[Articles] Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial

Once-weekly ecnoglutide 0·6 mg and 1·2 mg were non-inferior to dulaglutide 1·5 mg in reducing HbA1c in adults with type 2 diabetes and elevated glucose concentrations on metformin monotherapy. Although

Read More »

Good Ideas Will Save the Country

One query I get often is “What class/skill would you suggest our kids take/learn to compete in the modern economy?” A few years ago, people expected me to say STEM,

Read More »

Serena Williams Says GLP-1s Changed Her Life

Photo: Stefanie Keenan/Getty Images for Vogue Three years after announcing her retirement from tennis, Serena Williams has a new job: advertising weight-loss medication. In an interview with Vogue, she revealed

Read More »

[Articles] Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

This study provides the first clinical evidence that antisense-mediated inhibition of DGAT2 with ION224 could be a safe and efficacious strategy for the treatment of MASH. The observed histological improvements

Read More »

Association of Semaglutide and NAION Reviewed

To the Editor Cai et al recently provided evidence about whether the glucagonlike peptide-1 receptor agonist (GLP-1RA) semaglutide is associated with nonarteritic anterior ischemic optic neuropathy (NAION). This is one

Read More »

Podcast: What’s a Safer and Cheaper Way to Lose Weight Than GLP-1 Drugs?

Tackling the root cause of obesity. This episode features audio from: https://nutritionfacts.org/video/obesity-is-a-glp-1-deficiency-its-cause-and-how-to-treat-it-without-ozempic-and-other-drugs/ Visit the video page for all sources and doctor’s notes related to this podcast. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe

Read More »

Comment on Lee et al. Comparative Efficacy of Glucagon-Like Peptide 1 Receptor Agonists for Cardiovascular Outcomes in Asian Versus White Populations: Systematic Review and Meta-analysis of Randomized Trials of Populations With or Without Type 2 Diabetes and/or Overweight or Obesity. Diabetes Care 2025;48:489–493

We read with great interest the recent meta-analysis examining the comparative efficacy of GLP-1 receptor agonists (GLP-1RAs) on cardiovascular outcomes across Asian and White populations (1). While the findings are

Read More »