Companies seek second GLP-1 revolution—in pill form
Science, Volume 388, Issue 6744, Page 241-242, April 2025.
Apr 18
Major drug company reveals crucial weight-loss pill breakthrough
It’s little secret that America has a weight problem. For decades, Americans have embraced and abandoned countless weight-loss strategies, including fad diets, that have proven ineffective long term. Despite our best efforts, more people are at risk of health complications resulting from obesity, including type 2 diabetes and heart disease. Related: UnitedHealth stock tumbles after Medicare Advantage … Read more
Daily GLP-1 pill effective for diabetes and obesity, Eli Lilly says
A daily pill from drugmaker Eli Lilly has shown similar effectiveness at helping people reduce blood sugar levels and lose weight compared to leading injectable GLP-1 drugs Mounjaro and Ozempic, the company announced. The once-daily pill, called orforglipron, helped patients with Type 2 diabetes during late-stage trials and has shown comparable safety results to the … Read more
Semaglutide and Risk of NAION—Additional Insights
In the current issue of JAMA Ophthalmology, Cai and colleagues report a small increase in the relative incidence of nonarteritic anterior ischemic optic neuropathy (NAION) due to semaglutide, a glucagonlike peptide 1 receptor agonist (GLP-1RA). The authors captured data from 14 databases within the Observational Health Data Sciences and Informatics network, which is an international … Read more
Reduced insulin use and diabetes complications upon introduction of SGLT-2 inhibitors and GLP1-receptor agonists in low- and middle-income countries: A microsimulation
by Global Health & Population Project on Access to Care for Cardiometabolic Diseases (HPACC) Background Diabetes mellitus, particularly type 2 diabetes, is a growing health concern in low- and middle-income countries (LMICs). The potential impact of newer diabetes medications, such as glucagon-like peptide 1 (GLP-1) receptor agonists and sodium-glucose co-transporter-2 (SGLT-2) inhibitors, on insulin dosage … Read more
New Eli Lilly-made GLP-1 pill could work as well as its injectable Mounjaro, Zepbound
A new pill taken orally could be as effective for type 2 diabetes and weight loss as comparable injectable products, Eli Lilly announced Thursday.
Eli Lilly’s Metabolic Medicine Takes the Lead in the Race to Develop an Oral GLP-1 Drug
The first Phase 3 results for Eli Lilly’s daily pill orforglipron show statistically significant reductions in blood sugar and body weight in patients with type 2 diabetes. The pharmaceutical giant plans global regulatory submissions starting at the end of this year. The post Eli Lilly’s Metabolic Medicine Takes the Lead in the Race to Develop … Read more
I’ve lost 115lb on Mounjaro – yes I have loose skin but my hubby doesn’t mind, and we can finally try for our dream baby
A STUDENT nurse is one step closer to her dream of having a baby after shedding 115lbs on Mounjaro. Laurie Murray, from Airdrie, started using the weight loss jabs last April when she tipped the scales at 18st 10lbs. tiktok/@lauriewendymBefore weight loss jabs she was turned away for fertility help on the NHS[/caption] tiktok/@lauriewendymLaurie Murray … Read more
Fructose Metabolism, Luteolin, and the Future of Metabolic Health
Hi r/supplements — I want to share some emerging research around fructose metabolism and a natural compound called Luteolin that I believe could be foundational to how we understand metabolic disease. First, full disclosure: I’m the founder of a company developing supplements targeting this pathway. I won’t name the company or link to any products … Read more