Thyroid – COC.org

Pancreatic Cancer - Obesity Reviews, Recent Papers, and Clinical Trials

To see all of the 15 Reviews, go directly to PubMed.

REVIEWS from PubMed – November 12, 2023 – Obesity (in title) AND Cancer (in title) AND thyroid (in title) AND Review

Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence October 23, 2024
CONCLUSION: This systematic review highlights the complex relationship between metabolic obesity phenotypes and thyroid cancer risk. The findings highlighted the importance of considering metabolic status alongside obesity in thyroid cancer risk assessment and intervention strategies.
Mehdi Hedayati
Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies June 27, 2024
CONCLUSION: The synthesis of 27 studies with diverse designs and populations underscores a robust positive association between adiposity and TC risk, providing compelling evidence for the potential role of increased adiposity in TC development.
Behnaz Abiri
Obesity and thyroid cancer risk July 6, 2023
PURPOSE OF REVIEW: This review explores recent evidence assessing the relationship between obesity and thyroid cancer.
Lauren C Burrage
Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management? October 7, 2022
INTRODUCTION: Several studies have focused on the relationship between obesity and differentiated thyroid carcinoma (DTC), particularly papillary histotype (PTC). However, the association of obesity with both incidence and aggressiveness of PTC is still incompletely understood.
Antonio Matrone
Obesity and Thyroid Cancer Risk: An Update February 15, 2022
Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence has increased dramatically in recent years. In parallel, the prevalence of overweight and obesity has also increased, suggesting a possible link between these two diseases. Indeed, low-grade chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in […]
Fabiana Franchini
Morbid Obesity and Thyroid Cancer Rate. A Review of Literature April 30, 2021
In the past three decades, several recent studies have analyzed the alarming increase of obesity worldwide, and it has been well established that the risk of many types of malignancies is increased in obese individuals; in the same period, thyroid cancer has become the fastest growing cancer of all malignancies. We investigated the current literature […]
Stefania Masone
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity April 5, 2021
In recent decades, the incidence and diagnosis of thyroid cancer have risen dramatically, and thyroid cancer has now become the most common endocrine cancer in the world. The onset of thyroid cancer is insidious, and its progression is slow and difficult to detect. Therefore, early prevention and treatment have important strategic significance. Moreover, an in-depth […]
Yuanyuan Zhou
Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer - Pooled results of 24 million cohorts November 10, 2020
CONCLUSIONS: Obesity is associated with higher risk of developing TC in women. However, maintaining a healthy weight is associated with reduced risk of TC in both women and men. Shifting our practice to include weight control strategies will help lead to cancer prevention.
Mohanad R Youssef
Obesity as a risk factor for thyroid cancer August 3, 2020
PURPOSE OF REVIEW: In this review, we evaluate recent findings related to the association between obesity and thyroid cancer.
Antonio Matrone
Association between subjective symptoms and obesity and postoperative recurrence in differentiated thyroid cancer: a matched-pair analysis March 1, 2020
Several patients with thyroid cancer experience symptom distress after diagnosis and surgery. Data on the association between symptomatology and disease recurrence are limited. A retrospective review of a prospectively maintained database was performed, and 57 patients who had recurrence after operation of differentiated thyroid cancer were identified. Controlling for age, sex, surgery, and tumour stage, […]
Yu-Ying Wu
The impact of obesity and insulin resistance on thyroid cancer: A systematic review May 29, 2019
In recent decades, there has been a marked increase in the prevalence of thyroid cancer. This phenomenon has paralleled the increase in the prevalence of obesity worldwide, which is associated with insulin resistance. Associations between these entities have been hypothesized, mainly for older and female populations, but they remain unclear. The aim of this article […]
Arya Harikrishna
Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models January 21, 2018
Recent compelling epidemiological studies indicate a strong association of obesity with thyroid cancer. Obesity has been shown to promote thyroid cancer progression and exacerbate poor outcome in thyroid cancer patients. However, the molecular mechanisms by which obesity increases thyroid cancer risk and facilitates cancer progression are not completely understood. Obesity induces complex pathological changes including […]
Won Gu Kim
Relationship between obesity, diabetes and the risk of thyroid cancer March 22, 2015
CONCLUSION: Our results show that obesity and, to a lesser degree, DM are significantly associated with DTC. BMI in particular was a strong predictive variable for DTC (C=0.82 bivariate, C=0.84 multivariate).
Benjamin Oberman
Obesity and thyroid cancer April 18, 2014
Many studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent […]
Marjory Alana Marcello
Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms September 17, 2013
The incidence of thyroid cancer has been rising over the past few decades along with a parallel increase in obesity. Observational studies have provided evidence for a potential association between the two. By contrast, clinical data for a link between type 2 diabetes mellitus, a condition strongly associated with obesity, and thyroid cancer are limited […]
K Pazaitou-Panayiotou
Obesity and thyroid cancer: a clinical update July 25, 2013
CONCLUSIONS: Given the rising prevalence of TC and the development of obesity as an epidemic, it is important to clarify its connection with TC as well as the mediating pathways. However, unless this association is confirmed and causation proven, screening for TC in overweight and obese subjects-a rapidly increasing body of the general population-does not […]
Theodora Pappa
Obesity and thyroid cancer January 4, 2011
With the current trend of alarming rise in obesity rates, the health impacts of excess weight will become more apparent. While an increased incidence of cardiovascular disease and diabetes mellitus has been well documented, the association between obesity and carcinogenesis is just being appreciated and is receiving increasing attention. The current review focuses on the […]
Tamara Mijovic

To see all 63 Papers, go directly to PubMed.

RECENT PAPERS from PubMed – November 13, 2023 – Ofbesity (in title) AND Cancer (in title) AND Thyroid (in title)

Elucidating macrophage scavenger receptor 1's mechanistic contribution as a shared molecular mediator in obesity and thyroid cancer pathogenesis via bioinformatics analysis November 6, 2024
INTRODUCTION: Obesity is a disease characterized by the excessive accumulation of fat. Concurrently, thyroid carcinoma (THCA) stands as the foremost endocrine malignancy. Despite the observed escalation in concurrent prevalence of both conditions, the underlying interconnections remain elusive. This indicates the need to identify potential biomarkers to predict the pathways through which obesity and THCA coexist.
Fangjian Shang
Associations Between Obesity and Risk of Thyroid Cancer: A Meta-Analysis of Cohort Studies October 26, 2024
Previous cohort studies have shown conflicting findings on the associations between obesity and the risk of thyroid cancer. This meta-analysis aimed to investigate the associations between them by using a meta-analysis of cohort studies. PubMed and EMBASE were searched using keywords from inception until November 2023 to identify relevant studies on this topic. Two authors […]
Urfa Khairatun Hisan
Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence October 23, 2024
CONCLUSION: This systematic review highlights the complex relationship between metabolic obesity phenotypes and thyroid cancer risk. The findings highlighted the importance of considering metabolic status alongside obesity in thyroid cancer risk assessment and intervention strategies.
Mehdi Hedayati
Clinical Impact of Obesity on Postoperative Outcomes of Patients With Thyroid Cancer Undergoing Thyroidectomy: A 5-Year Retrospective Analysis From the US National Inpatient Sample October 17, 2024
CONCLUSION: Obesity is associated with an increased risk of postoperative complications in patients with thyroid cancer undergoing thyroidectomy. This finding suggests that obese patients should be treated with more caution during postoperative recovery.
Yue Chen
Uncovering the connection between obesity and thyroid cancer: the therapeutic potential of adiponectin receptor agonist in the AdipoR2-ULK axis September 30, 2024
Adiponectin, a unique adipose-derived factor, is significantly downregulated in obesity, making it a crucial target for tumor-related metabolic research. AdipoRon is a novel adiponectin receptor agonist with the advantages of a small molecular weight, high stability and a long half-life. By screening the cervical adipose tissue of papillary thyroid carcinoma (PTC) patients with adipokine antibody […]
Changlin Li
Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies June 27, 2024
CONCLUSION: The synthesis of 27 studies with diverse designs and populations underscores a robust positive association between adiposity and TC risk, providing compelling evidence for the potential role of increased adiposity in TC development.
Behnaz Abiri
Sex-dependent impact of obesity on aggressiveness of papillary thyroid cancer December 19, 2023
CONCLUSIONS: Overweight and obesity were predominant independent risk factors for PTC aggressiveness in males. These data indicated that the therapeutic treatment should be based on risk stratification by BMI in males.
Xiu Huang
Weighty Matters: The Obesity-Thyroid Nodule Connection Unveiling the Impact of Obesity on Thyroid Cancer Risk September 28, 2023
Background and Objectives: The effect of obesity on the development/progression of thyroid nodules with uncertain cytology is unknown. Therefore, our objective was to assess the role of body mass index (BMI) in predicting malignancy in patients with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) nodules. Materials and Methods: We retrospectively analyzed 113 patients […]
Saad M Alqahtani
Obesity and thyroid cancer risk July 6, 2023
PURPOSE OF REVIEW: This review explores recent evidence assessing the relationship between obesity and thyroid cancer.
Lauren C Burrage
Obesity, obesity-related metabolic conditions, and risk of thyroid cancer in women: results from a prospective cohort study (Sister Study) June 22, 2023
BACKGROUND: Thyroid cancer incidence has increased worldwide. Obesity trends may play a role, but the underlying biological pathways are not well-characterized. Therefore, we examined associations of excess adiposity and obesity-related metabolic conditions with thyroid cancer incidence.
Elisa Pasqual
Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer November 17, 2022
CONCLUSION: BFP and BSA, possibly influenced by gender, were positively associated with the number and risk of LNM in different regions of PTC patients. However, BMI was not the predictor for aggressiveness of PTC in terms of LNM. Clinical decision-making for regional LNM in PTC patients should consider the factor of obesity.
Wan-Xiao Wu
Obesity, Physical Activity, and Thyroid Cancer Risk: Disentangling True Associations from Detection Bias November 10, 2022
No abstract
Cari M Kitahara
Risk factors in thyroid cancer: is the obesity pandemic an important factor? November 8, 2022
No abstract
Antonio Matrone
Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case-Control Study October 14, 2022
Objective: This study aimed to identify the association between various obesity indexes, including waist circumference (WC), waist−hip ratio (WHR), waist−height ratio (WHTR), and BMI, and their combinations with body mass index (BMI) and thyroid cancer risk. Methods: Of the 65,639 participants who completed a follow-up survey of the Health Examinee Study (HEXA), a prospective cohort […]
Yoonyoung Jang
Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management? October 7, 2022
INTRODUCTION: Several studies have focused on the relationship between obesity and differentiated thyroid carcinoma (DTC), particularly papillary histotype (PTC). However, the association of obesity with both incidence and aggressiveness of PTC is still incompletely understood.
Antonio Matrone
Thyroid cancer incidence trend and association with obesity, physical activity in the United States July 13, 2022
CONCLUSIONS: Thyroid cancer incidence in 10 states continued increasing. State-level variation in race/ethnicity and age group incidence were found. Lifestyle and environmental factors may interfere with the incidence trend of TC in the USA.
Biaoyou Chen
Obesity and Thyroid Cancer Risk: An Update February 15, 2022
Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence has increased dramatically in recent years. In parallel, the prevalence of overweight and obesity has also increased, suggesting a possible link between these two diseases. Indeed, low-grade chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in […]
Fabiana Franchini
Association of Metabolic Health and Central Obesity with the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study December 22, 2021
CONCLUSIONS: Metabolically unhealthy women or women with central adiposity may be at an increased thyroid cancer risk despite normal BMI.
Dung N Nguyen
Morbid Obesity and Thyroid Cancer Rate. A Review of Literature April 30, 2021
In the past three decades, several recent studies have analyzed the alarming increase of obesity worldwide, and it has been well established that the risk of many types of malignancies is increased in obese individuals; in the same period, thyroid cancer has become the fastest growing cancer of all malignancies. We investigated the current literature […]
Stefania Masone
Effects of concomitant obesity and diabetes on the aggressiveness and outcomes of differentiated thyroid cancer patients April 28, 2021
CONCLUSION: In this retrospective study we demonstrated that obesity and T2DM have no additive effect on DTC aggressiveness and response to therapy. DTC patients with obesity and diabetes can be treated according to present guidelines without requirement for spesific attention.
Onur Elbasan

Clinical Trials involving Thyroid Cancer and Obesity

NCT Number	Study Title	Study URL	Acronym	Study Status	Interventions	Sponsor	Collaborators	Enrollment	Study Type	Locations
NCT05687188	Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations	https://clinicaltrials.gov/study/NCT05687188		ACTIVE_NOT_RECRUITING	OTHER: Blood Sample Collection\|OTHER: Tissue Sample Collection\|OTHER: Data Collection\|OTHER: Medical Image Collection	H. Lee Moffitt Cancer Center and Research Institute	United States Department of Defense	91	OBSERVATIONAL	Moffitt Cancer Center, Tampa, Florida, 33612, United States\|University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States
NCT03910387	Telotristat Ethyl to Promote Weight Stability in Patients With Advanced Stage Pancreatic Cancer	https://clinicaltrials.gov/study/NCT03910387		ACTIVE_NOT_RECRUITING	DRUG: Gemcitabine\|DRUG: Nab-paclitaxel\|DRUG: Telotristat Ethyl	Emory University	National Cancer Institute (NCI)\|Lexicon Pharmaceuticals	22	INTERVENTIONAL	Emory University Hospital Midtown, Atlanta, Georgia, 30308, United States\|Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, 30322, United States\|Emory Saint Joseph's Hospital, Atlanta, Georgia, 30342, United States
NCT03851133	Florida Pancreas Collaborative Next Generation Biobank	https://clinicaltrials.gov/study/NCT03851133		ACTIVE_NOT_RECRUITING	OTHER: Blood Sample Collection\|OTHER: Tumor Sample collection\|OTHER: Data Collection	H. Lee Moffitt Cancer Center and Research Institute		500	OBSERVATIONAL	Lee Memorial Hospital Regional Cancer Center, Fort Myers, Florida, 33905, United States\|University of Florida - Gainesville, Gainesville, Florida, 32610-0109, United States\|Palmetto General Hospital, Hialeah, Florida, 33016, United States\|University of Florida - Jacksonville, Jacksonville, Florida, 32209, United States\|Lakeland Regional Health, Lakeland, Florida, 33805, United States\|Mount Sinai Medical Center, Miami Beach, Florida, 33140, United States\|Sylvester Comprehensive Cancer Center & Jackson Memorial Hospital, Miami, Florida, 33136, United States\|Advent Health - Orlando, Orlando, Florida, 32804, United States\|University of Florida - Orlando, Orlando, Florida, 32806, United States\|St Anthony's Baycare/Bay Surgical Specialists, Saint Petersburg, Florida, 33705, United States\|Sarasota Memorial Hospital, Sarasota, Florida, 34239, United States\|Tallahassee Memorial Healthcare, Tallahassee, Florida, 32308, United States\|University of South Florida/Tampa General Hospital, Tampa, Florida, 33606, United States\|H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, 33612, United States
NCT00344851	Exenatide and Metformin Therapy in Overweight Women With PCOS	https://clinicaltrials.gov/study/NCT00344851		COMPLETED	DRUG: metformin, exenatide or combined (metformin & exenatide )	Metabolic Center of Louisiana Research Foundation	Amylin Pharmaceuticals, LLC.	60	INTERVENTIONAL	Facility: Metabolic Center of Louisiana Research Foundation, Baton Rouge, Louisiana, 70808, United States
NCT05874726	Biological Sample Repository for Gastrointestinal Disorders	https://clinicaltrials.gov/study/NCT05874726		RECRUITING	DIAGNOSTIC_TEST: Blood Collection\|DIAGNOSTIC_TEST: Urine Collection\|DIAGNOSTIC_TEST: Tissue Sample Collection	Pichamol Jirapinyo, MD, MPH	Tufts University\|Boston Children's Hospital\|Mayo Clinic	500	OBSERVATIONAL	Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States
NCT02432950	Pancreatic Nutritional Program for Weight Loss in Overweight/Obese Patients With Stage I-III Breast Cancer	https://clinicaltrials.gov/study/NCT02432950		COMPLETED	DIETARY_SUPPLEMENT: Dietary Intervention\|OTHER: Educational Intervention\|OTHER: Laboratory Biomarker Analysis\|OTHER: Quality-of-Life Assessment	City of Hope Medical Center	National Cancer Institute (NCI)	21	INTERVENTIONAL	City of Hope Medical Center, Duarte, California, 91010, United States
NCT04068896	Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy	https://clinicaltrials.gov/study/NCT04068896		ACTIVE_NOT_RECRUITING	BIOLOGICAL: NGM120\|BIOLOGICAL: NGM120\|BIOLOGICAL: NGM120\|BIOLOGICAL: NGM120\|BIOLOGICAL: NGM120\|BIOLOGICAL: NGM120\|OTHER: Placebo	NGM Biopharmaceuticals, Inc		75	INTERVENTIONAL	NGM Clinical Study Site, Tucson, Arizona, 85719, United States\|NGM Clinical Study Site, Los Angeles, California, 90048, United States\|NGM Clinical Study Site, Los Angeles, California, 90084, United States\|NGM Clinical Study Site, Sacramento, California, 98517, United States\|NGM Clinical Study Site, San Diego, California, 92123, United States\|NGM Clinical Study Site, Santa Monica, California, 90404, United States\|NGM Clinical Study Site, Aurora, Colorado, 80045, United States\|NGM Clinical Study Site, Washington, District of Columbia, 20007, United States\|NGM Clinical Study Site, Miami, Florida, 33136, United States\|NGM Clinical Study Site, Chicago, Illinois, 60611, United States\|NGM Clinical Study Site, Baltimore, Maryland, 21201, United States\|NGM Clinical Study Site, Omaha, Nebraska, 68130, United States\|NGM Clinical Study Site, Charlotte, North Carolina, 28204, United States\|NGM Clinical Study Site, Cincinnati, Ohio, 45219, United States\|NGM Clinical Study Site, Philadelphia, Pennsylvania, 19111, United States\|NGM Clinical Study Site, Charleston, South Carolina, 29425, United States\|NGM Clinical Study Site, Myrtle Beach, South Carolina, 29572, United States\|NGM Clinical Study Site, Nashville, Tennessee, 37203, United States\|NGM Clinical Study Site, Dallas, Texas, 75390, United States\|NGM Clinical Study Site, Houston, Texas, 77030, United States\|NGM Clinical Study Site, Seattle, Washington, 98101, United States\|NGM Clinical Study Site, Milwaukee, Wisconsin, 53226, United States
NCT04210128	Glucose Monitoring to Predict and Treat High Glucose Levels After Steroid Treatment	https://clinicaltrials.gov/study/NCT04210128		COMPLETED		Memorial Sloan Kettering Cancer Center		3	OBSERVATIONAL	Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States
NCT02431676	Survivorship Promotion In Reducing IGF-1 Trial	https://clinicaltrials.gov/study/NCT02431676	SPIRIT	COMPLETED	DRUG: Metformin\|BEHAVIORAL: Coach Directed Behavioral Weight Loss\|BEHAVIORAL: Self-control weight loss	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Maryland Cigarette Restitution Fund	121	INTERVENTIONAL	Johns Hopkins ProHealth, Baltimore, Maryland, 21207, United States