Apr 24

Nature Reviews Drug Discovery, Published online: 25 April 2025; doi:10.1038/s41573-025-01183-8 GLP-1-based therapies represent highly effective treatments for patients with type 2 diabetes and obesity. This Review profiles established and emerging GLP-1-based medicines, focusing on novel GLP-1 receptor agonists and GLP-1-based multi-agonists. Considerations and challenges in the development of GLP-1-based therapies and potential future indications are … Read more

While some Americans might feel doubtful about prescriptions, others are doing all they can to acquire GLP-1 drugs. Carly Johnson of Momentum Worldwide says the results of a new survey show just how popular they are. If you spend even a little bit of time online, you’ve probably seen the social discourse around prescription medications … Read more

BLOCKBUSTER ‘Ozempic-style’ fat jabs could increase the risk of depression and suicidal thoughts, experts have warned. The injections have allegedly helped celebs like Sun columnist Jeremy Clarkson, Sharon Osbourne and ex-Prime Minister Boris Johnson to shed some pounds. GettyScientists think fat jabs upset dopamine levels in the brain and raise the risk of depression, anxiety, and suicidal thoughts[/caption] Since … Read more

Experts express alarm that GLP-1 RAs may trigger or worsen eating disorders. But is there any role they might play in binge eating disorder? And how can clinicians protect patients from risk? Medscape Medical News

BACKGROUND Glucagon-like peptide 1 receptor agonists (GLP-1RA) reduce the incidence of major adverse cardiovascular events (MACE) in type 2 diabetes (T2D), although whether benefits extend to both subcutaneous and oral formulations remains unclear. PURPOSE In these meta-analyses, including new data from the Semaglutide cardiOvascular oUtcomes triaL (SOUL) (oral semaglutide) and Evaluate Renal Function with Semaglutide … Read more

A new expert review endorses GLP-1 RAs and other medications for sustainable weight loss in children with obesity and MASLD. Medscape Medical News

GLP-1 medications have been going viral for their transformative effects, but now people are raising concerns about a worrying new side-effect. Is it something to worry about or just a social media scare? We spoke with a doctor to find out

I congratulate Messiah et al on their publication entitled “Metabolic and Bariatric Surgery (MBS) Utilization in the Era of GLP-1 Receptor Agonists (GLP-1RA) among Adolescents Versus Adults.” The authors show an increase in adolescent MBS utilization from 2021-2023, which contrasts with adult data. This observation is interesting in the advent of second-generation GLP-1RAs (liraglutide and … Read more