Upper Stomach Cancer - Obesity, Recent Papers, and Clinical Trials
To see all 14 Papers, go directly to PubMed.
RECENT PAPERS from PubMed – November 12. 2023 -Stomach Cancer (in title) AND Obesity
- Cancer in the Excluded Stomach After Gastric Bypass Surgery for Obesity February 20, 2026CONCLUSION: Gastric bypass might increase the risk of adenocarcinoma in the excluded stomach and delay the detection when such tumors occur. Yet, this cancer is still rare after gastric bypass.Wilhelm Leijonmarck
- Smoking, Alcohol, and Abdominal Obesity Increase Gastric Cancer Risk after Helicobacter pylori Eradication January 8, 2026CONCLUSION: Unhealthy lifestyles like smoking, alcohol, and abdominal obesity were shown as risk factors for post-HPE GC. Those with late HPE were more likely to be affected by unhealthy lifestyles.Joo Hyun Lim
- Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation October 23, 2025CONCLUSION: Sarcopenic obesity (myosteatosis/visceral obesity) can identify poorer prognosis in gastric cancer patients, especially male patients. It is crucial for obese gastric cancer patients to evaluate their body composition, specifically focusing on fat distribution.Chun-Wei Li
- Impact of sarcopenic obesity on postoperative complications and long-term survival in patients with gastric cancer September 14, 2025CONCLUSIONS: SO is an independent prognostic factor in GC and should be incorporated into preoperative evaluation. Early intervention strategies targeting SO may help improve postoperative and survival outcomes.Yulong Wang
- Glucagon-like peptide-1 receptor agonists compared with bariatric metabolic surgery and the risk of obesity-related cancer: an observational, retrospective cohort study July 2, 2025BACKGROUND: Both obesity and diabetes are associated with increased risk for specific types of cancer, generally termed obesity-related cancer (ORC). Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and bariatric metabolic surgery (BMS) are well established treatments for diabetes and obesity, but their comparative effectiveness for the prevention of ORC is unknown. Here, we compare the incidence […]Yael Wolff Sagy
- Clinical benefits including the postoperative inflammatory status of robot-assisted distal gastrectomy for gastric cancer compared with laparoscopic distal gastrectomy in patients with obesity April 10, 2025This study aimed to clarify the clinical benefits of robot-assisted distal gastrectomy (RDG) versus laparoscopic distal gastrectomy (LDG) in patients with obesity.The analysis included 89 and 87 patients in LDG and RDG groups, respectively. The associations between body mass index (BMI) and surgical outcomes including postoperative inflammation were compared between LDG and RDG.Incidences of postoperative […]Kazuaki Matsui
- Hand Grip Strength and Body Composition According to the Sarcopenic Obesity Guidelines: Impact on Postoperative Complications in Patients With Gastric Cancer April 8, 2025CONCLUSIONS: In obese patients with gastric cancer, the preoperative prevalence of low HGS-obesity or low SMM-obesity differed significantly. One of the low SMM-obesity model was associated with postoperative complication after gastrectomy.Yoko Saino
- Impact of sarcopenic obesity on postoperative outcomes in patients with oesophago-gastric cancer: A systematic review and meta-analysis December 26, 2024CONCLUSIONS: Sarcopenic obesity worsens OS and increases the risk of postoperative complications in patients with oesophago-gastric cancer undergoing radical resection.Ryota Matsui
- Prevalence of sarcopenic obesity in patients with gastric cancer and effects on adverse outcomes: A meta-analysis and systematic review October 22, 2024CONCLUSIONS: The prevalence of sarcopenic obesity is high in patients with gastric cancer and is strongly associated with poor postoperative outcomes. Healthcare providers should evaluate patients with gastric cancer for sarcopenic obesity early to prevent or reduce the incidence of adverse outcomes.Bingyan Zhao
- Association between different patterns of obesity and the short-term outcomes of gastric cancer surgery October 17, 2024Previous studies have shown that general and central obesity are each linked to adverse outcomes in gastrointestinal cancers. However, their combined effect on gastrointestinal cancers surgery outcomes were less understood. This study aims to integrate both general and central obesity to examine the outcomes of gastric cancer surgery in different obesity patterns. We retrospectively analyzed […]Guoqing Shi
- A case report of Roux-en-Y gastric bypass combined with radical gastrectomy for severe obesity complicated with gastric cancer September 23, 2024No abstractJ D Li
- Obesity and its relationship with cancer September 16, 2024The aim of this study is to investigate how excess weight can influence cancer risk and the possible mechanisms involved. For this purpose, a bibliographic review was made of the studies published between 2000 and 2024 that analyze this relationship, as well as specific types of cancer associated with obesity. A significant association was found […]Ovidio Hernando-Requejo
- Impact of visceral fat obesity (obesity disease) on short- and long-term outcomes of laparoscopic gastrectomy in gastric cancer August 27, 2024CONCLUSION: Visceral fat accumulation strongly predicted postoperative morbidity. Despite increased perioperative risk, OD did not negatively impact successful lymphadenectomy or survival following LG.Kei Yamamoto
- Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity August 10, 2024Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of breast cancer, colorectal and stomach cancer, metabolic syndrome, heart diseases, diabetes, and obesity due to its anti-inflammatory and antioxidant properties. Also, its neuroprotective properties, improving cognitive function and protecting dopaminergic neurons, make it an excellent candidate for treating neurodegenerative […]Joanna Bartkowiak-Wieczorek
- Sarcopenic obesity predicts short- and long-term outcomes after neoadjuvant chemotherapy and surgery for gastric cancer June 28, 2024CONCLUSIONS: Pre-NAC SO was an independent prognostic factor in patients with LAGC undergoing NAC; post-NAC SO independently predicted postoperative morbidity.Chunning Duan
- Systematic review and meta-analysis of short-term outcomes: robot-assisted versus laparoscopic surgery for gastric cancer patients with visceral obesity June 4, 2024The objective of this meta-analysis was to assess the comparative efficacy of robot-assisted and laparoscopic surgery in treating gastric cancer among patients characterized by a high visceral fat area (VFA). In April 2024, we conducted a comprehensive literature review using major international databases, such as PubMed, Embase, and Google Scholar. We restricted our selection to […]Lin-Wen Yang
- Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay March 31, 2024Gastric cancer (GC) is a common malignant tumor worldwide, especially in East Asia, with high incidence and mortality rate. Epigenetic modifications have been reported to participate in the progression of gastric cancer, among which m⁶A is the most abundant and important chemical modification in RNAs. Fat mass and obesity-associated protein (FTO) is the first identified […]Xi Wu
- Muscle attenuation, not skeletal muscle index, is an independent prognostic factor for survival in gastric cancer patients with overweight and obesity March 9, 2024CONCLUSION: MA had a higher prognostic value than SMI in overweight and obese patients with gastric cancer after radical gastrectomy.Cheng-Le Zhuang
- The influence of Helicobacter pylori, proton pump inhibitor, and obesity on the gastric microbiome in relation to gastric cancer development December 11, 2023Helicobacter pylori infection is still the main risk factor for the development of gastric cancer (GC). We explore the scientific evidence for the role of the gastric microbiome beyond Helicobacter pylori (H. pylori) in gastric carcinogenesis. The composition of the gastric microbiome in healthy individuals, in presence and absence of H. pylori infection, in proton […]Chengliang Zhou
- The effect of sarcopenia and sarcopenic obesity on survival in gastric cancer September 28, 2023CONCLUSION: Sarcopenia is more prevalent in the elderly population and is linked to increased mortality in gastric cancer patients. Paradoxically, higher body mass index (BMI) was associated with improved survival. Computed tomography offers a practical and reliable method for measuring muscle mass and distinguishing these distinctions.Muzaffer Ece Hakan Şahin
Clinical Trials involving Stomach Cancer and Obesity
| NCT Number | Study Title | Study URL | Acronym | Study Status | Interventions | Sponsor | Collaborators | Enrollment | Study Type | Locations |
|---|---|---|---|---|---|---|---|---|---|---|
| NCT05874726 | Biological Sample Repository for Gastrointestinal Disorders | https://clinicaltrials.gov/study/NCT05874726 | RECRUITING | DIAGNOSTIC_TEST: Blood Collection|DIAGNOSTIC_TEST: Urine Collection|DIAGNOSTIC_TEST: Tissue Sample Collection | Pichamol Jirapinyo, MD, MPH | Tufts University|Boston Children's Hospital|Mayo Clinic | 500 | OBSERVATIONAL | Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States | |
| NCT00535990 | Minimally Invasive Surgery (MIS) Database for the Purpose of Research | https://clinicaltrials.gov/study/NCT00535990 | COMPLETED | University of California, San Diego | 250 | OBSERVATIONAL | University of California, San Diego, San Diego, California, 92103, United States | |||
| NCT01793168 | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | https://clinicaltrials.gov/study/NCT01793168 | CoRDS | RECRUITING | Sanford Health | National Ataxia Foundation|International WAGR Syndrome Association|4p- Support Group|ML4 Foundation|Cornelia de Lange Syndrome Foundation|Stickler Involved People|Kawasaki Disease Foundation|Klippel-Feil Syndrome Alliance|Klippel-Feil Syndrome Freedom|Hyperacusis Research Limited|Hypersomnia Foundation|Kabuki Syndrome Network|Kleine-Levin Syndrome Foundation|Leiomyosarcoma Direct Research Foundation|Marinesco-Sjogren Syndrome Support Group - NORD|Mucolipidosis Type IV (ML4) Foundation|People with Narcolepsy 4 People with Narcolepsy (PWN4PWN)|Soft Bones Incorporated|American Multiple Endocrine Neoplasia Support|Atypical Hemolytic Uremic Syndrome Foundation|All Things Kabuki|Wiedemann-Steiner Syndrome Foundation|Breast Implant Victim Advocates|PROS Foundation|American Behcet's Disease Association|Alstrom United Kingdom|Athymia|Curing Retinal Blindness Foundation|HSAN1E Society|1p36 Deletion Support and Awareness|The Alagille Syndrome Alliance|Autoinflammatory Alliance|Beyond Batten Disease Foundation|Bohring-Opitz Syndrome Foundation, INC|Cockayne Syndrome Network (Share and Care)|CRMO Foundation|Cure VCP Disease,INC|FOD Support|Cystinosis Research Foundation|Global DARE Foundation|Hypnic Jerk-Sleep Myoclonus Support Group|Jansen's Foundation|KCNMA1 Channelopathy International Advocacy Foundation|Kawasaki Disease Foundation Australia|Life with LEMS Foundation|Lowe Syndrome Association|The Malan Syndrome Foundation|Maple Syrup Urine Disease Family Support Group|International Association for Muscle Glycogen Storage Disease (IamGSD)|Myhre Syndrome Foundation|DNM1 Families|Nicolaides Baraitser Syndrome (NCBRS) Worldwide Foundation|The PBCers Organization|Pitt Hopkins Research Foundation|Progressive Familial Intrahepatic Cholestasis Advocacy and Resource Network, Inc|Recurrent Meningitis Association|Recurrent Respiratory Papillomatosis Foundation|Remember the Girls|Smith-Kingsmore Syndrome Foundation|SPG Research Foundation|Team Telomere|Transient Global Amnesia Project|The Charlotte & Gwenyth Gray Foundation|The Cute Syndrome Foundation|The Maddi Foundation|White Sutton Syndrome Foundation|Zmynd11 Gene Disorder|Cauda Equina Foundation, Inc|Tango2 Research Foundation|Noah's Hope - Hope4Bridget Foundation|Project Sebastian|SMC1A Epilepsy Foundation|International Foundation for Gastrointestinal Disorders|Endosalpingiosis Foundation, Inc|International Sacral Agenesis/Caudal Regression Association (ISACRA)|Scheuermann's Disease Fund|Batten Disease Support and Research Association|Kennedy's Disease Association|Cure Mito Foundation|Warburg Micro Research Foundation|Cure Mucolipidosis|Riaan Research Initiative|CureARS A NJ Nonprofit Corporation|CACNA1H Alliance|IMBS Alliance|SHINE-Syndrome Foundaion|Non- Ketotic Hyperglycinemia (NKH) Crusaders|Hypertrophic Olivary Degeneration Association (HODA)|National Organization for Disorders of the Corpus Callosum (NODCC) | 20000 | OBSERVATIONAL | Sanford Health, Sioux Falls, South Dakota, 57104, United States|Online Patient Enrollment System, Sydney, Australia | |
| NCT04068896 | Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy | https://clinicaltrials.gov/study/NCT04068896 | ACTIVE_NOT_RECRUITING | BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|BIOLOGICAL: NGM120|OTHER: Placebo | NGM Biopharmaceuticals, Inc | 75 | INTERVENTIONAL | NGM Clinical Study Site, Tucson, Arizona, 85719, United States|NGM Clinical Study Site, Los Angeles, California, 90048, United States|NGM Clinical Study Site, Los Angeles, California, 90084, United States|NGM Clinical Study Site, Sacramento, California, 98517, United States|NGM Clinical Study Site, San Diego, California, 92123, United States|NGM Clinical Study Site, Santa Monica, California, 90404, United States|NGM Clinical Study Site, Aurora, Colorado, 80045, United States|NGM Clinical Study Site, Washington, District of Columbia, 20007, United States|NGM Clinical Study Site, Miami, Florida, 33136, United States|NGM Clinical Study Site, Chicago, Illinois, 60611, United States|NGM Clinical Study Site, Baltimore, Maryland, 21201, United States|NGM Clinical Study Site, Omaha, Nebraska, 68130, United States|NGM Clinical Study Site, Charlotte, North Carolina, 28204, United States|NGM Clinical Study Site, Cincinnati, Ohio, 45219, United States|NGM Clinical Study Site, Philadelphia, Pennsylvania, 19111, United States|NGM Clinical Study Site, Charleston, South Carolina, 29425, United States|NGM Clinical Study Site, Myrtle Beach, South Carolina, 29572, United States|NGM Clinical Study Site, Nashville, Tennessee, 37203, United States|NGM Clinical Study Site, Dallas, Texas, 75390, United States|NGM Clinical Study Site, Houston, Texas, 77030, United States|NGM Clinical Study Site, Seattle, Washington, 98101, United States|NGM Clinical Study Site, Milwaukee, Wisconsin, 53226, United States | ||
| NCT02935478 | Bariatric Embolization of Arteries in Obese Patients With HCC to Allow Salvage Liver Transplantation | https://clinicaltrials.gov/study/NCT02935478 | SUSPENDED | DEVICE: Embospheres Microspheres | St. Louis University | 8 | INTERVENTIONAL | Saint Louis University, Saint Louis, Missouri, 63110, United States | ||
| NCT01047735 | The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes | https://clinicaltrials.gov/study/NCT01047735 | TRIABETES | ACTIVE_NOT_RECRUITING | PROCEDURE: Roux-en-Y Gastric Bypass Surgery|PROCEDURE: Laparoscopic Adjustable Gastric Banding|BEHAVIORAL: Lifestyle Weight Loss Intervention | University of Pittsburgh | National Institutes of Health (NIH)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 69 | INTERVENTIONAL | William F Gourash, Pittsburgh, Pennsylvania, 15213, United States |
| NCT05579444 | Systems Biology of Gastrointestinal and Related Diseases | https://clinicaltrials.gov/study/NCT05579444 | RECRUITING | Viome | 100000 | OBSERVATIONAL | Viome Life Sciences, Bothell, Washington, 98011, United States |