⚖️ The History of Obesity
The provided text offers a comprehensive overview of how obesity has been understood and depicted across different historical periods, from ancient civilizations to the present day. It traces the evolution of obesity from being a symbol of wealth or a moral failing to its current recognition as a complex medical condition influenced by genetics, environment, and socioeconomic factors. The document highlights key shifts in medical understanding, […]
Mapping the off-target effects of every FDA-approved drug in existence
Published on July 13, 2025 3:21 PM GMT Thank you to Bill Busa, CEO and co-founder of EvE Bio, for an extremely helpful discussion while working on this essay. This essay is long, and I recognize that many people don’t necessarily care about the details. The real headline point you need to be aware of […]
Combination of obesity medication tirzepatide and menopause hormone therapy fuels weight loss
Using tirzepatide and menopause hormone therapy at the same time leads to increased weight loss in postmenopausal women with overweight or obesity compared to use of tirzepatide treatment alone, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.
Mouse study finds tirzepatide slowed obesity-associated breast cancer growth
The anti-obesity medication tirzepatide, marketed as Mounjaro for diabetes and Zepbound for obesity, reduced obesity-associated breast cancer growth in a mouse model, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.
Gastrointestinal stability and DPP-IV inhibitory activity of tilapia (Oreochromis niloticus) viscera hydrolysate-derived novel peptides LPCL and TPFLPDE, with LPCL-modulated GLP-1 and PepT1 expression in STC-1 cells
Publication date: November 2025 Source: Food Research International, Volume 219 Author(s): Rhessa Grace Guanga Ortizo, Ching-Shu Lai, Choirul Anwar, Vishal Sharma, Pei-Pei Sun, Chiu-Wen Chen, Cheng-Di Dong, Mei-Ling Tsai