Kommu S, Sharma PP, Gabor RM. Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Obes Rev. 2025 Jun 13:e13961. doi: 10.1111/obr.13961. Epub ahead of print. PMID: 40510020.
This article presents a systematic review and meta-analysis on the efficacy and safety of tirzepatide for weight loss in individuals without diabetes mellitus. It synthesizes data from six randomized controlled trials, demonstrating significant reductions in body weight, BMI, and waist circumference with tirzepatide compared to placebo. The review also highlights improvements in other health parameters like blood pressure and lipid profiles. While noting that serious adverse events were not significantly increased, the analysis reveals a higher incidence of gastrointestinal side effects and increased rates of treatment discontinuation due to these adverse events. Overall, the source concludes that tirzepatide is effective for weight loss in this population but requires careful monitoring due to its side effect profile.
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