🧬 Diverse Polygenic Scores for BMI and Obesity
The provided text details research on developing and validating a multi-ancestry polygenic score (PGS) for predicting body mass index (BMI) and obesity, significantly improving upon previous models. The study utilizes extensive genomic and phenotypic data from diverse populations, including those from the UK Biobank and the Million Veteran Program. Findings indicate this new PGS, known as PGSLC, offers enhanced predictive […]
Combining GLP-1 RA and Bariatric Surgery Ups Weight Loss
A study finds that adjunctive use of GLP-1 receptor agonists before and after undergoing bariatric surgery produces greater weight loss. Medscape Medical News
A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics
Nature Communications, Published online: 21 July 2025; doi:10.1038/s41467-025-61852-5 Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchanged β-cell PRLR abundance and absent β-cell 5-HT2B receptor expression.
Tirzepatide Outperforms Semaglutide on Combined T2D Goals
Tirzepatide outperformed semaglutide in simultaneously achieving four key therapeutic targets for type 2 diabetes. Medscape Medical News
A million veterans gave DNA to aid health research. Scientists worry the data will be wasted.
By Darius Tahir for KFF Health News One of the world’s biggest genetic databases comprises DNA data donated over the years by more than a million retired military service members. It’s part of a project run by the Department of Veterans Affairs. The initiative, dubbed the Million Veteran Program, is a “crown jewel of the country,” said […]
Eating foods in this order could help with weight loss and blood sugar, experts say
The order in which you eat foods during meals may affect your health, according to some nutrition experts. The concept — known as “meal sequencing” — involves first eating fiber-rich, non-starchy vegetables, followed by protein and then fats, before eating the carbohydrates on your plate. This orderly way of eating may help prevent blood sugar […]