagon-like peptide 1 (GLP-1) agonist, significantly improved maximal walking distance in people with symptomatic peripheral artery disease (PAD) and type 2 diabetes in the first-of-its kind trial to
Novo Nordisk’s Monthly Share Plunge Largest Since Dot Com Bust
Novo Nordisk’s Monthly Share Plunge Largest Since Dot Com Bust Novo Nordisk A/S shares are on track for their steepest monthly decline since the Dot-Com bust as setbacks pile up
Bariatric surgery’s next act: What 3 leaders expect
GLP-1 medications are reshaping the weight management landscape — and beginning to take a bite out of bariatric surgery volumes in hospitals. Between 2022 and 2023, bariatric surgery rates fell
DXCM Inks Deal With Nanowear to Boost CGM Application Beyond Diabetes
DexCom DXCM recently signed a licensing and data partnership with a privately held healthcare-at-home digital diagnostics company — Nanowear. Per the terms of the agreement, Nanowear will use glucose data
Elenzia launches science-backed GLP-1 booster
UK-based wellness brand Elénzia is expanding its supplement portfolio with a new product for appetite control and blood sugar regulation.
FDA reviews Novo Nordisk’s bid to expand Rybelsus as oral GLP-1 cuts heart disease risks
The FDA has accepted Novo Nordisk’s application for a label expansion for oral GLP-1 treatment Rybelsus to reduce the risk of major adverse cardiovascular events (MACE) in adults with type
ENDRA Life Sciences Announces Enhanced Strategy to Enable the Early Detection and Management of Metabolic Diseases Facilitated by Emerging GLP-1 Therapies
ANN ARBOR, Mich.–(BUSINESS WIRE)–ENDRA Life Sciences Inc. (NASDAQ: NDRA), a pioneer of Thermo-Acoustic Enhanced UltraSound (TAEUS®), today announced a new strategic direction to develop and deploy its TAEUS system as
Stud reveals more type 1 diabetics are obese, taking GLP-1 drugs
Use of cutting-edge weight-loss drugs like Ozempic and Zepbound has increased dramatically among people with type 1 diabetes, raising safety concerns among experts, a new study says.
Danone’s CMO on adapting advertising as GLP-1 upends the food industry
Linda Bethea details how the marketer of brands including Oikos and Silk is approaching emerging channels and artificial intelligence.
Palatin Announces MC4R Agonist Bremelanotide Co-Administered with GLP-1/GIP Tirzepatide Meets …
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The Vitamin Shoppe launches GLP-1 support supplement range
How the health and wellness boom is fueling Hain Celestial’s transformation
CEO Wendy Davidson said the Sleepytime Tea maker needed to first stabilize its business and boost innovation before it could tap into movements such as GLP-1 use.
GLP-1 and glucagon receptor dual agonism ameliorates kidney allograft fibrosis by improving lipid metabolism
IntroductionKidney allograft fibrosis accelerates the progression of chronic kidney disease (CKD), leads to allograft failure, and increases patient mortality. Emerging evidence suggests that metabolic syndrome in transplant recipients is associated
Hims Is Begging Customers to Lobby the FDA to Keep Its Ozempic Knockoffs Legal
You know Hims, right? It’s the next-gen telehealth startup famous for taking the eye contact out of erectile dysfunction treatment. Of course, bedroom pills aren’t all Hims peddles. The Uberized men’s
Oral GLP-1 Receptor Antagonist Reduces CV Risk
Oral semaglutide, already approved for type 2 diabetes, led to a reduction in CV events in patients with established atherosclerotic disease, CKD, or both. Medscape Medical News
Semaglutide improves maximal walking distance in people with symptomatic PAD and Type 2 diabetes
Semaglutide, a glucagon-like peptide 1 (GLP-1) agonist, significantly improved maximal walking distance in people with symptomatic peripheral artery disease (PAD) and Type 2 diabetes in the first-of-its kind trial to
Semaglutide Shows Major Benefits in PAD: STRIDE
The GLP-1 agonist has shown convincing benefits in yet another population, patients with peripheral arterial disease, in a practice-changing trial, according to experts. Medscape Medical News
Will Using Semaglutide Increase Your Risk of Thyroid Cancer?
New research shows GLP1-RA medications do not increase thyroid cancer risk, reassuring users and clinicians. A new study, published in the peer-reviewed journal Thyroid, the official journal of the American
I lost 10 and a half stone on Mounjaro – people said I’d ‘always be a bigger girl’ but it’s totally changed my life
A MOTHER has revealed that she has lost 10 and a half stone after using Mounjaro. Becca Banks, a mum-of-one from the UK, confirmed that she once topped the scales
Most Older Adults Say Medicare And Other Insurance Should Cover Obesity Drugs
A large majority of older Americans feel that health insurance – including Medicare – should cover anti-obesity medications, according to a new University of Michigan study. And more than half
Conagra Brands, Inc. (CAG): Jim Cramer’s Frozen Food Aisle Is Buzzing Again
We recently published a list of Was Jim Cramer’s Call Right on These 10 Stocks? In this article, we are going to take a look at where Conagra Brands, Inc.
Novo Nordisk’s diabetes pill slashes risk of cardiovascular complications by 14% after four years – CNBC
Novo Nordisk’s diabetes pill slashes risk of cardiovascular complications by 14% after four years CNBC Semaglutide, or Ozempic, reduces symptoms of feared diabetes’ complication, study finds The Globe and Mail Ozempic® (once-weekly
Dr. McCullough Weighs In: The History & Future of GLP-1s
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I was on fat jabs for 2 years & dropped over 8 stone – people said I would regret it & now trolls say I look ‘two thin’
A MOTHER has revealed that she lost over eight stone after using fat jabs for two years. Bridget claimed that everyone said she would regret using the weight loss injections,
Viemed Healthcare, Inc. (VMD): A Bull Case Theory
We came across a bullish thesis on Viemed Healthcare, Inc. (VMD) on Substack by Petty Cash. In this article, we will summarize the bulls’ thesis on VMD. Viemed Healthcare, Inc. (VMD)’s share
Medifast: GLP-1 Caused A Vicious MLM Flywheel Effect
GLP-1 Drugs Effectiveness Reduced by Neurons That Control Overeating
Understanding the role of the brain in hedonic eating—the act of eating for pleasure rather than for physiological need—has been a popular endeavor. Researchers at the University of California, San
Novo inks $1B biobucks Lexicon obesity deal after seeing preclinical prospect shine with semaglutide
Lexicon Pharmaceuticals’ pursuit of the last word in obesity candidates has attracted Novo Nordisk. The Danish drugmaker is betting $75 million in upfront and near-term milestone payments to secure global
Semaglutide Use Linked to Risk for Vision Loss in Diabetes
Patients with diabetes who take semaglutide are at increased risk for NAION compared with patients who do not use GLP-1 RAs to control their blood sugar, a new study finds.
Two‐pronged approach: Therapeutic effect of biological scaffold combined with immune intervention and β‐cell replacement on type 1 diabetic mice
Abstract Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by β-cell damage and absolute insulin deficiency. We consider combining immune intervention and β-cell replacement by biological scaffold
Defective lymphatic vasculature in obesity
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet-induced obesity animal models have indicated
Collective Health, Noom Health partner for weight management
The partnership will give customers easy access to GLP-1 class drugs and other anti-obesity medications.
Senate Republican questions FDA chief on counterfeit weight loss drugs
Sen. Jim Banks (R-Ind.) wants the Food and Drug Administration to look into foreign-made active pharmaceutical ingredients he says are being included online weight loss drugs. In a letter to
Coaching Boosts GLP-1 Effectiveness in Managing Weight Loss
Regaining weight after discontinuing GLP-1s is common, but ongoing coaching can help support patients to maintain their weight loss. Medscape Diabetes & Endocrinology
New Frontiers at ACC Meeting: Semaglutide, INOCA, & More
(MedPage Today) — CHICAGO — Coming this weekend, the American College of Cardiology (ACC) annual conference will feature research exploring new frontiers for GLP-1 drugs in cardiovascular medicine, and foundational
VKTX Finishes Enrolment in Mid-Stage Study on Oral Weight-Loss Drug
Viking Therapeutics VKTX announced that it has completed enrolling study participants in the phase II VENTURE-Oral Dosing study, which is evaluating the safety and efficacy of the oral formulation of
Beyond GLP-1 Drugs: This Opportunity at Eli Lilly Could Surprise Everyone in 2025
Over the last couple of years, the pharmaceutical sector has captivated investors thanks in large part to novel medications used to treat chronic weight management and diabetes. While you may
Ozempic Will Soon Be a Thing of the Past: Meet the Next Generation of Weight Loss Drugs
Many pharmaceutical companies and laboratories have been working for months to replicate the success of drugs such as Ozempic, Wegovy, and Zepbound. These medications are based on compounds originally developed
Makary’s FDA Has Options In Industry Fight Over Weight Loss Drugs
Americans pay far more for GLP-1 drugs than citizens in other wealthy countries. If Dr. Makary, the new FDA Commissioner, wants to change this, he has several options.
AI-Driven Efficient De Novo design of GLP-1RAs with Extended Half-Life and Enhanced Efficacy
Peptide drug has revolutionized modern therapeutics, offering novel treatment avenues for various diseases. However, low efficacy, time consumption, and high cost hinder peptide drug design and discovery. We present an
Report: Traditional Drug Costs Outpace Specialty Due to GLP-1 Demand
The annual growth rate of spending for traditional drugs increased from 2.1% in 2021 to 12.8% in 2024, according to Evernorth Research Institute. The post Report: Traditional Drug Costs Outpace
GLP-1 drugs are only the start – the powerful drugs to expect next
The race is under way to make faster, cheaper and better GLP-1 drugs that will go beyond reducing obesity levels to treating some of our most difficult conditions
Cheaper and More Effective: New MIT Breakthrough Could Improve Popular Weight Loss Drugs Such As Ozempic
MIT scientists have created a method to “paint” GLP-1 drugs onto antibodies inside the body, achieving longer-lasting effects with smaller doses. Glucagon-like peptide-1 (GLP-1) receptor agonists are peptide-based drugs used
Mice Lose Interest in High-Fat Diet Due to Declining Neurotensin
The pleasure we get from eating junk food—the dopamine rush—is often blamed as the cause of overeating and rising obesity rates in our society. But paradoxically, anecdotal evidence suggests that
6 GLP-1 updates
Four blockbuster GLP-1 medications are expected to be among the 10 best-selling drugs in 2026, accounting for $66.8 billion in global sales, according to market research company Statista Statista predicts
Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation
The Notch signaling pathway is crucial for germline stem cell (GSC) regulation in C. elegans, yet the molecular and biological consequences of GLP-1/Notch mutations remain poorly understood. This study systematically
Affirm Expands Market Reach With J.P. Morgan Payments and FuturHealth
Affirm Holdings, Inc. AFRM is expanding its payment solutions with two major partnerships: one with JPMorgan Chase & Co. JPM Payments and a new integration with FuturHealth. These collaborations will
Why exercise is more important than ever when taking weight-loss drugs
GLP-1 drugs have revolutionised the treatment of obesity, but the very reason they are effective is also why it’s vital to prioritise exercise when taking them
Collective Health, Noom Health Offer Integrated GLP-1 Weight Management Solution
What You Should Know: – Collective Health, a leader in employee health benefits, and Noom Health, the enterprise division of digital healthcare leader Noom announced a partnership to deliver Collective
Microdosing GLP-1 drugs is on the rise – but does it work?
There are many claims about the benefits of microdosing weight-loss drugs, from anti-inflammatory effects to extending longevity. Do any of them stack up?
What do GLP-1 drugs really tell us about the brain’s reward system?
Anecdotal reports suggest drugs like Ozempic may curb not just appetite but also impulsive or addictive behaviour, hinting at links between metabolic health and our brains
Study links Wegovy to increased hair loss risk
A new study from the University of British Columbia says an ingredient used in popular weight loss drugs could have side effects linked to hair loss. Semaglutide, the main ingredient
Which Side Will Makary Take In The Fight Over Weight Loss Drugs?
Billions of dollars in annual revenue and the health of millions of patients are at stake in a drug industry battle over who can make and sell GLP-1 weight loss
The United Laboratories and Novo Nordisk Announce Exclusive License Agreement for UBT251, a GLP-1/GIP/Glucagon Triple Receptor Agonist
Guangdong, China and Bagsværd, Denmark, 24 March 2025 –The United Laboratories International Holdings Limited (TUL) and Novo Nordisk A/S (Novo Nordisk) today announced that Novo Nordisk and TUL’s wholly-owned subsidiary
Report shows increased pharma innovation despite rising R&D costs
The obesity market is driving pharma’s return on investment (ROI) upward, with the projected return rising to 5.9% overall in 2024, but only reaching 3.8% if GLP-1 assets are excluded.
Starving Cancer Cells Where They Live
I’ve been meaning to write about this paper, although it’s not exactly medicinal chemistry (!) But it is a really novel – and rather daring – approach to cancer treatment,
I lost half my weight on fat jabs – being skinny is great but ‘Ozempic butt’ is a real side effect
A WOMAN has revealed the bizarre side effect of taking fat loss injections. Amy Kane lost 11 stone with the weight loss drug and is thrilled with the results. @amyinhalfAmy
Affirm + FuturHealth Partner to Make GLP-1 Medications More Accessible with Flexible Payment Options
What You Should Know: – FuturHealth, a provider of personalized weight-loss solutions partners with Affirm, the payment network that empowers consumers and helps merchants drive growth. – The collaboration will
Pharma R&D Returns Surge in 2024, Driven by GLP-1 Therapies, Despite Rising Costs
What You Should Know: – The pharmaceutical research and development (R&D) sector is experiencing a significant upswing, with projected returns on investment climbing to 5.9% in 2024, according to a
Study Identifies Benefits and Risks of GLP-1 Drugs Across 175 Health Outcomes
A recent study published in Nature Medicine may provide valuable insights into the previously unreported benefits and risks of glucagon-like peptide-1 (GLP-1) receptor agonist use on a set of 175
Are “copycat” compounded weight loss drugs safe?
In the UK more than 3 in every 1000 people are taking glucagon-like peptide-1 (GLP-1) agonist drugs, says Kevin McCarroll, consultant physician and geriatrician at St James Hospital, Dublin.1 Depending
FuturHealth Launches Affirm to Offer a Flexible, Transparent Way to Pay Over Time for GLP-1 …
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This Company Has a Sweet Pitch: A Healthier Cookie That May Even Help You Lose Weight
With GLP-1 drugs like Ozempic all the rage, ChipMonk Baking has created a cookie it says works a bit the same way.
GLP-1s outpace specialty drug spend for the first time: Report
GLP-1s are driving traditional drug spending in the U.S. to unprecedented levels, which now outpaces specialty drug spending for the first time, according to a March 25 report from Evernorth.
Novo Nordisk Expands Discounted Wegovy to All Cash-paying US Customers
Novo Nordisk said on Monday all eligible cash-paying customers in the United States can buy its weight-loss drug Wegovy at a discounted price of $499 per month at their… Reuters
The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism
Tirzepatide, a dual GIP/GLP-1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose
GLP-1 RAs Unlikely to Increase Suicide Risk
Patients with diabetes or obesity receiving GLP-1 RAs are unlikely to experience an increase in the already low rates of suicide-related adverse events in clinical trials. Medscape Medical News
Next-gen weight-loss drugs will be here within 12 months
It was only a matter of time until the GLP-1 receptor agonist drugs like Ozempic and Wegovy were superseded, and now it looks like we’ll have the next generation of
Amy Schumer Reveals the ‘Great’ Weight Loss Drug She’s Taking After Stopping Wegovy
Amy Schumer is keeping people updated on her health. The 43-year-old comedian informed fans about her experience with taking an alternative weight loss drug called Mounjaro, after she couldn’t handle
In a $2B deal, Novo licenses obesity drug from China’s United Bio
Building upon its already impressive obesity drug portfolio, Novo Nordisk A/S has licensed a triple agonist of the receptors for GLP-1, GIP and glucagon from United Biotechnology Co. Ltd. China-based
Will FDA deadlines reduce compounded versions of Ozempic?
With a FDA deadline set for March 26 to stop compounding versions of Zepbound, followed by restrictions on compounded Ozempic and Wegovy set for later this spring, the agency is
New Drug Delivery System Could Reduce GLP-1 Shortage and Make It More Efficient
Learn how chemists have invented a new technology to solve the shortage of GLP-1 medications by improving drug delivery.
I’m Whipping My Butt Back Into Shape This Spring With The Help Of Huel Black Edition Protein
Huel Black Edition protein I’ve been loving Huel’s Ready-To-Drinks, but that’s only half of what the Black Edition collection has to offer. Maybe you’re more of a scoop-shake-drink kind of
Novo Nordisk Bets $200M on Triple-Targeting Drug for Obesity and Other Metabolic Diseases
Novo Nordisk is licensing rights to a United Biotechnology drug that sparks metabolic effects by binding to and activating receptors for GLP-1, GIP, and glucagon. Separately, the pharma giant said
Licensed Clinical Care Advocate
A company is looking for a Clinical Care Advocate to support patients by addressing inquiries and ensuring a seamless patient experience. Key Responsibilities Serve as the primary point of contact
Novo Nordisk pens $2B deal for triple G agonist tied to 15% weight loss at 12 weeks
The candidate at the center of the deal, dubbed UBT251, is a triple agonist for glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP) and glucagon.
STAT+: Pharmalittle: We’re reading about 23andMe bankruptcy filing, the case against ‘global freeloading,’ and more
Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that oh-so-familiar routine of meetings, deadlines, and messages has returned. But
Novo Nordisk pays $200M upfront for China-based biotech’s triple-G obesity shot – Endpoints News
Novo Nordisk pays $200M upfront for China-based biotech’s triple-G obesity shot Endpoints News Novo Signs $2 Billion Deal With United Labs for Obesity Drug Bloomberg The United Laboratories and Novo Nordisk announce
The Return of Meat
Making America healthy again, it seems, starts with a double cheeseburger and fries. Earlier this month, Health Secretary Robert F. Kennedy Jr. visited a Steak ’n Shake in Florida and
US Patent Office Grants Closed Loop Medicine Key Patents for Cardiometabolic Capabilities in GLP-1 and Direct Oral Anti-Coagulants (DOAC) Therapies
LONDON–(BUSINESS WIRE)–Closed Loop Medicine Ltd., a leader in AI-enabled precision medicines, today announced the expansion of its US patent portfolio. Strengthening its cardiometabolic treatment portfolio, the Company now has patents
Butyrate — The Gut-Brain Axis Connector That Influences Mood and Cognition
Butyrate, a short-chain fatty acid (SCFA) produced in your colon through the bacterial fermentation of dietary fiber, is a metabolite byproduct that nourishes your colonocytes (i.e., the cells lining your
Ozempic Is… Awesome
The problem with Ozempic is that it works too well for obesity and weight loss. Imagine losing weight simply because you’re not hungry. Imagine suddenly disliking the taste of your