Oncobesity News Posts

Forget GLP-1s—GLP-3s show promise in phase 3 weight loss and diabetes trial

Phase 3 clinical trial results (TRANSCEND-T2D-1) published in The Lancet report that retatrutide, an investigational once-weekly injection for diabetes management, can significantly improve blood sugar levels and lead to substantial weight loss in people with Type 2 diabetes. The study included adults with Type 2 diabetes who were not taking diabetes medicines and whose blood sugar was not adequately controlled with diet and exercise alone.

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Study Compares GLP-1 Drugs on Their Benefits, Harms

(MedPage Today) — Variable weight-loss and cardiovascular benefits were seen with GLP-1 drugs in a systematic review and network meta-analysis, but effects on quality of life were less clear.
Across 262 randomized studies published through November…

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Societies combine to issue recommendations on use of incretin drugs in obesity therapy

Friday, July 10 – Obesity and dietitian societies have joined forces to issue a new consensus statement on recommendations surrounding the use of obesity drugs for weight loss treatment. The statement, which is published in The Lancet Diabetes & Endocrinology, is led by Dr. Laurence Dobbie of the Department of Population Health Sciences, King’s College London, with an international team of 26 authors.

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Medicare prescriptions for Wegovy jumped after approval for heart disease

Friday, July 10 – Medicare prescriptions for Wegovy increased sharply after the program started covering the anti-obesity medication to prevent heart problems, but just a fraction of beneficiaries likely eligible received the treatment, according to new research published in the American Journal of Managed Care by the USC Schaeffer Center for Health Policy & Economics.

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The Ozempic and Wegovy mistake sending thousands to poison control

Thursday, July 9 – Poison control calls involving semaglutide (Ozempic and Wegovy) soared after the drug was approved for weight management, with researchers linking the increase to accidental dosing mistakes rather than intentional misuse. Simple education about proper weekly dosing and gradual dose increases could help prevent many of these avoidable incidents.

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Closeup of blue pill in palmx

AstraZeneca’s New Oral GLP-1 Aids Weight Loss and Lowers Blood Sugar

Wednesday, July 8 – AstraZeneca’s new oral GLP-1 pill showed promising results for weight loss and blood sugar in a phase 2 trial. Guido Mieth/Getty Images

A new GLP-1 oral medication from AstraZeneca, known as elecoglipron, lowered blood sugar levels and led to 10.5% weight loss in a phase 2b clinical trial.

Experts say GLP-1 drugs in tablet form may encourage more people to take these medications to help treat type 2 diabetes and obesity.

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New weight loss pill beats oral Ozempic in major trial

Wednesday, July 8 – A new once-daily weight-loss pill called orforglipron delivered better weight loss and blood sugar improvements for people with type 2 diabetes than the leading oral semaglutide in a major clinical trial. The tablet could offer a more convenient alternative to injectable drugs like Ozempic and Wegovy because it doesn’t require refrigeration or special timing with meals. It’s also cheaper to manufacture, which could expand access globally.

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Generic Mounjaro, Zepbound May Be Coming, Rivaling Current GLP-1s

Tuesday, July 7 – Federal regulators have agreed to review a Swiss pharmaceutical company’s applications for two cheaper generic versions of Zepbound and Mounjaro. MK Photo/Alamy Stock Photo

Federal regulators have agreed to review the applications from Swiss pharmaceutical company Sandoz for two cheaper generic versions of the tirzepatide medications Zepbound and Mounjaro.

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Secret Shopper Study Warns About Online GLP-1 Sellers

Tuesday, July 7 – (MedPage Today) — Two-thirds of online GLP-1 receptor agonist sellers did not require speaking with a clinician ahead of a prescription, a secret shopper study revealed.
Out of 49 websites tested, 13 required a video visit and three required…

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Oral GLP-1 Drug May Simplify Diabetes Treatment

Tuesday, July 7 – (MedPage Today) — At the American Diabetes Association annual meeting, results from the ACHIEVE-5 trial showed that adding oral orforglipron (Foundayo) to basal insulin significantly improved glycemic control, reduced body weight, and limited…

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Wegovy weight-loss pill goes on sale on UK high street and online pharmacies

Tuesday, July 7 – Thousands of people begin receiving their first deliveries of once-a-day medication made by Novo Nordisk A once-a-day Wegovy weight-loss pill has gone on sale at high street and online pharmacies in the UK, but is not yet available on the NHS.Thousands of people began receiving their first deliveries of the pill, made by the Danish drugmaker Novo Nordisk, on Monday. It contains the same active GLP-1 ingredient as the Wegovy jab, semaglutide, and is similarly effective, according to studies. Continue reading…

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Twice-Monthly GLP-1 Shot Helps Manage Blood Sugar, Weight Loss in Trial

Saturday, July 4 – A new biweekly GLP-1 injection has been shown to significantly reduce blood sugar in a clinical trial. Image Credit: Hannes P Albert/picture alliance via Getty Images

A new GLP-1 medication demonstrated efficacy in reducing blood sugar in people with type 2 diabetes in a phase 2b clinical trial. 

Bofanglutide is a biweekly (once every 2 weeks) injection compared to once-weekly shots like Ozempic and Wegovy. 

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7 things to know about Medicare’s new GLP-1 coverage

Friday, July 3 – For decades, it’s been against the law for Medicare to pay for weight-loss medication. But that changed on July 1, with the launch of a new program called Bridge. It gives some people over 65, or who have Medicare for other reasons, access to some weight management medications if they meet certain weight and health criteria.

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GLP-1 drugs outperform SGLT-2 drugs for patients with Afib and type 2 diabetes

Thursday, July 2 – Individuals with atrial fibrillation (Afib), or irregular heart rhythm, are at increased risk of stroke, chronic kidney disease and heart failure. These risks are significantly exacerbated if a type 2 diabetes diagnosis is added to the mix, says Md Mohaimenul Islam, Ph.D., research assistant professor in the Department of Pharmacy Practice in the University at Buffalo School of Pharmacy and Pharmaceutical Sciences.

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