[Comment] Body composition during major incretin-based weight loss

We have witnessed weight loss of 13–15% with the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide and up to 18–23% with the dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist tirzepatide in people with obesity but without diabetes.1 In people with type 2 diabetes, weight loss seems to be somewhat lower, at 8–9% with semaglutide and 11–13% […]