Weight-Loss Drugs’ Environmental Cost

Experts warn that current methods of making the peptide drugs are environmentally unfriendly April 28, 2024 by Aayushi Pratap Chemical & Engineering News, Volume 102, Issue 13 This article explores the significant environmental challenges associated with the rapidly increasing production of popular peptide-based weight-loss drugs like Wegovy and Zepbound. It highlights that current manufacturing methods, primarily solid-phase peptide … Read more

FDA Accepts Novo Nordisk’s Application for Oral Wegovy: 5 Things to Know

A Wegovy weight loss pill from Novo Nordisk is forthcoming, providing an alternative to injectable GLP-1 drugs. Mads Claus Rasmussen/Ritzau Scanpix/AFP via Getty Images Federal regulators have accepted Novo Nordisk’s application to produce a pill version of its injectable weight loss medication Wegovy. Experts say an oral medication might be easier for people to use, … Read more

GLP-1 reduces adverse cardiac events before weight loss: 3 notes

Adult patients taking Wegovy saw a reduced risk of experiencing a major adverse cardiovascular event within the first three months of treatment, according to a secondary analysis of the drug’s clinical trial data, presented May 12 at the European Congress on Obesity. Here are three notes from the secondary analysis: The “Semaglutide and Cardiovascular Outcomes … Read more

Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides

Physical activity is essential for body weight maintenance after body weight-loss, partly by promoting the coupling between energy intake and expenditure. However, the underlying mechanisms remain largely unknown. Here we demonstrate that running induces small intestine growth independently of GLP-2. In addition, exercise increases L-cell density in the small intestine and glucose-stimulated GLP-1 secretion, and … Read more

Nature’s Ozempic: What and how you eat can increase levels of GLP-1 without drugs

Despite the popularity of semaglutide drugs like Ozempic and Wegovy for weight loss, surveys suggest that most people still prefer to lose weight without using medications. For those preferring a drug-free approach to weight loss, research shows that certain nutrients and dietary strategies can naturally mimic the effects of semaglutides.