US Chronic Disease Burden Versus Peers

There is a significant burden of chronic diseases in the United States, comparing its rates to other developed nations. One source from the Peterson-KFF Health System Tracker points out that the U.S. has higher rates of many chronic illnesses, including obesity, diabetes, and asthma, compared to its peers, contributing to higher death rates and shorter life expectancy. The […]

We know exercise is good for you. Why? He‘s working on it.

Health We know exercise is good for you. Why? He‘s working on it. Building on decades of research, Robert Gerszten seeks to pinpoint movement’s molecular benefits Anna Lamb Harvard Staff Writer May 21, 2025 4 min read Robert Gerszten in his lab. Veasey Conway/Harvard Staff Photographer Part of the Profiles of Progress series We know […]

Scientists Discover Powerful Anti-Cancer Benefits of Popular Weight Loss Drugs

After adjusting for the weight loss benefits of surgery, GLP-1 drugs were linked to a 41% lower risk of obesity-related cancer. New research presented at the European Congress on Obesity (ECO) in Malaga, Spain, and published in the journal eClinicalMedicine, suggests that some widely used weight-loss medications may do more than just help people slim […]

What are GLP-1 medications?

GLP-1s are drugs that help people manage diabetes and lose weight. Their surging popularity has a range of economic and public health implications.

Trump Won’t Force Medicaid to Cover GLP-1s for Obesity. A Few States Are Doing It Anyway.

CHARLESTON, S.C. — When Page Campbell’s doctor recommended she try an injectable prescription drug called Wegovy to lose weight before scheduling bariatric surgery, she readily agreed. “I’ve struggled with my weight for so long,” said Campbell, 40, a single mother of two. “I’m not opposed to trying anything.” In early April, about four weeks after […]

GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice

Nature Communications, Published online: 21 May 2025; doi:10.1038/s41467-025-59773-4 Early drivers of T2D include ectopic fat accumulation that impairs insulin sensitivity. Here, the authors show that GLP1/GCGR dual agonism provides multimodal benefits in obese male mice by reducing liver fat and improving insulin sensitivity resulting in endogenous β-cell recovery.