GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01294-x This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

Journal Article – “Body Composition Metrics as a Determinant of Trastuzumab Deruxtecan Related Toxicity and Response”

Yaacobi Peretz, S., Kessner, R., Bar, Y. et al. Body composition metrics as a determinant of trastuzumab deruxtecan related toxicity and response. npj Breast Cancer 11, 38 (2025). https://doi.org/10.1038/s41523-025-00754-7 This scientific article explores the connection between a patient’s body composition and their experience with the drug trastuzumab deruxtecan (T-DXd) for metastatic breast cancer. Using computed tomography scans to measure muscle and … Read more

STAT+: The end of compounded GLP-1 copies leaves many patients in a ‘lose-lose’ position

The explosion of compounded GLP-1 offerings over the past two years is coming to an end, and many patients are left with no good options.  Blockbuster obesity and diabetes drugs — such as Wegovy, Ozempic, and Mounjaro — are no longer deemed by regulators to be in shortage, so compounding pharmacies and the telehealth companies … Read more

There’s a New Rapid Weight Loss Trend in Time for Summer: Skin Patches

Summer is approaching, and social media has been filled with reminders of its impending arrival. This year, there’s a clear revival of early 2000s trends, from outfits featuring Y2K hats and minimalistic tops to an increased focus on slim body types. The body positivity discourse seems to have dwindled, giving way to a renewed obsession … Read more