China’s GLP-1 Shows Similar Weight Loss to Wegovy

Overweight patients given an experimental weight loss drug being developed by China’s Sciwind Biosciences lost an average of 10% to 15% of their body weight, roughly in line… Reuters Health Information

STAT+: Novo Nordisk ends deal with Hims due to compounding concerns with obesity drugs

Novo Nordisk is ending a deal with telehealth company Hims & Hers, saying Monday that Hims has been engaging in “illegal mass compounding” of GLP-1 obesity treatments and “deceptive marketing.” Earlier this year Novo launched a direct-to-consumer website that sells Wegovy at a lower price to patients who are paying on their own without insurance. […]

Med14 phosphorylation shapes genomic response to GLP-1 Agonist

Under feeding conditions, release of glucagon-like peptide (GLP-1) from intestinal L cells promotes insulin secretion and pancreatic beta cell viability. Binding of GLP-1 to its cognate receptor on the beta cell surface results in induction of the cAMP signaling pathway, leading to the protein kinase A (PKA) mediated phosphorylation of CREB and induction of CREB […]

STAT+: Eli Lilly drug preserves lean mass in patients losing weight on Wegovy

CHICAGO — An investigational therapy from Eli Lilly helped preserve lean mass and drive greater loss of fat in patients taking the popular obesity treatment Wegovy. In a Phase 2 trial, patients taking the highest-dose combination of Wegovy and the drug, called bimagrumab, lost 22% of their weight at 72 weeks. Ninety-three percent of that […]