Opinion: Obesity drugs don’t just offer weight loss. They give patients agency

Powerful new obesity drugs like Wegovy and Zepbound have changed how we treat weight and chronic disease. Yet their real promise may lie in the restored belief that we can meaningfully improve our health. As David Kessler, former commissioner of the Food and Drug Administration, has poignantly described, the struggle to lose weight can feel like […]

Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome?

Bardet-Biedl syndrome (BBS) is a complex genetic condition that can affect multiple organ systems, frequently causing pigmentary retinopathy, renal abnormalities, polydactyly, and obesity. Metabolic disturbances including obesity, unsuppressed appetite, and an increased risk of type 2 diabetes (T2D) present clinical management challenges. In this issue of the JCI, Singh et al. present a mouse model […]