Combo Semaglutide-Amylin Analogue Boosts Weight Loss Regardless of Diabetes
(MedPage Today) — CHICAGO — Adding investigational cagrilintide to a GLP-1 receptor agonist increased weight loss in adults with obesity with or without type 2 diabetes, a pair of phase IIIa trials found.
In REDEFINE 1, which included 3,417…
The Gut-Brain Axis Takes Center Stage
We’ve known about the gut-brain axis for decades but there has recently been an unprecedented jump in our knowledge base that has transformed our expectations for its preeminence. In this edition of Ground Truths I’m going to review some of the recent advances that are shaping the field, particularly for a new era of gut […]
Orforglipron for Early Type 2 Diabetes Management
This scientific paper presents the ACHIEVE-1 trial, a phase 3 study investigating orforglipron, an oral, nonpeptide GLP-1 receptor agonist, for treating type 2 diabetes. The research evaluates its efficacy and safety as a once-daily monotherapy in adults whose type 2 diabetes is managed solely through diet and exercise. The findings demonstrate that orforglipron significantly reduces glycated hemoglobin levels and promotes body weight reduction over […]
STAT+: Novo Nordisk’s amylin obesity drug keeps performing like Zepbound
Novo Nordisk’s next-gen weight loss drug and Zepbound “seem fairly equal to me,” one expert says after release of new late-stage results for CagriSema.
Caloric reset driven by GLP-1 drugs could cut food volumes by over 10%
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How Your Microbiome Influences Your Dietary Recommendations
Editor’s Note: This article is a reprint. It was originally published April 21, 2024. In the ever-evolving field of bioenergetic medicine, the relationship between our diet, microbiome and overall health continues to unveil complex and intriguing connections. At the heart of this exploration is the legacy of Ray Peat, Ph.D., whose theories on sugar intake […]
China’s Sciwind’s GLP-1 shows similar weight loss to Novo’s Wegovy, study finds – Reuters
China’s Sciwind’s GLP-1 shows similar weight loss to Novo’s Wegovy, study finds Reuters
Novel GLP-1 Agonist Promotes Safe and Effective Weight Loss
More than 90% of patients achieved clinically meaningful weight reduction compared to placebo in a phase 3 trial of ecnoglutide. Medscape Medical News
Novel Oral GLP-1 Agent Cuts A1c, Weight in Early Diabetes
(MedPage Today) — CHICAGO — An investigational, oral small-molecule GLP-1 receptor agonist improved glycated hemoglobin levels in adults with early-stage type 2 diabetes, a phase III randomized trial found. Among 559 participants in ACHIEVE…
Chinese biotech showcases challenger to Eli Lilly’s obesity drug
Once approved, Sciwind Biosciences’ obesity drug ecnoglutide will compete with Eli Lilly’s Zepbound and Novo Nordisk’s Wegovy. (Reuters pic) BEIJING: An obesity drug from China helped patients lose a lot of weight in a late-stage clinical trial, making it a prospective new challenger to blockbusters from Novo Nordisk A/S and Eli Lilly & Co. Hangzhou […]