Oncobesity News Posts

GLP-1 drugs may protect the heart beyond weight loss, trial results suggest
With the use of GLP-1 medications on the rise, cardiologists are seeing benefits to heart health, and it might not all be related to weight loss alone. GLP-1 medications, including semaglutide, are a class of drugs that act on receptors throughout the body, influencing insulin sensitivity, appetite regulation, inflammation and metabolic health. These therapies traditionally were used to treat diabetes; however, weight loss is a well-recognized side effect, and they are now used for weight loss goals.

Kailera, Hengrui Push Oral GLP-1/GIP Pill to Phase 3 After Clearing Mid-Stage China Study
Kailera will launch a global Phase 2 study of ribupatide this year, while Hengrui will push the asset into Phase 3 in China.

New Novo Nordisk weight-loss drug more effective than Wegovy in clinical trial

Hims Pulls Cheaper Wegovy Pill After Federal Scrutiny
MONDAY, Feb. 9, 2026 — Hims & Hers says it will stop selling a low-cost copy of a new weight-loss pill made by Novo Nordisk, after federal officials raised concerns that the product may violate drug laws.
The online health company…

Novo Sues Hims & Hers Over Compounded Version of Oral Wegovy Pill
Novo Nordisk has sued Hims for allegedly violating patents protecting semaglutide, seeking potentially “hundreds of millions” in damages, John Kuckelman, the pharma’s general counsel, said. The wellness platform pulled its version of the drug just days after launching it.

Novo Nordisk sues Hims over Wegovy patent infringement, considers seeking ‘hundreds of millions’ in damages
Novo Nordisk on Monday said it is suing telehealth company Hims & Hers for allegedly infringing its patent on the weight loss medication semaglutide — not just for the pill version but also for the injectable …

STAT+: Novo Nordisk sues Hims & Hers for infringing on a key Wegovy patent
Novo Nordisk sues Hims & Hers for infringing on a key Wegovy patent.

Can Ozempic Cure Addiction?
GLP-1 drugs, which have helped some people curb drug and alcohol use, may unlock a pathway to moderation.

Hims says it will stop selling GLP-1 pill, after legal pressure from US
The telehealth company Hims & Hers said it will no longer sell a compounded version of Novo Nordisk’s Wegovy pill, just days after announcing the new product.
The move comes after Novo, which launched its …

You’ve reached your weight loss goal on GLP-1 medications. What now?
GLP-1 drugs have ushered in a new era in weight loss.

The Hims vs. Novo showdown; Pfizer’s monthly GLP-1 data; Q4 earnings roundup; and more
Welcome back to another edition of Endpoints Weekly! It’s Super Bowl weekend with the Patriots and Seahawks fighting for the championship. While our many Boston-area readers are surely excited, most of us here in New …

STAT+: HHS asks Justice Department to probe Hims & Hers over its cheaper compounded version of Wegovy
FDA will take “decisive steps” to thwart companies from mass marketing unapproved, compounded versions of GLP-1 drugs

US calls for DOJ investigation of Hims over GLP-1 drugs
The US government said it will refer telehealth and GLP-1 company Hims & Hers to the Department of Justice for investigation, following the company’s controversial launch of a compounded version of Novo …

Synergizing global clinical trials data: GLP-1 receptor agonist safety and novel clinical applications
A research team led by the Department of Medicine, under the School of Clinical Medicine, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has synergized the impacts of worldwide clinical trial data through a series of meta-analyses on GLP‑1 receptor agonists, an emerging cardiometabolic drug, offering in-depth insights into its safety profile and novel therapeutic potential in treating cardiovascular diseases.

Use of GLP-1 Drugs Under Scrutiny at Winter Olympics
(MedPage Today) — As the Winter Olympic Games get underway, the World Anti-Doping Agency (WADA) is monitoring an unexpected class of drugs: GLP-1 receptor agonists.
An advisory group that makes recommendations about WADA’s list of prohibited…

STAT+: Pharmalittle: We’re reading about TrumpRx, Hims & Hers selling compounded Wegovy, and more
President Trump on Thursday night launched TrumpRx, the website he and his aides have touted as a platform aimed at lowering drug prices

STAT+: IPOs, GLP-1s, and challenges with a gene therapy
And other biotech news brought to you by The Readout

Makary Blasts ‘Illegal Copycat Drugs’ as Hims Launches Compounded Wegovy Pill
Novo Nordisk has also spoken out strongly against Hims & Hers’ compounded Wegovy pill, with CEO Maziar Mike Doustdar telling investors the knockoff version is a waste of money.

Post-Hoc Live: Analyzing the Novo vs. Hims GLP-1 showdown
I’ve been waiting for the big showdown between drugmakers and compounders for months, and it’s finally here.
Today on Post-Hoc Live at 12 p.m. ET, we’ll be talking about telehealth company Hims & Hers’ plan …

Obesity Space Abuzz With Oral, Amylin Assets as Momentum Rides Into 2026
Biopharma’s obsession with the weight loss sector—projected to exceed $130 billion in revenue by 2035—shows no signs of slowing down as analysts gear up for a year that will test the oral market and provide key data on novel mechanisms.

FDA chief Makary takes aim at Hims’ compounded Wegovy pill plans
FDA Commissioner Marty Makary took a not-so-subtle swipe at Hims & Hers in a social media post Thursday, saying his agency would “take swift action against companies mass-marketing illegal copycat drugs.”
Without naming Hims, Makary’ …

2026 GLP-1 Super Bowl Commercials May Be Game Changers for Weight Loss Drugs
New GLP-1 ads, like telehealth provider Ro’s new campaign featuring tennis icon Serena Williams, aim to shift the conversation about weight loss drugs.
This year, the Super Bowl will feature advertising of GLP-1 drugs in new ways.
Telehealth provider Ro is using tennis star Serena Williams to help break down stigma.

Novo’s threat to sue Hims over Wegovy pill faces legal hurdle
Novo Nordisk’s threatened legal action against Hims & Hers for selling a compounded version of the pharma giant’s newly launched Wegovy pill may be far from a slam-dunk win.
Dae Lee, an attorney at Buchanan …

Challenges for a crucial sickle cell treatment and the latest outlook for GLP-1s
This week on “The Readout LOUD”: We discuss financial outlooks from Novo Nordisk and Eli Lilly, a closer look at why manufacturing problems have slowed the rollout of a crucial…

STAT+: Novo Nordisk accuses Hims & Hers of ‘illegal mass compounding’ over a cheaper version of Wegovy pill
Hims & Hers is making available a cheaper, compounded version of the Wegovy weight loss pill sold by Novo Nordisk, prompting the drugmaker to accuse the telehealth platform of “illegal…

Hims & Hers Launches Copy of Wegovy Pill, Prompting Legal Threats
(MedPage Today) — Telehealth company Hims & Hers said Thursday it will launch a cheaper, off-brand version of the weight-loss pill semaglutide (Wegovy), just weeks after drugmaker Novo Nordisk launched its highly anticipated reformulation…

Novo Nordisk vows legal action to protect Wegovy pill
Novo Nordisk said Thursday it would take legal action against a US chain offering a copycat of the new pill version of its Wegovy weight-loss drug.

Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists Use in Elderly People With Obesity-A Meta-Analysis
CONCLUSIONS: GLP-1 RA therapy seems to be safe and effective in older adults with obesity, achieving similar effects on weight loss and glycemic control as in younger individuals.

Efficacy and Safety of Oral GLP-1 RA Orforglipron on Weight and Glycemic Control According to Diabetes Status: A Systematic Review and Meta-Analysis
Excess body weight and poor metabolic control remain major contributors to cardiometabolic disease, highlighting the need for effective therapeutic options. This meta-analysis aimed to evaluate the efficacy and safety of once-daily oral orforglipron in obese adults with and without diabetes. Searches were conducted across four databases through November 2025. Five randomized controlled trials (n = 6140) were included. Orforglipron produced consistent, dose-dependent reductions in body weight,…

A personalized, evidence-based approach to obesity therapy using clinical algorithms: semaglutide or tirzepatide
On June 26, 2025, a meeting of the expert working group was held in Moscow. The discussion focused on the personalized approach of tirzepatide («Tirzetta®») and semaglutide («Velgia Eco®») in patients with excess body weight, obesity, and type 2 diabetes. Following the meeting, the objective was set to develop a consensus-based algorithm for prescribing these drugs to ensure their effective use in Russian clinical practice.

Nutritional status with tirzepatide in obesity: A post hoc analysis of the SURMOUNT-1-4 randomized clinical trials
CONCLUSIONS: TEAEs and treatment discontinuations due to macronutrient malnutrition were uncommon in the SURMOUNT-1-4 trials of tirzepatide for obesity. Lack of routinely collected vitamin and mineral levels during the trials limited assessment of the impact of tirzepatide treatment on micronutrient status. Systematic assessment of nutritional status before and during OMM treatment would enhance future trials.

Beyond lifestyle modification: the role of GLP-1 receptor agonists in treating pediatric obesity
Childhood obesity is a global health crisis with limited effective therapies beyond lifestyle modification. This review examines the growing role of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in the management of pediatric obesity. Simultaneously, this study highlights the critical considerations for clinicians in administering these medications, including long-term safety, efficacy, potential adverse effects, and overall clinical utility. To enhance the effectiveness of GLP-1 RAs in…

Variable Effects of Glucagon Like Peptide-1 Receptor Agonists on Body Composition in Older Women
CONCLUSION: Clinicians should consider recommending individualized exercise programs and dietary strategies for older patients taking GLP-1 RAs. Routine assessment of body composition may help guide interventions and optimize clinical outcomes.

GLP-1s and the Super Bowl
The Super Bowl is once again getting the GLP-1 ad treatment.
Hims & Hers is back with another combative spot that calls out the disparities in healthcare experiences between the …

Big Pharma’s most valuable up-and-coming GLP-1s
Late-stage GLP-1 candidates from Eli Lilly, Novo Nordisk and Amgen have a combined net present value of $68 billion.

Lilly Axes Three Therapies Amid Pipeline-in-a-Product Push for GLP-1
One of the assets shelved by Eli Lilly is a gene therapy for dementia, which it obtained in its $1.04-billion acquisition of Prevail Therapeutics in late 2020.

A sneak peek of pharma’s Super Bowl ads: GLP-1s, tight ends, and more
What drug ads will air during Sunday’s Super Bowl? STATus Report host Alex Hogan and reporter at large Damian Garde have a rundown of what to expect.

Semaglutide improves cardiovascular health but price reductions are needed to make it cost-effective, study finds
Semaglutide, the active ingredient in the weight-loss medications Ozempic and Wegovy, offers substantial cardiovascular benefits for selected patients without diabetes who have established heart disease, but further price reductions are needed to make the therapy good value for money, according to a new analysis from researchers at Beth Israel Deaconess Medical Center (BIDMC).

Lilly Eyes Pipeline in a Product as GLP-1s Move Into I&I
In addition to claiming revenue of $19.3 billion for the fourth quarter, Eli Lilly executives offered a glimpse into their strategy to expand their GLP-1 franchise into the immunology and inflammation space, with trials currently underway in asthma, psoriatic arthritis, Crohn’s disease and ulcerative colitis.

GLP-1 ‘Agonorexia’; Psychotic Disorders Rising in Young People; Pink Noise Pitfalls
(MedPage Today) — Clinicians are seeing more cases of “agonorexia,” when use of GLP-1 receptor agonists turns into disordered eating. (New York Post)
Colorado could become the first state to use ibogaine, a plant-based psychoactive compound…