Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03645-3 The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonist-induced weight loss.

Eli Lilly Skyrockets After Promising Results for First Weight-Loss Pill

After the tireless, incredible work by the scientists involved, the marketing team will barely have to lift a finger to come up with something catchier than orforglipron, as the company’s potentially game-changing drug has been dubbed. Eli Lilly announced trial results Thursday that suggested the experimental pill for diabetes and weight loss is just as … Read more

Daily weight-loss pill could be as effective as injectables

The News Eli Lilly’s share price soared after it said a daily weight-loss pill showed similar results to injectable drugs Ozempic and Mounjaro. Orforglipron helped patients lose an average 7.9% of their body weight in 40 weeks in clinical trials, compared with the 1.6% weight lost by those taking a placebo. The drug was less … Read more

Who could take new weight-loss pill – and who should avoid it

The first daily weight-loss pill is expected to be available in the UK as soon as next year after a trial found it to be effective in treating obesity and diabetes. The drug, developed by Eli Lilly and called orforglipron, targets the same GLP-1 receptors as injectable weight loss drugs such as Ozempic, Wegovy and Mounjaro. … Read more

Orforglipron Demonstrated Statistically Significant Efficacy Results and a Safety Profile Consistent with Injectable GLP-1 Medicines in Successful Phase 3 Trial

INDIANAPOLIS, April 17, 2025 /PRNewswire/ — Eli Lilly and Company (NYSE: LLY) today announced positive topline Phase 3 results from ACHIEVE-1, evaluating the safety and efficacy of orforglipron compared to placebo in adults with type 2 diabetes and…